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Evaluating Authentic Quality of Longdanxiegn Pill by Systematic Quantified Fingerprint Method
Alternative TitleEvaluating Authentic Quality of Longdanxiegn Pill by Systematic Quantified Fingerprint Method
Sun GuoXiang; Zhang JingXian
2009
Source PublicationCHINESE JOURNAL OF ANALYTICAL CHEMISTRY
ISSN0253-3820
Volume37Issue:8Pages:1183-1187
AbstractUsing systematic quantified fingerprint method to assess the HPLC fingerprint of Longdanxiegan pill (LDXGP), in which the chromatographic fingerprints (CFPs) were determined by reversed-phase HPLC. The 1.2 batches of LDXGP were identified with hierarchical clustering analysis by using micro qualitative similarity as the variable. According to the results of classification, the referential fingerprint (RFP) was synthesized from 10 batches of LDXGP. Taking the RFP for the qualified model, the whole 1.2 batches of LDXGP were evaluated by the systematic quantified fingerprint method. The CFPs containing 60 co-possessing peaks were obtained when choosing gentiopicroside peak as the referential peak. Among the 12 batches of LDXGP, 8 batches were completely qualified, the content of I batch was obviously higher while I batch was lower, and the chemical constituents quantity and distributed proportion in 2 batches were not qualified. Systematic quantified fingerprint method closely combined the macro qualitative analysis with macro quantitative analysis, it can effectively assess the authentic quality of Chinese traditional medicine.
KeywordPERFORMANCE LIQUID-CHROMATOGRAPHY Systematic quantified fingerprint method Longdanxiegen pill high performance liquid chromatography fingerprint macro qualitative similarity macro quantitative similarity chromatographic fingerprint relative informative index
Indexed ByCSCD
Language英语
CSCD IDCSCD:3663192
Citation statistics
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/145342
Collection中国科学院金属研究所
Affiliation中国科学院金属研究所
Recommended Citation
GB/T 7714
Sun GuoXiang,Zhang JingXian. Evaluating Authentic Quality of Longdanxiegn Pill by Systematic Quantified Fingerprint Method[J]. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,2009,37(8):1183-1187.
APA Sun GuoXiang,&Zhang JingXian.(2009).Evaluating Authentic Quality of Longdanxiegn Pill by Systematic Quantified Fingerprint Method.CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,37(8),1183-1187.
MLA Sun GuoXiang,et al."Evaluating Authentic Quality of Longdanxiegn Pill by Systematic Quantified Fingerprint Method".CHINESE JOURNAL OF ANALYTICAL CHEMISTRY 37.8(2009):1183-1187.
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