| Synthesis and Antiproliferative Activity of Novel 1,2,4Triazolo1,5-apyrimidine-7-amine Derivatives | |
| Alternative Title | Synthesis and Antiproliferative Activity of Novel 1,2,4Triazolo1,5-apyrimidine-7-amine Derivatives |
| Zhai Xin; Zhang Cunlong; He Lei; Li Qi; Wang Jiuliang; Shen Xiaoli; Gong Ping | |
| 2009 | |
| Source Publication | CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
 |
| ISSN | 1005-9040 |
| Volume | 25Issue:4Pages:474-479 |
| Abstract | A series of novel N-anilino-2-substituted-5-methyl-1,2,4triazolo1,5-apyrimidine-7-amine derivatives was prepared and evaluated for their in vitro antiproliferative activity against two cancer cell lines, Bel-7402 and HT-1080. Most of the compounds inhibited the cell proliferation at a low concentration. Seven compounds, VI(5), VI(7), VI(10), and VI(12)-VI(15). possessed marked antiproliferative activity superior to that of cisplatin. Of these seven initial hits, compound VI(10) was the most active. |
| Other Abstract | A series of novel N-anilino-2-substituted-5-methyl-1,2,4triazolo1,5-apyrimidine-7-amine derivatives was prepared and evaluated for their in vitro antiproliferative activity against two cancer eell lines.Bel-7402 and HT-1080.Most of the compounds inhibited the cell proliferation at a low concentration.Seven compounds,VI_5,VI_7,VI_(10),and VI_(12)-VI_(15),possessed marked antiproliferative activity superior to that of cisplatin.of these seven initial hits,compound Vl_(10) was the most active. |
| Keyword | INHIBITORS SAR 1,2,4Triazolo1,5-apyrimidines Antiproliferative activity Anticancer |
| Indexed By | CSCD |
| Language | 英语 |
| CSCD ID | CSCD:3684043 |
| Citation statistics |
Cited Times:2[CSCD]
[CSCD Record]
|
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/143488 |
| Collection | 中国科学院金属研究所 |
| Affiliation | 中国科学院金属研究所 |
| Recommended Citation GB/T 7714 | Zhai Xin,Zhang Cunlong,He Lei,et al. Synthesis and Antiproliferative Activity of Novel 1,2,4Triazolo1,5-apyrimidine-7-amine Derivatives[J]. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2009,25(4):474-479. |
| APA | Zhai Xin.,Zhang Cunlong.,He Lei.,Li Qi.,Wang Jiuliang.,...&Gong Ping.(2009).Synthesis and Antiproliferative Activity of Novel 1,2,4Triazolo1,5-apyrimidine-7-amine Derivatives.CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,25(4),474-479. |
| MLA | Zhai Xin,et al."Synthesis and Antiproliferative Activity of Novel 1,2,4Triazolo1,5-apyrimidine-7-amine Derivatives".CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 25.4(2009):474-479. |
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