| The Protective Role of Procyanidins and Lycopene Against Mercuric Chloride Renal Damage in Rats | |
| Alternative Title | The Protective Role of Procyanidins and Lycopene Against Mercuric Chloride Renal Damage in Rats |
| Yang HaiBo; Xu ZhaoFa; Liu Wei; Deng Yu; Xu Bin | |
| 2011 | |
| Source Publication | BIOMEDICAL AND ENVIRONMENTAL SCIENCES
 |
| ISSN | 0895-3988 |
| Volume | 24Issue:5Pages:550-559 |
| Abstract | Objective This study aims to investigate the protection of procyanidins and lycopene from the renal damage induced by mercuric chloride. |
| Other Abstract | Objective This study aims to investigate the protection of procyanidins and lycopene from the renal damage induced by mercuric chloride. Methods Rats were treated with either procyanidins or lycopene 2h before HgCI2 subcutaneously injection, once daily treatment for 2 successive days. Results In comparison with HgCI2 group, markers of renal function such as blood urea nitrogen in serum and urinary protein were decreased to(18.45±11.63) mmol/L and(15.93±9.36) mmol/L, (4.54±0.78) g/(g·Cr) and(4.40±1.12) g/(g·Cr). N-acetyl-beta-D-glucosaminidase, lactate dehydrogenase, alkaline phosphatase in urine were depressed to(125.49±11.68) U/(g·Cr), (103.73±21.79) U/(g·Cr), (101.99±12.28) U/(g·Cr), and(113.19±23.74) U/(g·Cr), (71.14±21.80) U/(g·Cr), (73.64±21.51) U/(g·Cr) in procyanidins and lycopene groups. Indicators of oxidative stress, for example, Glutathion was reduced to(45.58±9.89) μmol/(g·pro) and(45.33±5.90) μmol/(g·pro), and antioxidant enzymes such as superoxide dismutase, glutathione-peroxidase were enhanced to(43.07±10.97) U/(mg·pro) and(39.94±6.04) U/(mg·pro), (83.85±18.48) U/(mg·pro), and(85.62±12.68) U/(mg·pro). Malondialdehyde was lowered to(0.95±0.12) (μmol/g·pro) and(1.03±0.12) μmol/(g·pro) in procyanidins and lycopene groups. ROS generation was decreased by 27.63% and 16.40% and apoptosis was also decreased in procyanidins and lycopene groups respectively. Pathological changes were much better as well. Conclusion Procyanidins and Lycopene play some protective role against mercury kidney damage. |
| Keyword | SEED PROANTHOCYANIDIN EXTRACT 90-DAY ORAL TOXICITY OXIDATIVE STRESS ASSAY MICE NEPHROTOXICITY CAROTENOIDS PREVENTION SELENIUM TISSUES Mercuric chloride Procyanidins Lycopene Renal damage Protection |
| Indexed By | CSCD |
| Language | 英语 |
| CSCD ID | CSCD:4347850 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/145791 |
| Collection | 中国科学院金属研究所 |
| Affiliation | 中国科学院金属研究所 |
| Recommended Citation GB/T 7714 | Yang HaiBo,Xu ZhaoFa,Liu Wei,et al. The Protective Role of Procyanidins and Lycopene Against Mercuric Chloride Renal Damage in Rats[J]. BIOMEDICAL AND ENVIRONMENTAL SCIENCES,2011,24(5):550-559. |
| APA | Yang HaiBo,Xu ZhaoFa,Liu Wei,Deng Yu,&Xu Bin.(2011).The Protective Role of Procyanidins and Lycopene Against Mercuric Chloride Renal Damage in Rats.BIOMEDICAL AND ENVIRONMENTAL SCIENCES,24(5),550-559. |
| MLA | Yang HaiBo,et al."The Protective Role of Procyanidins and Lycopene Against Mercuric Chloride Renal Damage in Rats".BIOMEDICAL AND ENVIRONMENTAL SCIENCES 24.5(2011):550-559. |
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