Deep-Tissue Photothermal Therapy Using Laser Illumination at NIR-IIa Window

IMR OpenIR

	Deep-Tissue Photothermal Therapy Using Laser Illumination at NIR-IIa Window
	Wu Xunzhi 1; Suo Yongkuan 1; Shi Hui 1; Liu Ruiqi 1; Wu Fengxia 1; Wang Tingzhong 1; Ma Lina 2; Liu Hongguang 1; Cheng Zhen 3
	2020
发表期刊	Nano-Micro Letters
ISSN	2311-6706
卷号	12 期号:1 页码:1-13
摘要	Abstract Photothermal therapy (PTT) using near-infrared (NIR) light for tumor treatment has triggered extensive attentions because of its advantages of noninvasion and convenience. The current research on PTT usually uses lasers in the first NIR window (NIR-I; 700–900nm) as irradiation source. However, the second NIR window (NIR-II; 1000–1700nm) especially NIR-IIa window (1300–1400nm) is considered much more promising in diagnosis and treatment as its superiority in penetration depth and maximum permissible exposure over NIR-I window. Hereby, we propose the use of laser excitation at 1275nm, which is approved by Food and Drug Administration for physical therapy, as an attractive technique for PTT to balance of tissue absorption and scattering with water absorption. Specifically, CuS-PEG nanoparticles with similar absorption values at 1275 and 808nm, a conventional NIR-I window for PTT, were synthesized as PTT agents and a comparison platform, to explore the potential of 1275 and 808nm lasers for PTT, especially in deep-tissue settings. The results showed that 1275nm laser was practicable in PTT. It exhibited much more desirable outcomes in cell ablation in vitro and deep-tissue antitumor capabilities in vivo compared to that of 808nm laser. NIR-IIa laser illumination is superior to NIR-I laser for deep-tissue PTT, and shows high potential to improve the PTT outcome.
关键词	Photothermal therapy Deep-tissue NIR-IIa 1275nm laser Molecular imaging Technology T
收录类别	CSCD
语种	英语
资助项目	[Natural Science Foundation of China] ; [Clinical Capability Construction Project for Liaoning Provincial Hospitals] ; [China postdoctoral science foundation]
CSCD记录号	CSCD:6728351
引用统计	被引频次：2[CSCD] [CSCD记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/146099
专题	中国科学院金属研究所
作者单位	1.中国科学院金属研究所 2.中国科学院 3.史丹佛大学
推荐引用方式 GB/T 7714	Wu Xunzhi,Suo Yongkuan,Shi Hui,et al. Deep-Tissue Photothermal Therapy Using Laser Illumination at NIR-IIa Window[J]. Nano-Micro Letters,2020,12(1):1-13.
APA	Wu Xunzhi.,Suo Yongkuan.,Shi Hui.,Liu Ruiqi.,Wu Fengxia.,...&Cheng Zhen.(2020).Deep-Tissue Photothermal Therapy Using Laser Illumination at NIR-IIa Window.Nano-Micro Letters,12(1),1-13.
MLA	Wu Xunzhi,et al."Deep-Tissue Photothermal Therapy Using Laser Illumination at NIR-IIa Window".Nano-Micro Letters 12.1(2020):1-13.