Expression of CD133, PAX2, ESA, and GPR30 in invasive ductal breast carcinomas

IMR OpenIR

	Expression of CD133, PAX2, ESA, and GPR30 in invasive ductal breast carcinomas
其他题名	Expression of CD133, PAX2, ESA, and GPR30 in invasive ductal breast carcinomas
	Liu Qun; Li Jiguang; Zheng Xinyu; Jin Feng; Dong Huiting
	2009
发表期刊	CHINESE MEDICAL JOURNAL
ISSN	0366-6999
卷号	122 期号:22 页码:2763-2769
摘要	Background Biomarkers in breast neoplasms provide invaluable information regarding prognosis and help determining the optimal treatment. We have examined the possible correlation between cancer stem cell (CSC)-like markers (CD133, paired box gene 2 protein (PAX2), epithelial specific antigen (ESA)), and a new membrane estrogen receptor (G-protein coupled receptor 30 (GPR30)) in invasive ductal breast carcinomas with known clinicopathological parameters, tumor recurrence, and expression of some known biomarkers.
其他摘要	Background Biomarkers in breast neoplasms provide invaluable information regarding prognosis and help determining the optimal treatment. We have examined the possible correlation between cancer stem cell (CSC)-Iike markers (CD133,paired box gene 2 protein (PAX2), epithelial specific antigen (ESA)), and a new membrane estrogen receptor (G-protein coupled receptor 30 (GPR30)) in invasive ductal breast carcinomas with known clinicopathological parameters, tumor recurrence, and expression of some known biomarkers.Methods In 74 invasive ductal breast carcinomas, we investigated the protein expression of these molecular markers by immunohistochemistry, and their associations with known clinicopathological parameters, tumor recurrence, and expression of some known biomarkers. We studied the interrelationship between the expressions of these proteins.Results CD133, a putative CSC marker, was positively related to tumor size, tumor stage, and lymph node metastasis.PAX2 was negatively correlated with tumor recurrence. ESA, one of the breast CSC markers, was an indicator of tumor recurrence. GPR30 was associated with hormone receptors. Despite the correlation between GPR30 and the nuclear estrogen receptor, the expression was dependent. Positive staining of GPR30 in tumors displayed a significant association with high C-erbB2 expression and a tendency for tumor recurrence. A positive relationship between GPR30 and CD133 existed.Conclusion Detecting the expression of CD133, PAX2, ESA, and GPR30 in invasive ductal breast carcinomas may be of help in more accurately predicting the aggressive properties of breast cancer and determining the optimal treatment.
关键词	GROWTH-FACTOR RECEPTOR CELL MARKER CD133 ESTROGEN-RECEPTOR CANCER CELLS STEM IDENTIFICATION ASSOCIATION SURVIVAL TUMOR CD44(+)/CD24(-) breast neoplasms immunohistochemistry tumor markers retrospective study
收录类别	CSCD
语种	英语
资助项目	[National "863 Program" of China]
CSCD记录号	CSCD:3733133
引用统计
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/143650
专题	中国科学院金属研究所
作者单位	中国科学院金属研究所
推荐引用方式 GB/T 7714	Liu Qun,Li Jiguang,Zheng Xinyu,et al. Expression of CD133, PAX2, ESA, and GPR30 in invasive ductal breast carcinomas[J]. CHINESE MEDICAL JOURNAL,2009,122(22):2763-2769.
APA	Liu Qun,Li Jiguang,Zheng Xinyu,Jin Feng,&Dong Huiting.(2009).Expression of CD133, PAX2, ESA, and GPR30 in invasive ductal breast carcinomas.CHINESE MEDICAL JOURNAL,122(22),2763-2769.
MLA	Liu Qun,et al."Expression of CD133, PAX2, ESA, and GPR30 in invasive ductal breast carcinomas".CHINESE MEDICAL JOURNAL 122.22(2009):2763-2769.