Association of tag SNPs of GPx-3 with essential hypertension in rural Han Chinese in Fuxin, Liaoning, China

IMR OpenIR

	Association of tag SNPs of GPx-3 with essential hypertension in rural Han Chinese in Fuxin, Liaoning, China
其他题名	Association of tag SNPs of GPx-3 with essential hypertension in rural Han Chinese in Fuxin,Liaoning,China
	Hao Ying; Wu Baogang; Shi Jin; Chen Yanli; Sun Zhaoqing; Zheng Liqiang; Zhang Xingang; Geng Ning; Li Tiejun; Li Hong; Sun Yingxian
	2011
发表期刊	CHINESE MEDICAL JOURNAL
ISSN	0366-6999
卷号	124 期号:14 页码:2113-2116
摘要	Background Genetic mechanisms contribute to blood pressure regulation. This study investigated whether glutathione peroxidase (GPx-3) tag single nucleotide polymorphisms (SNPs) are associated with hypertension in the rural areas of Fuxin county, Liaoning province, China.
其他摘要	Background Genetic mechanisms contribute to blood pressure regulation.This study investigated whether glutathione peroxidase (GPx-3)tag single nucleotide polymorphisms (SNPs)are associated with hypertension in the rural areas of Fuxin county,Liaoning province,China.Methods Indigenous Fuxin Han people participated,523 unrelated hypertensives and 547 controls were recruited.All tag SNPs of GPx-3 gene were selected.We estimated SNP allele frequency in DNA pools with pyrosequencing.Results Before Bonferroni correction,C allele frequency for rs8177417 was significantly higher in hypertensives than those in controls (23.4% vs.19.3%,P=0.014); T allele frequency for rs3828599 was significantly lower in hypertensives than those in controls (35.6% vs.40.8%,P=0.009).However,when a Bonferroni correction for multiple testing was applied,only the polymorphisms rs3828599 of GPx-3 gene was associated with hypertension (P=0.045,OR:0.833,95% Cl:0.695-0.998).Conclusion The polymorphism of rs3828599 of GPx-3 gene might be associated with hypertension in rural Han Chinese from Fuxin,Liaoning.
关键词	SALT-SENSITIVE HYPERTENSION ARTERIAL ISCHEMIC-STROKE PROMOTER POLYMORPHISMS ALLELE FREQUENCY OXIDATIVE STRESS BLOOD-PRESSURE RISK-FACTOR DNA POOLS PEROXIDASE GENE hypertension Han Chinese GPx-3 gene association
收录类别	CSCD
语种	英语
资助项目	[Ministry of Science and Technology, China]
CSCD记录号	CSCD:4319811
引用统计	被引频次：4[CSCD] [CSCD记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/147030
专题	中国科学院金属研究所
作者单位	中国科学院金属研究所
推荐引用方式 GB/T 7714	Hao Ying,Wu Baogang,Shi Jin,et al. Association of tag SNPs of GPx-3 with essential hypertension in rural Han Chinese in Fuxin, Liaoning, China[J]. CHINESE MEDICAL JOURNAL,2011,124(14):2113-2116.
APA	Hao Ying.,Wu Baogang.,Shi Jin.,Chen Yanli.,Sun Zhaoqing.,...&Sun Yingxian.(2011).Association of tag SNPs of GPx-3 with essential hypertension in rural Han Chinese in Fuxin, Liaoning, China.CHINESE MEDICAL JOURNAL,124(14),2113-2116.
MLA	Hao Ying,et al."Association of tag SNPs of GPx-3 with essential hypertension in rural Han Chinese in Fuxin, Liaoning, China".CHINESE MEDICAL JOURNAL 124.14(2011):2113-2116.