The wetting behavior and interracial interaction of Zr41 25Ti13.75Ni10Cu12. 5Be22. 5 molten on W were studied by the sessile drop method in high vacuum. Tungsten fiber reinforced Zr41.25Ti13.75Ni10Cu12.5Be22.5 bulk metallic glass matrix composite was fabricated by infiltration process. The results show that there is a good wettability in Zr41.25Ti13 .75Ni10Cu12.5Be22. 5 molten/W wetting system between 1053 K and 1173 K. Increase of wetting temperature resulted in the decrease of equilibrium contact angle and the increase of spreading rate and solution of W. It had little effects on the equilibrium contact angle and the equilibrium wetting time when increasing above 1173 K. Good wettability and rapid spread rate provided a wide operating space for fabricating tungsten fiber reinforced Zr41.25Ti13 75Ni10Cu12.5Be22. 5 bulk metallic glass matrix composite.