IMR OpenIR
Effects of l-tetrahydropalmatine on locomotor sensitization to oxycodone in mice
Alternative TitleEffects of l-tetrahydropalmatine on locomotor sensitization to oxycodone in mice
Liu YL1; Liang JH1; Yan LD1; Su RB1; Wu CF1; Gong ZH1
2005
Source PublicationACTA PHARMACOLOGICA SINICA
ISSN1671-4083
Volume26Issue:5Pages:533-538
AbstractAim: Recent studies have shown that 1-tetrahydropalmatine (l-THP), an active component of Corydolis yanhusuo, can inhibit the development of the conditional place preference induced by opioid receptor agonists, but the effects of l-THP on locomotor sensitivity induced by opioid receptor agonists have not been documented. In the present study, the effects of l-THP on locomotor sensitization to oxycodone, which is an opioid receptor agonist, were studied. Methods: Mice treated daily for 7 d with 5 mg/kg oxycodone and challenged with the same dose after 5 days of washout showed locomotor sensitization. In order to study the effects of l-THP on locomotor sensitization induced by oxycodone, l-THP was administered at doses of 6.25, 12.5, and 18.75 mg/kg, 40 min prior to treatment of oxycodone. Results: l-THP per se did not affect the locomotor activity at the doses of 6.25, 12.5, and 18.75 mg/kg, but could antagonize the hyperactivity induced by oxycodone (5 mg/kg). Co-administration of l-THP (18.75 mg/kg), 40 min prior to oxycodone, could inhibit the development of sensitization to oxycodone. In addition, l-THP (6.25, 12.5, and 18.75 mg/kg, ig) dose-dependently prevented the expression of oxycodone sensitization. Conclusion: These results suggested that l-THP could attenuate the locomotor-stimulating effects of oxycodone and inhibit the development and expression of oxycodone behavioral sensitization.
Other AbstractAim: Recent studies have shown that l-tetrahydropalmatine (l-THP), an active component of Corydolis yanhusuo, can inhibit the development of the conditional place preference induced by opioid receptor agonists, but the effects of l-THP on locomotor sensitivity induced by opioid receptor agonists have not been documented. In the present study, the effects of l-THP on locomotor sensitization to oxycodone, which is an opioid receptor agonist, were studied. Methods: Mice treated daily for 7 d with 5 mg/kg oxycodone and challenged with the same dose after 5 days of washout showed locomotor sensitization. In order to study the effects of l-THP on locomotor sensitization induced by oxycodone, l-THP was administered at doses of 6.25, 12.5, and 18.75 mg/kg, 40 min prior to treatment of oxycodone. Results: l-THP per se did not affect the locomotor activity at the doses of 6.25, 12.5, and 18.75 mg/kg, but could antagonize the hyperactivity induced by oxycodone (5 mg/kg). Co-administration of l-THP (18.75 mg/kg), 40 min prior to oxycodone, could inhibit the development of sensitization to oxycodone. In addition, l-THP (6.25, 12.5, and 18.75 mg/kg, ig) dose-dependently prevented the expression of oxycodone sensitization. Conclusion: These results suggested that l-THP could attenuate the locomotor-stimulating effects of oxycodone and inhibit the development and expression of oxycodone behavioral sensitization.
KeywordDOPAMINE-RECEPTOR ANTAGONISTS CALCIUM-CHANNEL INHIBITORS BEHAVIORAL SENSITIZATION MORPHINE EXPRESSION ADDICTION COCAINE RATS BLOCKERS HEROIN l-tetrahydropalmatine oxycodone locomotor sensitization
Indexed ByCSCD
Language英语
CSCD IDCSCD:2038650
Citation statistics
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/147304
Collection中国科学院金属研究所
Affiliation1.Beijing Institute Pharmacol & Toxicol
2.中国科学院金属研究所
3.北京大学
Recommended Citation
GB/T 7714
Liu YL,Liang JH,Yan LD,et al. Effects of l-tetrahydropalmatine on locomotor sensitization to oxycodone in mice[J]. ACTA PHARMACOLOGICA SINICA,2005,26(5):533-538.
APA Liu YL,Liang JH,Yan LD,Su RB,Wu CF,&Gong ZH.(2005).Effects of l-tetrahydropalmatine on locomotor sensitization to oxycodone in mice.ACTA PHARMACOLOGICA SINICA,26(5),533-538.
MLA Liu YL,et al."Effects of l-tetrahydropalmatine on locomotor sensitization to oxycodone in mice".ACTA PHARMACOLOGICA SINICA 26.5(2005):533-538.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Liu YL]'s Articles
[Liang JH]'s Articles
[Yan LD]'s Articles
Baidu academic
Similar articles in Baidu academic
[Liu YL]'s Articles
[Liang JH]'s Articles
[Yan LD]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Liu YL]'s Articles
[Liang JH]'s Articles
[Yan LD]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.