Sphincter of Oddi hypomotility and its relationship with duodenal-biliary reflux, plasma motilin and serum gastrin

IMR OpenIR

	Sphincter of Oddi hypomotility and its relationship with duodenal-biliary reflux, plasma motilin and serum gastrin
其他题名	Sphincter of Oddi hypomotility and its relationship with duodenal-biliary reflux, plasma motilin and serum gastrin
	Zhang ZhenHai 1; Wu ShuoDong 2; Wang Bing 3; Su Yang 2; Jin JunZhe 2; Kong Jing 2; Wang HaoLin 2
	2008
发表期刊	WORLD JOURNAL OF GASTROENTEROLOGY
ISSN	1007-9327
卷号	14 期号:25 页码:4077-4081
摘要	AIM: To detect whether patients with a T tube after cholecystectomy and choledochotomy have duodenal-biliary reflux by measuring the radioactivity of Tc99m-labeled diethylene triamine penta-acetic acid (DTPA) in the bile and whether the patients with duodenal-biliary reflux have sphincter of Oddi hypomotility, by measuring the level of plasma and serum gastrin of the patients. Finally to if there is close relationship among sphincter of Oddi hypornotility, duodenal-biliary reflux and gastrointestinal peptides.
其他摘要	AIM: To detect whether patients with a T tube after cholecystectomy and choledochotomy have duodenalbiliary reflux by measuring the radioactivity of Tc99m-labeled diethylene triamine penta-acetic acid (DTPA) in the bile and whether the patients with duodenal-biliary reflux have sphincter of Oddi hypomotility, by measuring the level of plasma and serum gastrin of the patients. Finally to if there is close relationship among sphincter of Oddi hypomotility, duodenal-biliary reflux and gastrointestinal peptides.METHODS: Forty-five patients with a T tube after cholecystectomy and choledochotomy were divided into reflux group and control group. The level of plasma and serum gastrin of the patients and of 12 healthy volunteers were measured by radioimmunoassay. Thirty-four were selected randomly to undergo choledochoscope manometry. Sphincter of Oddi basal pressure (SOBP), amplitude (SOCA), frequency of contractions (SOF), duration of contractions (SOD), duodenal pressure (DP) and common bile duct pressure (CBDP) were scored and analyzed.RESULTS: Sixteen (35.6%) patients were detected to have duodenal-biliary reflux. SOBP, SOCA and CBDP in the reflux group were much lower than the control group (t=5.254, 3.438 and 3.527, P＜0.001). SOD of the reflux group was shorter than the control group (t=2.049, P＜0.05). The level of serum gastrin and plasma motilin of the reflux group was much lower than the control group (t=-2.230 and -2.235, P＜0.05). There was positive correlation between the level of plasma motilin and SOBP and between the level of serum gastrin and SOBP and CBDP.CONCLUSION: About 35.9% of the patients with a T tube after cholecystectomy and choledochotomy have duodenal-biliary reflux. Most of them have sphincter of Oddi hypomotility and the decreased level of plasma motilin and serum gastrin. The disorder of gastrointestinal hormone secretion may result in sphincter of Oddi dysfunction. There is a close relationship between sphincter of Oddi hypomotility and duodenal-biliary reflux.
关键词	BILE-DUCT STONES GASTROINTESTINAL HORMONES ENDOSCOPIC SPHINCTEROTOMY MANOMETRY POSSUM FLOW sphincter of Oddi Tc99m-labeled diethylene triamine penta-acetic acid pressure motilin gastrin
收录类别	CSCD
语种	英语
CSCD记录号	CSCD:3317685
引用统计
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/146185
专题	中国科学院金属研究所
作者单位	1.Shandong Prov Hosp, Department Hepatobiliary Surg, Jinan 250021, Shandong, Peoples R China 2.中国科学院金属研究所 3.Shandong Prov Hosp, Department Ophthalmol, Jinan 250021, Shandong, Peoples R China
推荐引用方式 GB/T 7714	Zhang ZhenHai,Wu ShuoDong,Wang Bing,et al. Sphincter of Oddi hypomotility and its relationship with duodenal-biliary reflux, plasma motilin and serum gastrin[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2008,14(25):4077-4081.
APA	Zhang ZhenHai.,Wu ShuoDong.,Wang Bing.,Su Yang.,Jin JunZhe.,...&Wang HaoLin.(2008).Sphincter of Oddi hypomotility and its relationship with duodenal-biliary reflux, plasma motilin and serum gastrin.WORLD JOURNAL OF GASTROENTEROLOGY,14(25),4077-4081.
MLA	Zhang ZhenHai,et al."Sphincter of Oddi hypomotility and its relationship with duodenal-biliary reflux, plasma motilin and serum gastrin".WORLD JOURNAL OF GASTROENTEROLOGY 14.25(2008):4077-4081.