Association of Helicobacter pylori babA2 with peptic ulcer disease and gastric cancer

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	Association of Helicobacter pylori babA2 with peptic ulcer disease and gastric cancer
其他题名	Association of Helicobacter pylori babA2 with peptic ulcer disease and gastric cancer
	Chen MoYe; He CaiYun; Meng Xue; Yuan Yuan
	2013
发表期刊	WORLD JOURNAL OF GASTROENTEROLOGY
ISSN	1007-9327
卷号	19 期号:26 页码:4242-4251
摘要	AIM: To investigate the association between babA2 gene and peptic ulcer disease (PUD) and gastric cancer (GC) in Helicobacter pylori-infected populations.
其他摘要	AIM: To investigate the association between babA2 gene and peptic ulcer disease (PUD) and gastric cancer (GC) in Helicobacter pylori -infected populations. METHODS: We evaluated the relationship between babA2 and clinical outcomes (PUD and GC) using a meta-analysis. A literature search was performed using the PubMed and Web of Science databases for relevant case-control studies that met the defined inclusion criteria. The ORs and 95%CIs were calculated to estimate the association between babA2 genotype and clinical outcomes. A fixed-effect or random-effect model was performed depending on the absence or presence of significant heterogeneity. RESULTS: A total of 25 articles with 38 studies met the inclusion criteria and were finally included in this metaanalysis. The results showed that the babA2 genotype was significantly associated with an increased risk of PUD (OR = 2.069, 95%CI: 1.530-2.794, P < 0.001) and especially in the subgroup of duodenal ulcer (OR = 1.588, 95%CI: 1.141-2.209, P = 0.006). Moreover, a significant association between babA2 gene and PUD and duodenal ulcer (OR = 2.739, 95%CI: 1.860-4.032, P < 0.001; OR = 2.239, 95%CI: 1.468-3.415, P < 0.001, respectively) was observed in western countries but not in Asian countries. CONCLUSION: We demonstrated that the presence of babA2 may be associated with increased risks for PUD, especially duodenal ulcer, in western countries.
关键词	HELICOBACTER-PYLORI INFECTION ANTIGEN-BINDING ADHESIN DUODENAL-ULCER VIRULENCE FACTORS CLINICAL-RELEVANCE BABA2 GENOTYPES TURKISH PATIENTS CAGA PREVALENCE VACA Helicobacter pylori babA2 Peptic ulcer Gastric cancer Risk
收录类别	CSCD
语种	英语
资助项目	[National Basic Research Program of China, 973 Program] ; [Grants of the Science and Technology Project of Liaoning province] ; [Grants of the Science Project of Liaoning Province]
CSCD记录号	CSCD:5009512
引用统计
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/147365
专题	中国科学院金属研究所
作者单位	中国科学院金属研究所
推荐引用方式 GB/T 7714	Chen MoYe,He CaiYun,Meng Xue,et al. Association of Helicobacter pylori babA2 with peptic ulcer disease and gastric cancer[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2013,19(26):4242-4251.
APA	Chen MoYe,He CaiYun,Meng Xue,&Yuan Yuan.(2013).Association of Helicobacter pylori babA2 with peptic ulcer disease and gastric cancer.WORLD JOURNAL OF GASTROENTEROLOGY,19(26),4242-4251.
MLA	Chen MoYe,et al."Association of Helicobacter pylori babA2 with peptic ulcer disease and gastric cancer".WORLD JOURNAL OF GASTROENTEROLOGY 19.26(2013):4242-4251.