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Application of high performance capillary electrophoresis tandem mass spectrometry to the investigation on the stability of novel anticancer platinum complex in solution
Alternative TitleApplication of High Performance Capillary Electrophoresis Tandem Mass Spectrometry to the Investigation on the Stability of Novel Anticancer Platinum Complex in Solution
Qiang Su1; QingFei Liu1; JuanFang Wu1; YiMing Wang1; KaiShun Bi2; WeiPing Liu3; GuoAn Luo1
2007
Source PublicationCHINESE JOURNAL OF ANALYTICAL CHEMISTRY
ISSN0253-3820
Volume35Issue:12Pages:1721-1725
AbstractThe stability of novel anticancer platinum complex in solution, named as cis-3,5-diisopropylsalicilyco-(1R,2R-cyclodiamino) Pt(II), or SM 54111 for short, was investigated. The platinum complex was designed, synthesized, and characterized by element analysis, coupled inductively plasma mass spectrometry, gravitational thermal-differential thermal analysis, ultraviolet-visible absorption spectrometry, infrared specos-copy, fast atom bombment mass spectrometry and H-1 nuclear magnetic resonance, etc. High performance capillary electrophoresis-electrospray ionization-mass spectrometry(HPCE-ESI-MSn) was employed to separate the platinum complex and the possible products of dissociation, to identify and quantify as well. It shows that this novel compound remains prototype at the range of pH 5.0-9.0. At pH value lower than 5.0, SM54111 disassociates by clearage producing monodentate platinum complex which was detected and identified with ESI-MSn. A type of novel cleavage was obtained by the compound tested, which indicated that the ionization rate depended on the ionization codition. It was proved that SM54111's stability at physiological pH in solution was demonstrated and HPCE-EST-MS/MS was a convenient and useful tool for the analysis of platinum complex. The results offered the method and reference for the study on the pharmacokinetics and pharmacology of SM54111.
KeywordATOMIC EMISSION-SPECTROMETRY CISPLATIN high performance capillary electrophoresis electrospray ionization mass spectrometry platinum complex stability anticancer compound
Indexed ByCSCD
Language英语
CSCD IDCSCD:3044360
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Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/146727
Collection中国科学院金属研究所
Affiliation1.清华大学
2.中国科学院金属研究所
3.Kunming Institute Precious Met, Kunming 650221, Peoples R China
Recommended Citation
GB/T 7714
Qiang Su,QingFei Liu,JuanFang Wu,et al. Application of high performance capillary electrophoresis tandem mass spectrometry to the investigation on the stability of novel anticancer platinum complex in solution[J]. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,2007,35(12):1721-1725.
APA Qiang Su.,QingFei Liu.,JuanFang Wu.,YiMing Wang.,KaiShun Bi.,...&GuoAn Luo.(2007).Application of high performance capillary electrophoresis tandem mass spectrometry to the investigation on the stability of novel anticancer platinum complex in solution.CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,35(12),1721-1725.
MLA Qiang Su,et al."Application of high performance capillary electrophoresis tandem mass spectrometry to the investigation on the stability of novel anticancer platinum complex in solution".CHINESE JOURNAL OF ANALYTICAL CHEMISTRY 35.12(2007):1721-1725.
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