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Synthesis and Antiproliferative Activity of Novel 1,2,4Triazolo1,5-apyrimidine-7-amine Derivatives
Alternative TitleSynthesis and Antiproliferative Activity of Novel 1,2,4Triazolo1,5-apyrimidine-7-amine Derivatives
Zhai Xin; Zhang Cunlong; He Lei; Li Qi; Wang Jiuliang; Shen Xiaoli; Gong Ping
2009
Source PublicationCHEMICAL RESEARCH IN CHINESE UNIVERSITIES
ISSN1005-9040
Volume25Issue:4Pages:474-479
AbstractA series of novel N-anilino-2-substituted-5-methyl-1,2,4triazolo1,5-apyrimidine-7-amine derivatives was prepared and evaluated for their in vitro antiproliferative activity against two cancer cell lines, Bel-7402 and HT-1080. Most of the compounds inhibited the cell proliferation at a low concentration. Seven compounds, VI(5), VI(7), VI(10), and VI(12)-VI(15). possessed marked antiproliferative activity superior to that of cisplatin. Of these seven initial hits, compound VI(10) was the most active.
Other AbstractA series of novel N-anilino-2-substituted-5-methyl-1,2,4triazolo1,5-apyrimidine-7-amine derivatives was prepared and evaluated for their in vitro antiproliferative activity against two cancer eell lines.Bel-7402 and HT-1080.Most of the compounds inhibited the cell proliferation at a low concentration.Seven compounds,VI_5,VI_7,VI_(10),and VI_(12)-VI_(15),possessed marked antiproliferative activity superior to that of cisplatin.of these seven initial hits,compound Vl_(10) was the most active.
KeywordINHIBITORS SAR 1,2,4Triazolo1,5-apyrimidines Antiproliferative activity Anticancer
Indexed ByCSCD
Language英语
CSCD IDCSCD:3684043
Citation statistics
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/143488
Collection中国科学院金属研究所
Affiliation中国科学院金属研究所
Recommended Citation
GB/T 7714
Zhai Xin,Zhang Cunlong,He Lei,et al. Synthesis and Antiproliferative Activity of Novel 1,2,4Triazolo1,5-apyrimidine-7-amine Derivatives[J]. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2009,25(4):474-479.
APA Zhai Xin.,Zhang Cunlong.,He Lei.,Li Qi.,Wang Jiuliang.,...&Gong Ping.(2009).Synthesis and Antiproliferative Activity of Novel 1,2,4Triazolo1,5-apyrimidine-7-amine Derivatives.CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,25(4),474-479.
MLA Zhai Xin,et al."Synthesis and Antiproliferative Activity of Novel 1,2,4Triazolo1,5-apyrimidine-7-amine Derivatives".CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 25.4(2009):474-479.
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