A case of polymyositis with ophthalmoplegia - Laboratory examinations

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	A case of polymyositis with ophthalmoplegia - Laboratory examinations
其他题名	A case of polymyositis with ophthalmoplegia: Laboratory examinations
	Han Shunchang 1; Pu Chuanqiang 2; Huang Xusheng 2; Lang Senyang 2; Wu Weiping 2
	2008
发表期刊	NEURAL REGENERATION RESEARCH
ISSN	1673-5374
卷号	3 期号:3 页码:345-348
摘要	OBJECTIVE: Polymyositis (PM) mainly involves proximal limb and trunk muscles. Ocular muscles are not affected, except in rare cases, with both PM and myasthenia gravis (MG). Thus, the results of laboratory examinations in such a patient deserve to be reported.
其他摘要	OBJECTIVE: Polymyositis (PM) mainly involves proximal limb and trunk muscles. Ocular muscles are not affected, except in rare cases with both PM and myasthenia gravis (MG). Thus, the results of laboratory examinations in such a patient deserve to be reported.METHODS: To analyze the clinical, imaging and pathology datas on a 65-year-old woman patient with PM with complex symptoms, who presented mainly ophthalmoplegia. The patient consented to all examinations and the hospital Ethics Committee approved the study. The laboratory examinations included creatine kinase (CK), ENA, tumor marker, function of thyroid, cranial MRI, and electromyogram (EMG). Biopsy of the left quadriceps femoris was performed, frozen specimens were stained with hematoxylin and eosin, ATPase, NADH tetrazolium reductase, periodic acid Schiff, oil red O, modified Gomory trichrome and MHC-I, to investigate the pathology of muscle fibers RESULTS: Laboratory results showed: CK, 108.32μkat/L; antinuclear antibody: (+); ENA, (-); tumor marker, (-); normal thyroid function, MRI showed no abnormal signals in brain and extraocular muscles. Electromyography of the bilateral deltoid, biceps brachii, musculus quadriceps fexoris, anterior tibialis showed fibrillation potentials, positive potentials and short-duration, small-amplitude polyphasic potentials on voluntary movements with a full interference pattern on mild exertion. Repetitive stimulation did not result in any increment or decrement in these potentials. A muscle biopsy of the left quadriceps femoris showed many small round muscle fibers without peripheral bundle distribution and apparent myofiber degeneration, necrosis and phagocytosis. There were several focal lymphocyte infiltrations. MHC-I immunohistochemical staining was positive in most fibers revealing inflammatory infiltration of normal fibers with MHC-I expression. CONCLUSION: This patient showed increased CK, typical triad of myopathy in EMG, and apparent degeneration and necrosis in biopsy of quadriceps femoris. Therefore, the diagnosis of PM and involvement of extraocular muscles were definite.
关键词	EXTERNAL OPHTHALMOPLEGIA MYOSITIS DERMATOMYOSITIS INVOLVEMENT PATIENT polymyositis ophthalmoplegia electromyogram
收录类别	CSCD
语种	英语
CSCD记录号	CSCD:3299725
引用统计
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/144314
专题	中国科学院金属研究所
作者单位	1.中国科学院金属研究所 2.Gen Hosp Chinese PLA, Department Neurol, Beijing 100853, Peoples R China Department Neurol
推荐引用方式 GB/T 7714	Han Shunchang,Pu Chuanqiang,Huang Xusheng,et al. A case of polymyositis with ophthalmoplegia - Laboratory examinations[J]. NEURAL REGENERATION RESEARCH,2008,3(3):345-348.
APA	Han Shunchang,Pu Chuanqiang,Huang Xusheng,Lang Senyang,&Wu Weiping.(2008).A case of polymyositis with ophthalmoplegia - Laboratory examinations.NEURAL REGENERATION RESEARCH,3(3),345-348.
MLA	Han Shunchang,et al."A case of polymyositis with ophthalmoplegia - Laboratory examinations".NEURAL REGENERATION RESEARCH 3.3(2008):345-348.