Expression of obesity hormone leptin in human colorectal cancer

IMR OpenIR

	Expression of obesity hormone leptin in human colorectal cancer
其他题名	Expression of Obesity Hormone Leptin in Human Colorectal Cancer
	Cong Jinchun; Dai Xianwei; Shen Mingyang; Wang Junjiang; Chen Chunsheng; Zhang Hong; Qiao Lei
	2009
发表期刊	CHINESE JOURNAL OF CANCER RESEARCH
ISSN	1000-9604
卷号	21 期号:2 页码:142-146
摘要	The obesity hormone, leptin, has been found to participate in the development and proliferation of normal and malignant tissues. The aim of this study was to evaluate the role of leptin in human colorectal cancer.
其他摘要	Objective: The obesity hormone, leptin, has been found to participate in the development and proliferation of normal and malignant tissues. The aim of this study was to evaluate the role of leptin in human colorectal cancer.Methods: Serum leptin levels were measured via ABC-ELLSA in 30 colorectal cancers and 24 normal controls. Leptin concentration in colorectal cancer was analyzed in terms of selected clinicopathological features and some oncogenes.Results: The mean concentration of leptin was significantly higher for colorectal cancers(3.54±1.46 ng/ml) than normal controls(2.27±0.99 ng/ml), no gender difference was observed in this study. Leptin expression in poorly differentiated tumors was obviously lower than those in moderately and well differentiated tumors. There were no statistically significant correlations between leptin and the serum CEA and CA199 in colorectal cancers (P＞0.05), and between leptin and the expressions of K-RAS, P53, APC, DCC genes in tumor tissues (P＞0.05).Conclusion: Leptin is overexpressed in human colorectal cancer, which is related to the differentiation degrees of the tumor. There is no correlation between leptin expression and chages of oncogenes in colorectal cancers.
关键词	BREAST-CANCER COLON-CANCER SERUM LEPTIN RISK GROWTH MICE PROLIFERATION AZOXYMETHANE PROMOTER LESIONS Colorectal cancer Leptin
收录类别	CSCD
语种	英语
CSCD记录号	CSCD:3525461
引用统计
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/146161
专题	中国科学院金属研究所
作者单位	中国科学院金属研究所
推荐引用方式 GB/T 7714	Cong Jinchun,Dai Xianwei,Shen Mingyang,et al. Expression of obesity hormone leptin in human colorectal cancer[J]. CHINESE JOURNAL OF CANCER RESEARCH,2009,21(2):142-146.
APA	Cong Jinchun.,Dai Xianwei.,Shen Mingyang.,Wang Junjiang.,Chen Chunsheng.,...&Qiao Lei.(2009).Expression of obesity hormone leptin in human colorectal cancer.CHINESE JOURNAL OF CANCER RESEARCH,21(2),142-146.
MLA	Cong Jinchun,et al."Expression of obesity hormone leptin in human colorectal cancer".CHINESE JOURNAL OF CANCER RESEARCH 21.2(2009):142-146.