Synthesis and Antiproliferative Activity of Novel 1,2,4Triazolo1,5-apyrimidine-7-amine Derivatives

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	Synthesis and Antiproliferative Activity of Novel 1,2,4Triazolo1,5-apyrimidine-7-amine Derivatives
其他题名	Synthesis and Antiproliferative Activity of Novel 1,2,4Triazolo1,5-apyrimidine-7-amine Derivatives
	Zhai Xin; Zhang Cunlong; He Lei; Li Qi; Wang Jiuliang; Shen Xiaoli; Gong Ping
	2009
发表期刊	CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
ISSN	1005-9040
卷号	25 期号:4 页码:474-479
摘要	A series of novel N-anilino-2-substituted-5-methyl-1,2,4triazolo1,5-apyrimidine-7-amine derivatives was prepared and evaluated for their in vitro antiproliferative activity against two cancer cell lines, Bel-7402 and HT-1080. Most of the compounds inhibited the cell proliferation at a low concentration. Seven compounds, VI(5), VI(7), VI(10), and VI(12)-VI(15). possessed marked antiproliferative activity superior to that of cisplatin. Of these seven initial hits, compound VI(10) was the most active.
其他摘要	A series of novel N-anilino-2-substituted-5-methyl-1,2,4triazolo1,5-apyrimidine-7-amine derivatives was prepared and evaluated for their in vitro antiproliferative activity against two cancer eell lines.Bel-7402 and HT-1080.Most of the compounds inhibited the cell proliferation at a low concentration.Seven compounds,VI_5,VI_7,VI_(10),and VI_(12)-VI_(15),possessed marked antiproliferative activity superior to that of cisplatin.of these seven initial hits,compound Vl_(10) was the most active.
关键词	INHIBITORS SAR 1,2,4Triazolo1,5-apyrimidines Antiproliferative activity Anticancer
收录类别	CSCD
语种	英语
CSCD记录号	CSCD:3684043
引用统计	被引频次：2[CSCD] [CSCD记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/143488
专题	中国科学院金属研究所
作者单位	中国科学院金属研究所
推荐引用方式 GB/T 7714	Zhai Xin,Zhang Cunlong,He Lei,et al. Synthesis and Antiproliferative Activity of Novel 1,2,4Triazolo1,5-apyrimidine-7-amine Derivatives[J]. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2009,25(4):474-479.
APA	Zhai Xin.,Zhang Cunlong.,He Lei.,Li Qi.,Wang Jiuliang.,...&Gong Ping.(2009).Synthesis and Antiproliferative Activity of Novel 1,2,4Triazolo1,5-apyrimidine-7-amine Derivatives.CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,25(4),474-479.
MLA	Zhai Xin,et al."Synthesis and Antiproliferative Activity of Novel 1,2,4Triazolo1,5-apyrimidine-7-amine Derivatives".CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 25.4(2009):474-479.