| Deep-Tissue Photothermal Therapy Using Laser Illumination at NIR-IIa Window | |
| Wu Xunzhi1; Suo Yongkuan1; Shi Hui1; Liu Ruiqi1; Wu Fengxia1; Wang Tingzhong1; Ma Lina2; Liu Hongguang1; Cheng Zhen3 | |
| 2020 | |
| Source Publication | Nano-Micro Letters
 |
| ISSN | 2311-6706 |
| Volume | 12Issue:1Pages:1-13 |
| Abstract | Abstract Photothermal therapy (PTT) using near-infrared (NIR) light for tumor treatment has triggered extensive attentions because of its advantages of noninvasion and convenience. The current research on PTT usually uses lasers in the first NIR window (NIR-I; 700–900nm) as irradiation source. However, the second NIR window (NIR-II; 1000–1700nm) especially NIR-IIa window (1300–1400nm) is considered much more promising in diagnosis and treatment as its superiority in penetration depth and maximum permissible exposure over NIR-I window. Hereby, we propose the use of laser excitation at 1275nm, which is approved by Food and Drug Administration for physical therapy, as an attractive technique for PTT to balance of tissue absorption and scattering with water absorption. Specifically, CuS-PEG nanoparticles with similar absorption values at 1275 and 808nm, a conventional NIR-I window for PTT, were synthesized as PTT agents and a comparison platform, to explore the potential of 1275 and 808nm lasers for PTT, especially in deep-tissue settings. The results showed that 1275nm laser was practicable in PTT. It exhibited much more desirable outcomes in cell ablation in vitro and deep-tissue antitumor capabilities in vivo compared to that of 808nm laser. NIR-IIa laser illumination is superior to NIR-I laser for deep-tissue PTT, and shows high potential to improve the PTT outcome. |
| Keyword | Photothermal therapy Deep-tissue NIR-IIa 1275nm laser Molecular imaging Technology T |
| Indexed By | CSCD |
| Language | 英语 |
| Funding Project | [Natural Science Foundation of China] ; [Clinical Capability Construction Project for Liaoning Provincial Hospitals] ; [China postdoctoral science foundation] |
| CSCD ID | CSCD:6728351 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/146099 |
| Collection | 中国科学院金属研究所 |
| Affiliation | 1.中国科学院金属研究所 2.中国科学院 3.史丹佛大学 |
| Recommended Citation GB/T 7714 | Wu Xunzhi,Suo Yongkuan,Shi Hui,et al. Deep-Tissue Photothermal Therapy Using Laser Illumination at NIR-IIa Window[J]. Nano-Micro Letters,2020,12(1):1-13. |
| APA | Wu Xunzhi.,Suo Yongkuan.,Shi Hui.,Liu Ruiqi.,Wu Fengxia.,...&Cheng Zhen.(2020).Deep-Tissue Photothermal Therapy Using Laser Illumination at NIR-IIa Window.Nano-Micro Letters,12(1),1-13. |
| MLA | Wu Xunzhi,et al."Deep-Tissue Photothermal Therapy Using Laser Illumination at NIR-IIa Window".Nano-Micro Letters 12.1(2020):1-13. |
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