Polymorphisms of UGT1A7 and XRCC1 are associated with an increased risk of hepatocellular carcinoma in Northeast China

IMR OpenIR

	Polymorphisms of UGT1A7 and XRCC1 are associated with an increased risk of hepatocellular carcinoma in Northeast China
其他题名	Polymorphisms of UGT1A7 and XRCC1 are Associated with an Increased Risk of Hepatocellular Carcinoma in Northeast China
	Jia Zhifang; Su Hongying; Li Xuelian; Xu Xin; Yin Zhihua; Guan Peng; Zhou Baosen
	2010
发表期刊	CHINESE JOURNAL OF CANCER RESEARCH
ISSN	1000-9604
卷号	22 期号:4 页码:260-266
摘要	Hepatocellular carcinoma (HCC) is a complex disease which associates with both environmental and genetic factors. The purpose of this study was to investigate whether the genetic polymorphisms of UDP-glucuronosyltransferase (UGT1A7), an important phase II biotransformation enzyme, and X-ray repair cross-complementing group 1(XRCC1), a pivotal DNA-repair gene, were related to the risk of HCC in Northeast China.
其他摘要	Objective:Hepatocellular carcinoma(HCC)is a complex disease which associates with both environmental and genetic factors.The purpose of this study was to investigate whether the genetic polymorphisms of UDP-glucuronosyltransferase(UGT1A7),an important phase II biotransformation enzyme,and X-ray repair crosscomplementing group 1(XRCC1),a pivotal DNA-repair gene,were related to the risk of HCC in Northeast China. Methods:One hundred and thirty six HCC patients and one hundred and thirty six frequency-matched controls were included in this hospital-based case-control study.Genotypes of UGT1A7 and XRCC1 were determined using allele-specific polymerase chain reaction(AS-PCR)and PCR-restriction fragment length polymorphism(RFLP),and for which the odds ratio(OR)with 95%confidence interval(95%CI)were calculated. Results:The proportion of UGT1A7 low enzymatic allele(~2 or~ 3)was higher in HCC patients than those in controls.The UGT1A7~* 1/~* 2 and~3/~ 3 genotypes were associated with higher HCC risk(OR=2.09,95%CI:1.10-3.97; OR=5.67,95%CI:1.76-18.30,respectively).The XRCC1 codon 399 Arg/Gln genotype could also elevate HCC risk (OR=2.16,95%CI 1.29-3.61).In addition to polymorphisms of UGT1A7 and XRCC1,multivariate logistic regression analysis demonstrated that other significant independent factors associated with HCC were HBV infection(OR=68.07, 95%CI:28.03-165.26),HCV infection(OR=30.97,95%CI:8.06-118.94)and family history of HCC(OR=10.62, 95%CI:2.22-50.77). Conclusion:The study shows that the polymorphisms of UGT1A7 and XRCC1 are associated with HCC risk. Determination of the polymorphisms of UGT1A7 and XRCC1 may provide an important clue to preventive measure against HCC
关键词	UDP-GLUCURONOSYLTRANSFERASE 1A7 COLORECTAL-CANCER RISK GENETIC POLYMORPHISMS DNA-REPAIR CIGARETTE-SMOKING LUNG-CANCER ENZYMES POPULATION METABOLISM EXPOSURE Hepatocellular carcinoma (UDP)-glucuronosyltransferase 1A7(UGT1A7) X-ray repair cross-complementing group 1(XRCC1) Risk factors Genetic polymorphism
收录类别	CSCD
语种	英语
资助项目	[Department of Education of Liaoning Province, China]
CSCD记录号	CSCD:4075595
引用统计
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/146053
专题	中国科学院金属研究所
作者单位	中国科学院金属研究所
推荐引用方式 GB/T 7714	Jia Zhifang,Su Hongying,Li Xuelian,et al. Polymorphisms of UGT1A7 and XRCC1 are associated with an increased risk of hepatocellular carcinoma in Northeast China[J]. CHINESE JOURNAL OF CANCER RESEARCH,2010,22(4):260-266.
APA	Jia Zhifang.,Su Hongying.,Li Xuelian.,Xu Xin.,Yin Zhihua.,...&Zhou Baosen.(2010).Polymorphisms of UGT1A7 and XRCC1 are associated with an increased risk of hepatocellular carcinoma in Northeast China.CHINESE JOURNAL OF CANCER RESEARCH,22(4),260-266.
MLA	Jia Zhifang,et al."Polymorphisms of UGT1A7 and XRCC1 are associated with an increased risk of hepatocellular carcinoma in Northeast China".CHINESE JOURNAL OF CANCER RESEARCH 22.4(2010):260-266.