Study on synthesis, crystal structure and anticancer activity of complex cis-Pd(bipy-ethyl)Cl-2

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	Study on synthesis, crystal structure and anticancer activity of complex cis-Pd(bipy-ethyl)Cl-2
其他题名	Study on Synthesis, Crystal Structure and Anticancer Activity of Complex cis-Pd(bipy-ethyl)Cl_2
	Sun YaGuang; Gu XiaoFu; Wu Qiong; Gao EnJun; Yin HongXi; Ren LiXiang
	2008
发表期刊	CHINESE JOURNAL OF INORGANIC CHEMISTRY
ISSN	1001-4861
卷号	24 期号:4 页码:515-519
摘要	The complex cis-Pd(bipy-ethyl)Cl-2 (bipy-ethyl=2,2'-bipyridine-3-ethyl formate) was synthesized under hydrothermal conditions. X-ray crystal structure analysis was carried out to determine the crystal structure of the title complex. The crystal of the title complex belongs to orthorhombic system with space group Pbca. The Pd2+ ions was coordinated by two nitrogen atoms of bipy-ethyl and two terminal chlorine ions, rendering a quadrangle geometry. There are abundant C-H center dot center dot center dot Cl interaction, C-H center dot center dot center dot O interaction and Pd-Aromatic interaction between adjacent complexes. The inhibitory activity of complex with cancer cell of Hela, Hep-G2 and KB were mensurated by vitro activity methods. The result shows that although inhibitory activity of complex is not as good as cis-DDP, the complex still has strong ability to kill cancer cell.
关键词	PLATINATED COMPLEXES CYTOTOXIC ACTIVITY HYDROGEN-BONDS DNA THIOSEMICARBAZONE FRAMEWORKS PATTERNS BINDING LIGAND CELLS coordinate complex Pd(II) crystal structure anticancer activity
收录类别	CSCD
语种	英语
CSCD记录号	CSCD:3263901
引用统计
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/144863
专题	中国科学院金属研究所
作者单位	中国科学院金属研究所
推荐引用方式 GB/T 7714	Sun YaGuang,Gu XiaoFu,Wu Qiong,et al. Study on synthesis, crystal structure and anticancer activity of complex cis-Pd(bipy-ethyl)Cl-2[J]. CHINESE JOURNAL OF INORGANIC CHEMISTRY,2008,24(4):515-519.
APA	Sun YaGuang,Gu XiaoFu,Wu Qiong,Gao EnJun,Yin HongXi,&Ren LiXiang.(2008).Study on synthesis, crystal structure and anticancer activity of complex cis-Pd(bipy-ethyl)Cl-2.CHINESE JOURNAL OF INORGANIC CHEMISTRY,24(4),515-519.
MLA	Sun YaGuang,et al."Study on synthesis, crystal structure and anticancer activity of complex cis-Pd(bipy-ethyl)Cl-2".CHINESE JOURNAL OF INORGANIC CHEMISTRY 24.4(2008):515-519.