Aim: To investigate the influence of dosage forms on the pharmacokinetics of daidzein and its main metabolite daidzein-7-O-glucuronide in Wistar rats.
其他摘要
Aim： To investigate the influence of dosage forms on the pharmacokinetics of daidzein and its main metabolite daidzein-7-O-glucuronide in Wistar rats. Methods： After administration of two typical dosage forms （daidzein solution and suspension）, the concentrations of daidzein and daidzein-7-O-glucuronide were determined by an LC-MS-MS method. The pharmacokinetic parameters were calculated and analyzed statistically using the Student＇s t-test. Results： Absorption of daidzein after administration of daidzein solution （tmax=0.46 h） was more rapid than that of the suspension （tmax=5.00 h）. The peak plasma concentrations of daidzein after administration of daidzein solution and suspension were 601.1 μg/L and 127.3 μg/L, respectively, and those of daidzein-7-O-glucuronide were 3000 μg/L and 192.6 μg/L, respectively. The absolute bioavailabilities of free daidzein in rats after administration of daidzein solution and suspension were 12.8% and 6.1%, respectively, which were calculated to be 47.0% and 12.2%, respectively, in the form of total daidzein （free plus conjugated daidzein）. Conclusion： Absorption of daidzein solution was better than absorption of suspension （P〈0.05）.
Qiu F,Chen XY,Song B,et al. Influence of dosage forms on pharmacokinetics of daidzein and its main metabolite daidzein-7-O-glucuronide in rats[J]. ACTA PHARMACOLOGICA SINICA,2005,26(9):1145-1152.
APA
Qiu F,Chen XY,Song B,Zhong DF,&Liu CX.(2005).Influence of dosage forms on pharmacokinetics of daidzein and its main metabolite daidzein-7-O-glucuronide in rats.ACTA PHARMACOLOGICA SINICA,26(9),1145-1152.
MLA
Qiu F,et al."Influence of dosage forms on pharmacokinetics of daidzein and its main metabolite daidzein-7-O-glucuronide in rats".ACTA PHARMACOLOGICA SINICA 26.9(2005):1145-1152.
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