| Study on synthesis, crystal structure and anticancer activity of complex cis-Pd(bipy-ethyl)Cl-2 | |
| Alternative Title | Study on Synthesis, Crystal Structure and Anticancer Activity of Complex cis-Pd(bipy-ethyl)Cl_2 |
| Sun YaGuang; Gu XiaoFu; Wu Qiong; Gao EnJun; Yin HongXi; Ren LiXiang | |
| 2008 | |
| Source Publication | CHINESE JOURNAL OF INORGANIC CHEMISTRY
 |
| ISSN | 1001-4861 |
| Volume | 24Issue:4Pages:515-519 |
| Abstract | The complex cis-Pd(bipy-ethyl)Cl-2 (bipy-ethyl=2,2'-bipyridine-3-ethyl formate) was synthesized under hydrothermal conditions. X-ray crystal structure analysis was carried out to determine the crystal structure of the title complex. The crystal of the title complex belongs to orthorhombic system with space group Pbca. The Pd2+ ions was coordinated by two nitrogen atoms of bipy-ethyl and two terminal chlorine ions, rendering a quadrangle geometry. There are abundant C-H center dot center dot center dot Cl interaction, C-H center dot center dot center dot O interaction and Pd-Aromatic interaction between adjacent complexes. The inhibitory activity of complex with cancer cell of Hela, Hep-G2 and KB were mensurated by vitro activity methods. The result shows that although inhibitory activity of complex is not as good as cis-DDP, the complex still has strong ability to kill cancer cell. |
| Keyword | PLATINATED COMPLEXES CYTOTOXIC ACTIVITY HYDROGEN-BONDS DNA THIOSEMICARBAZONE FRAMEWORKS PATTERNS BINDING LIGAND CELLS coordinate complex Pd(II) crystal structure anticancer activity |
| Indexed By | CSCD |
| Language | 英语 |
| CSCD ID | CSCD:3263901 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/144863 |
| Collection | 中国科学院金属研究所 |
| Affiliation | 中国科学院金属研究所 |
| Recommended Citation GB/T 7714 | Sun YaGuang,Gu XiaoFu,Wu Qiong,et al. Study on synthesis, crystal structure and anticancer activity of complex cis-Pd(bipy-ethyl)Cl-2[J]. CHINESE JOURNAL OF INORGANIC CHEMISTRY,2008,24(4):515-519. |
| APA | Sun YaGuang,Gu XiaoFu,Wu Qiong,Gao EnJun,Yin HongXi,&Ren LiXiang.(2008).Study on synthesis, crystal structure and anticancer activity of complex cis-Pd(bipy-ethyl)Cl-2.CHINESE JOURNAL OF INORGANIC CHEMISTRY,24(4),515-519. |
| MLA | Sun YaGuang,et al."Study on synthesis, crystal structure and anticancer activity of complex cis-Pd(bipy-ethyl)Cl-2".CHINESE JOURNAL OF INORGANIC CHEMISTRY 24.4(2008):515-519. |
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