Deep-Tissue Photothermal Therapy Using Laser Illumination at NIR-IIa Window
Wu Xunzhi1; Suo Yongkuan1; Shi Hui1; Liu Ruiqi1; Wu Fengxia1; Wang Tingzhong1; Ma Lina2; Liu Hongguang1; Cheng Zhen3
Source PublicationNano-Micro Letters
AbstractAbstract Photothermal therapy (PTT) using near-infrared (NIR) light for tumor treatment has triggered extensive attentions because of its advantages of noninvasion and convenience. The current research on PTT usually uses lasers in the first NIR window (NIR-I; 700–900nm) as irradiation source. However, the second NIR window (NIR-II; 1000–1700nm) especially NIR-IIa window (1300–1400nm) is considered much more promising in diagnosis and treatment as its superiority in penetration depth and maximum permissible exposure over NIR-I window. Hereby, we propose the use of laser excitation at 1275nm, which is approved by Food and Drug Administration for physical therapy, as an attractive technique for PTT to balance of tissue absorption and scattering with water absorption. Specifically, CuS-PEG nanoparticles with similar absorption values at 1275 and 808nm, a conventional NIR-I window for PTT, were synthesized as PTT agents and a comparison platform, to explore the potential of 1275 and 808nm lasers for PTT, especially in deep-tissue settings. The results showed that 1275nm laser was practicable in PTT. It exhibited much more desirable outcomes in cell ablation in vitro and deep-tissue antitumor capabilities in vivo compared to that of 808nm laser. NIR-IIa laser illumination is superior to NIR-I laser for deep-tissue PTT, and shows high potential to improve the PTT outcome.
KeywordPhotothermal therapy Deep-tissue NIR-IIa 1275nm laser Molecular imaging Technology T
Indexed ByCSCD
Funding Project[Natural Science Foundation of China] ; [Clinical Capability Construction Project for Liaoning Provincial Hospitals] ; [China postdoctoral science foundation]
Citation statistics
Document Type期刊论文
Recommended Citation
GB/T 7714
Wu Xunzhi,Suo Yongkuan,Shi Hui,et al. Deep-Tissue Photothermal Therapy Using Laser Illumination at NIR-IIa Window[J]. Nano-Micro Letters,2020,12(1):1-13.
APA Wu Xunzhi.,Suo Yongkuan.,Shi Hui.,Liu Ruiqi.,Wu Fengxia.,...&Cheng Zhen.(2020).Deep-Tissue Photothermal Therapy Using Laser Illumination at NIR-IIa Window.Nano-Micro Letters,12(1),1-13.
MLA Wu Xunzhi,et al."Deep-Tissue Photothermal Therapy Using Laser Illumination at NIR-IIa Window".Nano-Micro Letters 12.1(2020):1-13.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Wu Xunzhi]'s Articles
[Suo Yongkuan]'s Articles
[Shi Hui]'s Articles
Baidu academic
Similar articles in Baidu academic
[Wu Xunzhi]'s Articles
[Suo Yongkuan]'s Articles
[Shi Hui]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Wu Xunzhi]'s Articles
[Suo Yongkuan]'s Articles
[Shi Hui]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.