Expression of cyclinD1 in a rat model of oxygen-induced retinopathy

IMR OpenIR

	Expression of cyclinD1 in a rat model of oxygen-induced retinopathy
其他题名	Expression of cyclinD1 in a rat model of oxygen-induced retinopathy
	Li You; Zhang Yuqiang; Shi Shaoyang; Chen Xiaolong
	2011
发表期刊	NEURAL REGENERATION RESEARCH
ISSN	1673-5374
卷号	6 期号:21 页码:1651-1655
摘要	This study sought to elucidate the correlation between cyclinD1 expression and the emergence of neovascularization in oxygen-induced retinopathy (OIR). OIR was induced in Sprague-Dawley 7-day-old neonatal rats exposed to hyperoxia (75% O(2)) for 5 days, and then returned to room air. Adenosine diphosphatase staining showed that the neovascularization started to emerge at rat age of day 14, and reached a peak at day 17, then gradually decreased and resolved by day 26. Immunohistochemical and immunofluorescence staining revealed that cyclinD1 protein expression was seen in the OIR rats at the age of day 12, then gradually increased and returned to normal levels by day 26. These experimental findings demonstrated that the temporal pattern of cyclinD1 protein expression is consistent with the emergence of retinal neovascularization.
其他摘要	This study sought to elucidate the correlation between cyclinD1 expression and the emergence of neovascularization in oxygen-induced retinopathy(OIR).OIR was induced in Sprague-Dawley 7-day-old neonatal rats exposed to hyperoxia(75%O2)for 5 days,and then returned to room air.Adenosine diphosphatase staining showed that the neovascularization started to emerge at rat age of day 14,and reached a peak at day 17,then gradually decreased and resolved by day 26.Immunohistochemical and immunofluorescence staining revealed that cyclinD1 protein expression was seen in the OIR rats at the age of day 12,then gradually increased and returned to normal levels by day 26.These experimental findings demonstrated that the temporal pattern of cyclinD1 protein expression is consistent with the emergence of retinal neovascularization.
关键词	VASCULAR LEAKAGE GROWTH-FACTOR PREMATURITY RETINA NEOVASCULARIZATION CELLS IGF-1 VEGF ROP oxygen-induced retinopathy cyclinD1 neovascularization rat
收录类别	CSCD
语种	英语
CSCD记录号	CSCD:4310653
引用统计
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/144345
专题	中国科学院金属研究所
作者单位	中国科学院金属研究所
推荐引用方式 GB/T 7714	Li You,Zhang Yuqiang,Shi Shaoyang,et al. Expression of cyclinD1 in a rat model of oxygen-induced retinopathy[J]. NEURAL REGENERATION RESEARCH,2011,6(21):1651-1655.
APA	Li You,Zhang Yuqiang,Shi Shaoyang,&Chen Xiaolong.(2011).Expression of cyclinD1 in a rat model of oxygen-induced retinopathy.NEURAL REGENERATION RESEARCH,6(21),1651-1655.
MLA	Li You,et al."Expression of cyclinD1 in a rat model of oxygen-induced retinopathy".NEURAL REGENERATION RESEARCH 6.21(2011):1651-1655.