Two new ursane-type nortriterpenes from Lonicera macranthoides and their iNOS-inhibitory activities

IMR OpenIR

	Two new ursane-type nortriterpenes from Lonicera macranthoides and their iNOS-inhibitory activities
	Mei YuDan 1; Zhang Nan 3; Zhang WeiYang 4; Tang JinShan 1; Zhou Hua 4; Yu Yang 1; Yao XinSheng 1
	2019
发表期刊	CHINESE JOURNAL OF NATURAL MEDICINES
ISSN	2095-6975
卷号	17 期号:1 页码:27-32
摘要	The flower buds of Lonicera macranthoides (Shan Yin-Hua), represent an important traditional Chinese medicine and food ingredient. A phytochemical investigation of the 70% EtOH extract of the flower buds of L. macranthoides resulted in the isolation of 12 triterpenoids (1-12), including two new ursane-type nortriterpenes, 2 alpha, 24-dihydroxy-23-nor-ursolic acid (1) and 2 alpha, 4 alpha-dihydroxy-23-nor-ursolic acid (2). Their structures were established by multiple spectroscopic methods and comparison with literature data. All isolated compounds were evaluated for their anti-inflammatory effects in LPS-activated RAW264.7 cells. Compounds 1 and 2 exhibited inhibitory effects on iNOS at the concentration of 30 mu mol.L-1.
关键词	TRITERPENOID SAPONINS GLYCOSIDES BUDS STEMS Lonicerae Flos Lonicera macranthoides Ursane-type nortriterpenes Anti-inflammation iNOS
收录类别	CSCD
语种	英语
资助项目	[National Natural Science Foundation of China] ; [Science and Technology Planning Project of Guangdong Province]
CSCD记录号	CSCD:6416308
引用统计
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/146391
专题	中国科学院金属研究所
作者单位	1.中国科学院广州地球化学研究所 2.暨南大学 3.中国科学院金属研究所 4.Macau University Sci & Technol, Fac Chinese Med, Macau 999078, Peoples R China Fac Chinese Med 5.Macau University Sci & Technol, State Key Lab Qual Res Chinese Med, Macau 999078, Peoples R China State Key Lab Qual Res Chinese Med
推荐引用方式 GB/T 7714	Mei YuDan,Zhang Nan,Zhang WeiYang,et al. Two new ursane-type nortriterpenes from Lonicera macranthoides and their iNOS-inhibitory activities[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2019,17(1):27-32.
APA	Mei YuDan.,Zhang Nan.,Zhang WeiYang.,Tang JinShan.,Zhou Hua.,...&Yao XinSheng.(2019).Two new ursane-type nortriterpenes from Lonicera macranthoides and their iNOS-inhibitory activities.CHINESE JOURNAL OF NATURAL MEDICINES,17(1),27-32.
MLA	Mei YuDan,et al."Two new ursane-type nortriterpenes from Lonicera macranthoides and their iNOS-inhibitory activities".CHINESE JOURNAL OF NATURAL MEDICINES 17.1(2019):27-32.