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Applicability of various estimation formulas to assess renal function in Chinese children
Alternative TitleApplicability of various estimation formulas to assess renal function in Chinese children
Du Yue; Sun TingTing; Hou Ling; Guo JinJie; Wang XiuLi; Wu YuBin
2015
Source PublicationWORLD JOURNAL OF PEDIATRICS
ISSN1708-8569
Volume11Issue:4Pages:346-351
AbstractThis study was to evaluate the relative applicability of the most commonly used estimation formulas for renal glomerular filtration rate (GFR) of Chinese children with chronic kidney disease (CKD).
Other AbstractBackground: This study was to evaluate the relative applicability of the most commonly used estimation formulas for renal glomerular filtration rate (GFR)of Chinese children with chronic kidney disease (CKD). Methods: One hundred CKD patients of less than 17 years old were divided into two groups by sex which was further categorized into five subgroups based on CKD staging according to the "reference" GFR (rGFR)determined by Tc-99m-DTPA renal dynamic imaging. Four GFR markers including serum cystatin C (CysC), β2-microglobulin, creatinine, and blood urea nitrogen were measured. Results: Among all four markers, CysC best reflected the extent of glomerular damages for CKD stage 1. The value for estimation of GFR (eGFR)was derived from five different formulas either over-estimated or underestimated GFR as referenced to rGFR, and the extent of deviations was dependent on gender, age and CKD stage. The Counahan-Barratt formula and the Schwartz formula gave the most accurate estimations of GFR for CKD stages 1 and 2-3, respectively regardless of gender and age differences. Receiver operating characteristic analyses indicated that the Counahan-Barratt formula has the highest diagnostic accuracy. Conclusion: The Counahan-Barratt formula provides the best approximation to rGFR, thereby the highest applicability to Chinese children with CKD of different genders, ages and CKD stages.
KeywordGLOMERULAR-FILTRATION-RATE PLASMA CREATININE CONCENTRATION BETA-TRACE-PROTEIN CYSTATIN-C SERUM CREATININE COCKCROFT-GAULT GFR RADIONUCLIDES NEPHROUROLOGY ADOLESCENTS chronic kidney disease Counahan-Barratt formula cystatin C renal glomerular filtration rate Schwartz formula
Indexed ByCSCD
Language英语
CSCD IDCSCD:5545179
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Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/146738
Collection中国科学院金属研究所
Affiliation中国科学院金属研究所
Recommended Citation
GB/T 7714
Du Yue,Sun TingTing,Hou Ling,et al. Applicability of various estimation formulas to assess renal function in Chinese children[J]. WORLD JOURNAL OF PEDIATRICS,2015,11(4):346-351.
APA Du Yue,Sun TingTing,Hou Ling,Guo JinJie,Wang XiuLi,&Wu YuBin.(2015).Applicability of various estimation formulas to assess renal function in Chinese children.WORLD JOURNAL OF PEDIATRICS,11(4),346-351.
MLA Du Yue,et al."Applicability of various estimation formulas to assess renal function in Chinese children".WORLD JOURNAL OF PEDIATRICS 11.4(2015):346-351.
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