The cytoplasmic droplet may be indicative of sperm motility and normal spermiogenesis

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	The cytoplasmic droplet may be indicative of sperm motility and normal spermiogenesis
其他题名	The cytoplasmic droplet may be indicative of sperm motility and normal spermiogenesis
	Xu Hui 1; Yuan ShuiQiao 1; Zheng ZhiHong 1; Yan Wei 1
	2013
发表期刊	ASIAN JOURNAL OF ANDROLOGY
ISSN	1008-682X
卷号	15 期号:6 页码:799-805
摘要	Although the cytoplasm of spermatids is removed at the end of spermiogenesis, a tiny portion is usually retained in the sperm flagellum, which is termed the cytoplasmic droplet (CD) in mammals. CDs are believed to play a role in sperm volume adaptation. However, we have noticed that epididymal spermatozoa that display initial (flagellation in situ) and progressive motility mostly possess CDs, whereas spermatozoa without CDs are rarely motile, suggesting that CDs have a role in motility development during sperm epididymal maturation. In the present study, we analyzed the relationship between the presence or absence of CDs, motility development and positional changes of CDs during sperm epididymal maturation in mice and monkeys. We also examined CDs on spermatozoa of three knockout mouse lines with late spermiogenic defects. Our data suggest that the CD is a normal organelle transiently present exclusively on epididymal spermatozoa, and normal CD morphology and location are associated with normal motility development during epididymal maturation of spermatozoa. Abnormal CD formation, e.g., a complete lack of CDs or ectopic CDs, is indicative of defective spermiogenesis. If CDs are essential for sperm motility development, then CDs may represent an ideal drug target for the development of non-hormonal male contraceptives.
其他摘要	Although the cytoplasm of spermatids is removed at the end of spermiogenesis, a tiny portion is usually retained in the sperm flagellum, which is termed the cytoplasmic droplet (CD) in mammals. CDs are believed to play a role in sperm volume adaptation. However, we have noticed that epididymal spermatozoa that display initial (flagellation in situ ) and progressive motility mostly possess CDs, whereas spermatozoa without CDs are rarely motile, suggesting that CDs have a role in motility development during sperm epididymal maturation. In the present study, we analyzed the relationship between the presence or absence of CDs, motility development and positional changes of CDs during sperm epididymal maturation in mice and monkeys. We also examined CDs on spermatozoa of three knockout mouse lines with late spermiogenic defects. Our data suggest that the CD is a normal organelle transiently present exclusively on epididymal spermatozoa, and normal CD morphology and location are associated with normal motility development during epididymal maturation of spermatozoa. Abnormal CD formation, e.g., a complete lack of CDs or ectopic CDs, is indicative of defective spermiogenesis. If CDs are essential for sperm motility development, then CDs may represent an ideal drug target for the development of non-hormonal male contraceptives.
关键词	HUMAN SPERMATOZOA ALKALINE-PHOSPHATASE VOLUME REGULATION MALE-INFERTILITY LIFE-HISTORY RAT SPERMATOGENESIS EPIDIDYMIS ENZYMES MOUSE cytoplasmic droplets epididymis fertility mouse semen analysis spermiogenesis sperm motility
收录类别	CSCD
语种	英语
资助项目	[startup funds from the University of Nevada, Reno]
CSCD记录号	CSCD:4960262
引用统计	被引频次：5[CSCD] [CSCD记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/147135
专题	中国科学院金属研究所
作者单位	1.中国科学院金属研究所 2.华东师范大学
推荐引用方式 GB/T 7714	Xu Hui,Yuan ShuiQiao,Zheng ZhiHong,et al. The cytoplasmic droplet may be indicative of sperm motility and normal spermiogenesis[J]. ASIAN JOURNAL OF ANDROLOGY,2013,15(6):799-805.
APA	Xu Hui,Yuan ShuiQiao,Zheng ZhiHong,&Yan Wei.(2013).The cytoplasmic droplet may be indicative of sperm motility and normal spermiogenesis.ASIAN JOURNAL OF ANDROLOGY,15(6),799-805.
MLA	Xu Hui,et al."The cytoplasmic droplet may be indicative of sperm motility and normal spermiogenesis".ASIAN JOURNAL OF ANDROLOGY 15.6(2013):799-805.