Serum pepsinogen and osteopontin for gastric cancer screening

IMR OpenIR

	Serum pepsinogen and osteopontin for gastric cancer screening
其他题名	Serum Pepsinogen and Osteopontin for Gastric Cancer Screening
	Gong YueHua; Sun LiPing; Yuan Yuan
	2007
发表期刊	CHINESE JOURNAL OF CANCER RESEARCH
ISSN	1000-9604
卷号	19 期号:3 页码:153-158
摘要	Objective: To investigate the value of combined assay of serum pepsinogen (PG) and osteopontin (OPN) levels for gastric cancer screening. Methods: Fasting serum pepsinogen I, II and OPN concentration were measured by ELISA in 570 subjects. The cut off points for PG and OPN were determined using ROC. Results: Using serum PGI concentration = 34 ng/ml or >= 30.44 ng/ml (based on ROC) for gastric cancer screening had superior specificity, positive and negative predictive values compared with PG or OPN screening only. The sensitive and specificity of combining serum PG and OPN assay were both more than 70% compared with PG or OPN screening alone. Conclusion: Combining serum PG and OPN assay for gastric cancer screening is superior to PG or OPN level only. This may be a new method for gastric cancer mass screening.
其他摘要	Objective: To investigate the value of combined assay of serum pepsinogen (PG) and osteopontin (OPN) levels for gastric cancer screening. Methods: Fasting serum pepsinogen Ⅰ, Ⅱ and OPN concentration were measured by ELISA in 570 subjects. The cut off points for PG and OPN were determined using ROC. Results: Using serum PGI concentration ≤80 ng/ml, Ⅰ:Ⅱ ration ≤5.0 and OPN concentration ≥34 ng/ml or ≥30.44 ng/ml (based on ROC)for gastric cancer screening had superior specificity, positive and negative predictive values compared with PG or OPN screening only. The sensitive and specificity of combining serum PG and OPN assay were both more than 70% compared with PG or OPN screening alone. Conclusion: Combining serum PG and OPN assay for gastric cancer screening is superior to PG or OPN level only. This may be a new method for gastric cancer mass screening.
关键词	HELICOBACTER-PYLORI METASTASIS EXPRESSION PROSTATE PROTEIN ANTIBODIES JAPANESE MARKERS PLASMA BREAST gastric cancer cancer screening serology tumor marker
收录类别	CSCD
语种	英语
CSCD记录号	CSCD:2927947
引用统计
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/145726
专题	中国科学院金属研究所
作者单位	中国科学院金属研究所
推荐引用方式 GB/T 7714	Gong YueHua,Sun LiPing,Yuan Yuan. Serum pepsinogen and osteopontin for gastric cancer screening[J]. CHINESE JOURNAL OF CANCER RESEARCH,2007,19(3):153-158.
APA	Gong YueHua,Sun LiPing,&Yuan Yuan.(2007).Serum pepsinogen and osteopontin for gastric cancer screening.CHINESE JOURNAL OF CANCER RESEARCH,19(3),153-158.
MLA	Gong YueHua,et al."Serum pepsinogen and osteopontin for gastric cancer screening".CHINESE JOURNAL OF CANCER RESEARCH 19.3(2007):153-158.