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Synthesis and Antitumor Activities of Novel 4-Morpholinothieno3,2-dpyrimidine Derivatives
Alternative TitleSynthesis and Antitumor Activities of Novel 4-Morpholinothieno3,2-dpyrimidine Derivatives
Song Kaizhen; Ma Junjie; Wang Xiao; Gong Ping; Zhao Yanfang
2014
Source PublicationCHEMICAL RESEARCH IN CHINESE UNIVERSITIES
ISSN1005-9040
Volume30Issue:1Pages:75-81
AbstractA series of novel 2-hydrazinyl-4-morpholinothieno3,2-dpyrimidine derivatives was designed and synthesized. All of them were screened for their cytotoxic activities against large cell lung cancer(H460), colon cancer (HT-29) and adenocarcinomic lung cancer(A549) cell lines in vitro. The pharmacological results indicate that most of the target compounds show moderate to significant activities. Especially compound 17 exhibits the most potent antitumor activities against H460, HT-29 and A549 cell lines with IC50 values of 0.57, 0.45 and 1.45 mu mol/L, respectively.
Other AbstractA series of novel 2-hydrazinyl-4-morpholinothieno3,2-dpyrimidine derivatives was designed and synthesized. All of them were screened for their cytotoxic activities against large cell lung cancer(H460), colon cancer (HT-29) and adenocarcinomic lung cancer(A549) cell lines in vitro. The pharmacological results indicate that most of the target compounds show moderate to significant activities. Especially compound 17 exhibits the most potent antitumor activities against H460, HT-29 and A549 cell lines with IC_(50) values of 0.57, 0.45 and 1.45 μmol/L, respectively.
KeywordCANCER POTENT INHIBITOR KINASE 2-Hydrazinyl-4-morpholinothieno3,2-dpyrimidine Antitumor activity Cytotoxic activity
Indexed ByCSCD
Language英语
Funding Project[Ministry of Education of China] ; [Program for Liaoning Innovative Research Team in University, China]
CSCD IDCSCD:5051263
Citation statistics
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/146108
Collection中国科学院金属研究所
Affiliation中国科学院金属研究所
Recommended Citation
GB/T 7714
Song Kaizhen,Ma Junjie,Wang Xiao,et al. Synthesis and Antitumor Activities of Novel 4-Morpholinothieno3,2-dpyrimidine Derivatives[J]. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2014,30(1):75-81.
APA Song Kaizhen,Ma Junjie,Wang Xiao,Gong Ping,&Zhao Yanfang.(2014).Synthesis and Antitumor Activities of Novel 4-Morpholinothieno3,2-dpyrimidine Derivatives.CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,30(1),75-81.
MLA Song Kaizhen,et al."Synthesis and Antitumor Activities of Novel 4-Morpholinothieno3,2-dpyrimidine Derivatives".CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 30.1(2014):75-81.
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