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Early diagnosis of epithelial ovarian cancer with cDNA microarry
Alternative TitleEarly diagnosis of epithelial ovarian cancer with cDNA microarry
Chen Ying1; Zheng Huachuan2; Zhao Yujie1; Xin Yan1
2008
Source PublicationCHINESE JOURNAL OF CANCER RESEARCH
ISSN1000-9604
Volume20Issue:2Pages:110-114
AbstractObjective: To investigate the roles of tumor suppressor genes-PTEN, nm23H(1), VEGF(165), Tiam1, MMP-2, Timp2, HE4 and S100A4 in tumorigenesis and progression of epithelial ovarian cancer(EOC) and develop a novel method for the early diagnosis of EOC. Methods: We observed the different expression profiles of those genes in normal ovary(n=5) and ovarian cancer tissue (n=20) by cDNA microarray. Results: In EOC, PTEN, Timp2 and nm23H1 genes were down-regulated (CY-3/CY-50.5), compared with the normal ovary, whereas Tiam1, VEGF165, MMP- 2, HE4 and S100A4 genes were up-regulated (CY-3/CY-5>2.0). Among them, HE4 gene was remarkably elevated (CY-3/CY-5>5.0). Their expression was correlated with clinicopathological staging of EOC(P<0.01). Conclusion: Those genes are closely linked to the pathogenesis and progression of EOC. cDNA microarray is an effective technique to screen molecular biological markers and predict the metastastic potential of EOC in early diagnosis.
Other AbstractObjective:To investigate the roles of tumor suppressor genes-PTEN,nm23H_1,VEGF_(165),Tiam1,MMP-2,Timp2,HE4 and S100A4 in tumorigenesis and progression of epithelial ovarian cancer(EOC)and develop a novel method for the early diagnosis of EOC.Methods:We observed the different expression profiles of those genes in normal ovary(n=5)and ovarian cancer tissue(n=20)by cDNA microarray.Results:In EOC,PTEN,Timp2 and nm23H_1 genes were down-regulated (CY-3/CY-5 2.0).Among them,HE4 gene was remarkably elevated(CY-3/CY-5>5.0).Their expression was correlated with clinicopathological staging of EOC(P<0.01).Conclusion:Those genes are closely linked to the pathogenesis and progression of EOC.cDNA microarray is an effective technique to screen molecular biological markers and predict the metastastic potential of EOC in early diagnosis.
KeywordTUMOR PROGRESSION CELLS genes cDNA microarray early diagnosis
Indexed ByCSCD
Language英语
CSCD IDCSCD:3299651
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Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/145846
Collection中国科学院金属研究所
Affiliation1.中国科学院金属研究所
2.中国科学院地质与地球物理研究所
Recommended Citation
GB/T 7714
Chen Ying,Zheng Huachuan,Zhao Yujie,et al. Early diagnosis of epithelial ovarian cancer with cDNA microarry[J]. CHINESE JOURNAL OF CANCER RESEARCH,2008,20(2):110-114.
APA Chen Ying,Zheng Huachuan,Zhao Yujie,&Xin Yan.(2008).Early diagnosis of epithelial ovarian cancer with cDNA microarry.CHINESE JOURNAL OF CANCER RESEARCH,20(2),110-114.
MLA Chen Ying,et al."Early diagnosis of epithelial ovarian cancer with cDNA microarry".CHINESE JOURNAL OF CANCER RESEARCH 20.2(2008):110-114.
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