| Early diagnosis of epithelial ovarian cancer with cDNA microarry | |
| Alternative Title | Early diagnosis of epithelial ovarian cancer with cDNA microarry |
| Chen Ying1; Zheng Huachuan2; Zhao Yujie1; Xin Yan1 | |
| 2008 | |
| Source Publication | CHINESE JOURNAL OF CANCER RESEARCH
 |
| ISSN | 1000-9604 |
| Volume | 20Issue:2Pages:110-114 |
| Abstract | Objective: To investigate the roles of tumor suppressor genes-PTEN, nm23H(1), VEGF(165), Tiam1, MMP-2, Timp2, HE4 and S100A4 in tumorigenesis and progression of epithelial ovarian cancer(EOC) and develop a novel method for the early diagnosis of EOC. Methods: We observed the different expression profiles of those genes in normal ovary(n=5) and ovarian cancer tissue (n=20) by cDNA microarray. Results: In EOC, PTEN, Timp2 and nm23H1 genes were down-regulated (CY-3/CY-50.5), compared with the normal ovary, whereas Tiam1, VEGF165, MMP- 2, HE4 and S100A4 genes were up-regulated (CY-3/CY-5>2.0). Among them, HE4 gene was remarkably elevated (CY-3/CY-5>5.0). Their expression was correlated with clinicopathological staging of EOC(P<0.01). Conclusion: Those genes are closely linked to the pathogenesis and progression of EOC. cDNA microarray is an effective technique to screen molecular biological markers and predict the metastastic potential of EOC in early diagnosis. |
| Other Abstract | Objective:To investigate the roles of tumor suppressor genes-PTEN,nm23H_1,VEGF_(165),Tiam1,MMP-2,Timp2,HE4 and S100A4 in tumorigenesis and progression of epithelial ovarian cancer(EOC)and develop a novel method for the early diagnosis of EOC.Methods:We observed the different expression profiles of those genes in normal ovary(n=5)and ovarian cancer tissue(n=20)by cDNA microarray.Results:In EOC,PTEN,Timp2 and nm23H_1 genes were down-regulated (CY-3/CY-5 2.0).Among them,HE4 gene was remarkably elevated(CY-3/CY-5>5.0).Their expression was correlated with clinicopathological staging of EOC(P<0.01).Conclusion:Those genes are closely linked to the pathogenesis and progression of EOC.cDNA microarray is an effective technique to screen molecular biological markers and predict the metastastic potential of EOC in early diagnosis. |
| Keyword | TUMOR PROGRESSION CELLS genes cDNA microarray early diagnosis |
| Indexed By | CSCD |
| Language | 英语 |
| CSCD ID | CSCD:3299651 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/145846 |
| Collection | 中国科学院金属研究所 |
| Affiliation | 1.中国科学院金属研究所 2.中国科学院地质与地球物理研究所 |
| Recommended Citation GB/T 7714 | Chen Ying,Zheng Huachuan,Zhao Yujie,et al. Early diagnosis of epithelial ovarian cancer with cDNA microarry[J]. CHINESE JOURNAL OF CANCER RESEARCH,2008,20(2):110-114. |
| APA | Chen Ying,Zheng Huachuan,Zhao Yujie,&Xin Yan.(2008).Early diagnosis of epithelial ovarian cancer with cDNA microarry.CHINESE JOURNAL OF CANCER RESEARCH,20(2),110-114. |
| MLA | Chen Ying,et al."Early diagnosis of epithelial ovarian cancer with cDNA microarry".CHINESE JOURNAL OF CANCER RESEARCH 20.2(2008):110-114. |
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