| Syntheses and Antiproliferative Activities of Novel Diarylthiosemicarbazide Derivatives | |
| Alternative Title | Syntheses and Antiproliferative Activities of Novel Diarylthiosemicarbazide Derivatives |
| Zhai Xin; He Ying; Yang Zhen; Gong Ping | |
| 2013 | |
| Source Publication | CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
 |
| ISSN | 1005-9040 |
| Volume | 29Issue:1Pages:62-66 |
| Abstract | A series of novel N-methylpicolinamide-moiety containing diarylthiosemicarbazide derivatives was prepared and evaluated for their in vitro antiproliferative activity against three cancer cell lines(human alveolar epithelial cell A549, human lung cancer cell 11460 and human colorectal cancer cell HT-29) by 3-(4,5-dimethyl)thiazolyl-diphenyltetrazoliumromide(MTT) assay. Six compounds(7b-7g) with halogen substituents exhibited preferable cytotoxicity against one or more cell lines in a low micromolar range. Especially, the most promising compound 7g exhibited remarkable antiproliferative activity with the IC50 values of 2.2, 1.8 and 5.2 mu mol/L against A549, 11460 and HT-29 cell lines respectively, which is comparable to sorafenib. |
| Other Abstract | A series of novel N-methylpicolinamide-moiety containing diarylthiosemicarbazide derivatives was prepared and evaluated for their in vitro antiproliferative activity against three cancer cell lines(human alveolar epithelial cell A549,human lung cancer cell H460 and human colorectal cancer cell HT-29) by 3-(4,5-dimethyl)thiazolyl- diphenyltetrazoliumromide(MTT) assay. Six compounds(7b―7g) with halogen substituents exhibited preferable cytotoxicity against one or more cell lines in a low micromolar range. Especially,the most promising compound 7g exhibited remarkable antiproliferative activity with the IC50 values of 2.2,1.8 and 5.2 μmol/L against A549,H460 and HT-29 cell lines respectively,which is comparable to sorafenib. |
| Keyword | KINASE INHIBITORS ANTITUMOR AGENTS DESIGN BENZIMIDAZOLES CYTOTOXICITY Thiosemicarbazide N-methylpicolinamide Antiproliferative activity |
| Indexed By | CSCD |
| Language | 英语 |
| Funding Project | [National Natural Science Foundation of China] ; [Science & Technology Project of Liaoning Province, China] |
| CSCD ID | CSCD:4756394 |
| Citation statistics |
Cited Times:4[CSCD]
[CSCD Record]
|
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/146988 |
| Collection | 中国科学院金属研究所 |
| Affiliation | 中国科学院金属研究所 |
| Recommended Citation GB/T 7714 | Zhai Xin,He Ying,Yang Zhen,et al. Syntheses and Antiproliferative Activities of Novel Diarylthiosemicarbazide Derivatives[J]. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2013,29(1):62-66. |
| APA | Zhai Xin,He Ying,Yang Zhen,&Gong Ping.(2013).Syntheses and Antiproliferative Activities of Novel Diarylthiosemicarbazide Derivatives.CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,29(1),62-66. |
| MLA | Zhai Xin,et al."Syntheses and Antiproliferative Activities of Novel Diarylthiosemicarbazide Derivatives".CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 29.1(2013):62-66. |
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