| Synthesis and Antitumor Activities of Novel 4-Morpholinothieno3,2-dpyrimidine Derivatives | |
| Alternative Title | Synthesis and Antitumor Activities of Novel 4-Morpholinothieno3,2-dpyrimidine Derivatives |
| Song Kaizhen; Ma Junjie; Wang Xiao; Gong Ping; Zhao Yanfang | |
| 2014 | |
| Source Publication | CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
 |
| ISSN | 1005-9040 |
| Volume | 30Issue:1Pages:75-81 |
| Abstract | A series of novel 2-hydrazinyl-4-morpholinothieno3,2-dpyrimidine derivatives was designed and synthesized. All of them were screened for their cytotoxic activities against large cell lung cancer(H460), colon cancer (HT-29) and adenocarcinomic lung cancer(A549) cell lines in vitro. The pharmacological results indicate that most of the target compounds show moderate to significant activities. Especially compound 17 exhibits the most potent antitumor activities against H460, HT-29 and A549 cell lines with IC50 values of 0.57, 0.45 and 1.45 mu mol/L, respectively. |
| Other Abstract | A series of novel 2-hydrazinyl-4-morpholinothieno3,2-dpyrimidine derivatives was designed and synthesized. All of them were screened for their cytotoxic activities against large cell lung cancer(H460), colon cancer (HT-29) and adenocarcinomic lung cancer(A549) cell lines in vitro. The pharmacological results indicate that most of the target compounds show moderate to significant activities. Especially compound 17 exhibits the most potent antitumor activities against H460, HT-29 and A549 cell lines with IC_(50) values of 0.57, 0.45 and 1.45 μmol/L, respectively. |
| Keyword | CANCER POTENT INHIBITOR KINASE 2-Hydrazinyl-4-morpholinothieno3,2-dpyrimidine Antitumor activity Cytotoxic activity |
| Indexed By | CSCD |
| Language | 英语 |
| Funding Project | [Ministry of Education of China] ; [Program for Liaoning Innovative Research Team in University, China] |
| CSCD ID | CSCD:5051263 |
| Citation statistics |
Cited Times:2[CSCD]
[CSCD Record]
|
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/146108 |
| Collection | 中国科学院金属研究所 |
| Affiliation | 中国科学院金属研究所 |
| Recommended Citation GB/T 7714 | Song Kaizhen,Ma Junjie,Wang Xiao,et al. Synthesis and Antitumor Activities of Novel 4-Morpholinothieno3,2-dpyrimidine Derivatives[J]. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2014,30(1):75-81. |
| APA | Song Kaizhen,Ma Junjie,Wang Xiao,Gong Ping,&Zhao Yanfang.(2014).Synthesis and Antitumor Activities of Novel 4-Morpholinothieno3,2-dpyrimidine Derivatives.CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,30(1),75-81. |
| MLA | Song Kaizhen,et al."Synthesis and Antitumor Activities of Novel 4-Morpholinothieno3,2-dpyrimidine Derivatives".CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 30.1(2014):75-81. |
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