Neuronal differentiation of adipose-derived stem cells and their transplantation for cerebral ischemia

IMR OpenIR

	Neuronal differentiation of adipose-derived stem cells and their transplantation for cerebral ischemia
其他题名	Neuronal differentiation of adipose-derived stem cells and their transplantation for cerebral ischemia
	Tian Guoping; Zhou Jin; Wang Jinge; Xu Bing; Li Li; Zhu Feng; Han Jian; Li Jianping; Zhang Siyang; Luo Xiaoguang
	2012
发表期刊	NEURAL REGENERATION RESEARCH
ISSN	1673-5374
卷号	7 期号:25 页码:1992-1999
摘要	OBJECTIVE: To review published data on the biological characteristics, differentiation and applications of adipose-derived stem cells in ischemic diseases.
其他摘要	OBJECTIVE: To review published data on the biological characteristics, differentiation and applications of adipose-derived stem cells in ischemic diseases. DATA RETRIEVAL: A computer-based online search of reports published from January 2005 to June 2012 related to the development of adipose-derived stem cells and their transplantation for treatment of cerebral ischemia was performed in Web of Science using the key words “adipose-derived stem cells”, “neural-like cells”, “transplantation”, “stroke”, and “cerebral ischemia”. SELECTION CRITERIA: The documents associated with the development of adipose-derived stem cells and their transplantation for treatment of cerebral ischemia were selected, and those published in the last 3–5 years or in authoritative journals were preferred in the same field. Totally 89 articles were obtained in the initial retrieval, of which 53 were chosen based on the inclusion criteria. MAIN OUTCOME MEASURES: Biological characteristics and induced differentiation of adipose-derived stem cells and cell transplantation for disease treatment as well as the underlying mechanism of clinical application. RESULTS: The advantages of adipose-derived stem cells include their ease of procurement, wide availability, rapid expansion, low tumorigenesis, low immunogenicity, and absence of ethical constraints. Preclinical experiments have demonstrated that transplanted adipose-derived stem cells can improve neurological functions, reduce small regions of cerebral infarction, promote angiogenesis, and express neuron-specific markers. The improvement of neurological functions was demonstrated in experiments using different methods and time courses of adipose-derived stem cell transplantation, but the mechanisms remain unclear. CONCLUSION: Further research into the treatment of ischemic disease by adipose-derived stem cell transplantation is needed to determine their mechanism of action.
关键词	MESENCHYMAL STROMAL CELLS CONDITIONED MEDIUM IN-VITRO INTRACEREBRAL HEMORRHAGE LINEAGE CELLS SELF-RENEWAL TISSUE THERAPY ANGIOGENESIS SECRETION adipose-derived stem cells adipose stem cells differentiation adipose tissue neural-like cells transplantation stroke cerebral ischemia cerebrovascular disease stem cell therapy
收录类别	CSCD
语种	英语
资助项目	[Research Foundation of Shenyang Scientific Committee]
CSCD记录号	CSCD:4648170
引用统计	被引频次：2[CSCD] [CSCD记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/144673
专题	中国科学院金属研究所
作者单位	中国科学院金属研究所
推荐引用方式 GB/T 7714	Tian Guoping,Zhou Jin,Wang Jinge,et al. Neuronal differentiation of adipose-derived stem cells and their transplantation for cerebral ischemia[J]. NEURAL REGENERATION RESEARCH,2012,7(25):1992-1999.
APA	Tian Guoping.,Zhou Jin.,Wang Jinge.,Xu Bing.,Li Li.,...&Luo Xiaoguang.(2012).Neuronal differentiation of adipose-derived stem cells and their transplantation for cerebral ischemia.NEURAL REGENERATION RESEARCH,7(25),1992-1999.
MLA	Tian Guoping,et al."Neuronal differentiation of adipose-derived stem cells and their transplantation for cerebral ischemia".NEURAL REGENERATION RESEARCH 7.25(2012):1992-1999.