| Effects of l-tetrahydropalmatine on locomotor sensitization to oxycodone in mice | |
| Alternative Title | Effects of l-tetrahydropalmatine on locomotor sensitization to oxycodone in mice |
| Liu YL1; Liang JH1; Yan LD1; Su RB1; Wu CF1; Gong ZH1 | |
| 2005 | |
| Source Publication | ACTA PHARMACOLOGICA SINICA
 |
| ISSN | 1671-4083 |
| Volume | 26Issue:5Pages:533-538 |
| Abstract | Aim: Recent studies have shown that 1-tetrahydropalmatine (l-THP), an active component of Corydolis yanhusuo, can inhibit the development of the conditional place preference induced by opioid receptor agonists, but the effects of l-THP on locomotor sensitivity induced by opioid receptor agonists have not been documented. In the present study, the effects of l-THP on locomotor sensitization to oxycodone, which is an opioid receptor agonist, were studied. Methods: Mice treated daily for 7 d with 5 mg/kg oxycodone and challenged with the same dose after 5 days of washout showed locomotor sensitization. In order to study the effects of l-THP on locomotor sensitization induced by oxycodone, l-THP was administered at doses of 6.25, 12.5, and 18.75 mg/kg, 40 min prior to treatment of oxycodone. Results: l-THP per se did not affect the locomotor activity at the doses of 6.25, 12.5, and 18.75 mg/kg, but could antagonize the hyperactivity induced by oxycodone (5 mg/kg). Co-administration of l-THP (18.75 mg/kg), 40 min prior to oxycodone, could inhibit the development of sensitization to oxycodone. In addition, l-THP (6.25, 12.5, and 18.75 mg/kg, ig) dose-dependently prevented the expression of oxycodone sensitization. Conclusion: These results suggested that l-THP could attenuate the locomotor-stimulating effects of oxycodone and inhibit the development and expression of oxycodone behavioral sensitization. |
| Other Abstract | Aim: Recent studies have shown that l-tetrahydropalmatine (l-THP), an active component of Corydolis yanhusuo, can inhibit the development of the conditional place preference induced by opioid receptor agonists, but the effects of l-THP on locomotor sensitivity induced by opioid receptor agonists have not been documented. In the present study, the effects of l-THP on locomotor sensitization to oxycodone, which is an opioid receptor agonist, were studied. Methods: Mice treated daily for 7 d with 5 mg/kg oxycodone and challenged with the same dose after 5 days of washout showed locomotor sensitization. In order to study the effects of l-THP on locomotor sensitization induced by oxycodone, l-THP was administered at doses of 6.25, 12.5, and 18.75 mg/kg, 40 min prior to treatment of oxycodone. Results: l-THP per se did not affect the locomotor activity at the doses of 6.25, 12.5, and 18.75 mg/kg, but could antagonize the hyperactivity induced by oxycodone (5 mg/kg). Co-administration of l-THP (18.75 mg/kg), 40 min prior to oxycodone, could inhibit the development of sensitization to oxycodone. In addition, l-THP (6.25, 12.5, and 18.75 mg/kg, ig) dose-dependently prevented the expression of oxycodone sensitization. Conclusion: These results suggested that l-THP could attenuate the locomotor-stimulating effects of oxycodone and inhibit the development and expression of oxycodone behavioral sensitization. |
| Keyword | DOPAMINE-RECEPTOR ANTAGONISTS CALCIUM-CHANNEL INHIBITORS BEHAVIORAL SENSITIZATION MORPHINE EXPRESSION ADDICTION COCAINE RATS BLOCKERS HEROIN l-tetrahydropalmatine oxycodone locomotor sensitization |
| Indexed By | CSCD |
| Language | 英语 |
| CSCD ID | CSCD:2038650 |
| Citation statistics |
Cited Times:6[CSCD]
[CSCD Record]
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| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/147304 |
| Collection | 中国科学院金属研究所 |
| Affiliation | 1.Beijing Institute Pharmacol & Toxicol 2.中国科学院金属研究所 3.北京大学 |
| Recommended Citation GB/T 7714 | Liu YL,Liang JH,Yan LD,et al. Effects of l-tetrahydropalmatine on locomotor sensitization to oxycodone in mice[J]. ACTA PHARMACOLOGICA SINICA,2005,26(5):533-538. |
| APA | Liu YL,Liang JH,Yan LD,Su RB,Wu CF,&Gong ZH.(2005).Effects of l-tetrahydropalmatine on locomotor sensitization to oxycodone in mice.ACTA PHARMACOLOGICA SINICA,26(5),533-538. |
| MLA | Liu YL,et al."Effects of l-tetrahydropalmatine on locomotor sensitization to oxycodone in mice".ACTA PHARMACOLOGICA SINICA 26.5(2005):533-538. |
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