Applicability of various estimation formulas to assess renal function in Chinese children

IMR OpenIR

	Applicability of various estimation formulas to assess renal function in Chinese children
其他题名	Applicability of various estimation formulas to assess renal function in Chinese children
	Du Yue; Sun TingTing; Hou Ling; Guo JinJie; Wang XiuLi; Wu YuBin
	2015
发表期刊	WORLD JOURNAL OF PEDIATRICS
ISSN	1708-8569
卷号	11 期号:4 页码:346-351
摘要	This study was to evaluate the relative applicability of the most commonly used estimation formulas for renal glomerular filtration rate (GFR) of Chinese children with chronic kidney disease (CKD).
其他摘要	Background: This study was to evaluate the relative applicability of the most commonly used estimation formulas for renal glomerular filtration rate (GFR)of Chinese children with chronic kidney disease (CKD). Methods: One hundred CKD patients of less than 17 years old were divided into two groups by sex which was further categorized into five subgroups based on CKD staging according to the "reference" GFR (rGFR)determined by Tc-99m-DTPA renal dynamic imaging. Four GFR markers including serum cystatin C (CysC), β2-microglobulin, creatinine, and blood urea nitrogen were measured. Results: Among all four markers, CysC best reflected the extent of glomerular damages for CKD stage 1. The value for estimation of GFR (eGFR)was derived from five different formulas either over-estimated or underestimated GFR as referenced to rGFR, and the extent of deviations was dependent on gender, age and CKD stage. The Counahan-Barratt formula and the Schwartz formula gave the most accurate estimations of GFR for CKD stages 1 and 2-3, respectively regardless of gender and age differences. Receiver operating characteristic analyses indicated that the Counahan-Barratt formula has the highest diagnostic accuracy. Conclusion: The Counahan-Barratt formula provides the best approximation to rGFR, thereby the highest applicability to Chinese children with CKD of different genders, ages and CKD stages.
关键词	GLOMERULAR-FILTRATION-RATE PLASMA CREATININE CONCENTRATION BETA-TRACE-PROTEIN CYSTATIN-C SERUM CREATININE COCKCROFT-GAULT GFR RADIONUCLIDES NEPHROUROLOGY ADOLESCENTS chronic kidney disease Counahan-Barratt formula cystatin C renal glomerular filtration rate Schwartz formula
收录类别	CSCD
语种	英语
CSCD记录号	CSCD:5545179
引用统计	被引频次：2[CSCD] [CSCD记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/146736
专题	中国科学院金属研究所
作者单位	中国科学院金属研究所
推荐引用方式 GB/T 7714	Du Yue,Sun TingTing,Hou Ling,et al. Applicability of various estimation formulas to assess renal function in Chinese children[J]. WORLD JOURNAL OF PEDIATRICS,2015,11(4):346-351.
APA	Du Yue,Sun TingTing,Hou Ling,Guo JinJie,Wang XiuLi,&Wu YuBin.(2015).Applicability of various estimation formulas to assess renal function in Chinese children.WORLD JOURNAL OF PEDIATRICS,11(4),346-351.
MLA	Du Yue,et al."Applicability of various estimation formulas to assess renal function in Chinese children".WORLD JOURNAL OF PEDIATRICS 11.4(2015):346-351.