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Influence of dosage forms on pharmacokinetics of daidzein and its main metabolite daidzein-7-O-glucuronide in rats
Alternative TitleInfluence of dosage forms on pharmacokinetics of daidzein and its main metabolite daidzein-7-O-glucuronide in rats
Qiu F; Chen XY; Song B; Zhong DF; Liu CX
2005
Source PublicationACTA PHARMACOLOGICA SINICA
ISSN1671-4083
Volume26Issue:9Pages:1145-1152
AbstractAim: To investigate the influence of dosage forms on the pharmacokinetics of daidzein and its main metabolite daidzein-7-O-glucuronide in Wistar rats.
Other AbstractAim: To investigate the influence of dosage forms on the pharmacokinetics of daidzein and its main metabolite daidzein-7-O-glucuronide in Wistar rats. Methods: After administration of two typical dosage forms (daidzein solution and suspension), the concentrations of daidzein and daidzein-7-O-glucuronide were determined by an LC-MS-MS method. The pharmacokinetic parameters were calculated and analyzed statistically using the Student's t-test. Results: Absorption of daidzein after administration of daidzein solution (tmax=0.46 h) was more rapid than that of the suspension (tmax=5.00 h). The peak plasma concentrations of daidzein after administration of daidzein solution and suspension were 601.1 μg/L and 127.3 μg/L, respectively, and those of daidzein-7-O-glucuronide were 3000 μg/L and 192.6 μg/L, respectively. The absolute bioavailabilities of free daidzein in rats after administration of daidzein solution and suspension were 12.8% and 6.1%, respectively, which were calculated to be 47.0% and 12.2%, respectively, in the form of total daidzein (free plus conjugated daidzein). Conclusion: Absorption of daidzein solution was better than absorption of suspension (P〈0.05).
KeywordPURIFIED SOY ISOFLAVONES CLINICAL CHARACTERISTICS LIQUID-CHROMATOGRAPHY PREMENOPAUSAL WOMEN PLASMA MEN GENISTEIN URINE daidzein daidzein-7-O-glucuronide influence dosage forms pharmacokinetics rats
Indexed ByCSCD
Language英语
CSCD IDCSCD:2208518
Citation statistics
Cited Times:5[CSCD]   [CSCD Record]
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/146538
Collection中国科学院金属研究所
Affiliation中国科学院金属研究所
Recommended Citation
GB/T 7714
Qiu F,Chen XY,Song B,et al. Influence of dosage forms on pharmacokinetics of daidzein and its main metabolite daidzein-7-O-glucuronide in rats[J]. ACTA PHARMACOLOGICA SINICA,2005,26(9):1145-1152.
APA Qiu F,Chen XY,Song B,Zhong DF,&Liu CX.(2005).Influence of dosage forms on pharmacokinetics of daidzein and its main metabolite daidzein-7-O-glucuronide in rats.ACTA PHARMACOLOGICA SINICA,26(9),1145-1152.
MLA Qiu F,et al."Influence of dosage forms on pharmacokinetics of daidzein and its main metabolite daidzein-7-O-glucuronide in rats".ACTA PHARMACOLOGICA SINICA 26.9(2005):1145-1152.
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