Application of high performance capillary electrophoresis tandem mass spectrometry to the investigation on the stability of novel anticancer platinum complex in solution

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	Application of high performance capillary electrophoresis tandem mass spectrometry to the investigation on the stability of novel anticancer platinum complex in solution
其他题名	Application of High Performance Capillary Electrophoresis Tandem Mass Spectrometry to the Investigation on the Stability of Novel Anticancer Platinum Complex in Solution
	Qiang Su 1; QingFei Liu 1; JuanFang Wu 1; YiMing Wang 1; KaiShun Bi 2; WeiPing Liu 3; GuoAn Luo 1
	2007
发表期刊	CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
ISSN	0253-3820
卷号	35 期号:12 页码:1721-1725
摘要	The stability of novel anticancer platinum complex in solution, named as cis-3,5-diisopropylsalicilyco-(1R,2R-cyclodiamino) Pt(II), or SM 54111 for short, was investigated. The platinum complex was designed, synthesized, and characterized by element analysis, coupled inductively plasma mass spectrometry, gravitational thermal-differential thermal analysis, ultraviolet-visible absorption spectrometry, infrared specos-copy, fast atom bombment mass spectrometry and H-1 nuclear magnetic resonance, etc. High performance capillary electrophoresis-electrospray ionization-mass spectrometry(HPCE-ESI-MSn) was employed to separate the platinum complex and the possible products of dissociation, to identify and quantify as well. It shows that this novel compound remains prototype at the range of pH 5.0-9.0. At pH value lower than 5.0, SM54111 disassociates by clearage producing monodentate platinum complex which was detected and identified with ESI-MSn. A type of novel cleavage was obtained by the compound tested, which indicated that the ionization rate depended on the ionization codition. It was proved that SM54111's stability at physiological pH in solution was demonstrated and HPCE-EST-MS/MS was a convenient and useful tool for the analysis of platinum complex. The results offered the method and reference for the study on the pharmacokinetics and pharmacology of SM54111.
关键词	ATOMIC EMISSION-SPECTROMETRY CISPLATIN high performance capillary electrophoresis electrospray ionization mass spectrometry platinum complex stability anticancer compound
收录类别	CSCD
语种	英语
CSCD记录号	CSCD:3044360
引用统计
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/146725
专题	中国科学院金属研究所
作者单位	1.清华大学 2.中国科学院金属研究所 3.Kunming Institute Precious Met, Kunming 650221, Peoples R China
推荐引用方式 GB/T 7714	Qiang Su,QingFei Liu,JuanFang Wu,et al. Application of high performance capillary electrophoresis tandem mass spectrometry to the investigation on the stability of novel anticancer platinum complex in solution[J]. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,2007,35(12):1721-1725.
APA	Qiang Su.,QingFei Liu.,JuanFang Wu.,YiMing Wang.,KaiShun Bi.,...&GuoAn Luo.(2007).Application of high performance capillary electrophoresis tandem mass spectrometry to the investigation on the stability of novel anticancer platinum complex in solution.CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,35(12),1721-1725.
MLA	Qiang Su,et al."Application of high performance capillary electrophoresis tandem mass spectrometry to the investigation on the stability of novel anticancer platinum complex in solution".CHINESE JOURNAL OF ANALYTICAL CHEMISTRY 35.12(2007):1721-1725.