IMR OpenIR
Expression of Elk-1 in non-small cell lung cancer detected by western blot and tissue microarray
Alternative TitleExpression of Elk-1 in Non-Small Cell Lung Cancer Detected by Western Blot and Tissue Microarray
Zhang Shuguang1; Li Fang2; Li Wenya1; Lu Wei1; Zhang Lin1
2007
Source PublicationCHINESE JOURNAL OF CANCER RESEARCH
ISSN1000-9604
Volume19Issue:1Pages:7-11
AbstractObjective: The aim of this study was to investigate the Elk- 1 ( Ets like transcription factor- 1) expression in non- small cell lung cancer ( NSCLC) and normal lung tissues and the relationship between its expression and clinicopathological characters. Methods: To observe Elk- 1 expression, western blot and immunochemistry ( IHC) on tissue microarray ( TMA) containing 118 lung cancers and their corresponding normal tissues were used. Results: In western blot and IHC on TMA, Elk- 1 was highly expressed in NSCLC, while its expression was almost undetectable in normal lung tissues. Elk- 1 expression in NSCLC had no relationship with the patients' age, gender, smoking status and histological type, but had relationship with the differentiation degree, clinical stages and lymphonode metastasis. The expression was lower in early stage group ( I+ II) than in advanced stage group ( III), and lower in well- moderately differentiated group than in poorly differentiated group. The same trend was seen with lymphonode metastasis. Conclusion: The progression of NSCLC may be related with the increased Elk- 1 expression, and Elk- 1 may be regarded as a prognostic factor for NSCLC tissues.
Other AbstractObjective: The aim of this study was to investigate the Elk-1 (Ets like transcription factor-1) expression in non-small cell lung cancer (NSCLC) and normal lung tissues and the relationship between its expression and clinicopathological characters. Methods: To observe Elk-1 expression, western blot and immunochemistry (IHC) on tissue microarray (TMA) containing 118 lung cancers and their corresponding normal tissues were used. Results: In western blot and IHC on TMA, Elk-1 was highly expressed in NSCLC, while its expression was almost undetectable in normal lung tissues. Elk-1 expression in NSCLC had no relationship with the patients' age, gender, smoking status and histological type, but had relationship with the differentiation degree, clinical stages and lymphonode metastasis. The expression was lower in early stage group (I+II) than in advanced stage group (III), and lower in well-moderately differentiated group than in poorly differentiated group. The same trend was seen with lymphonode metastasis. Conclusion: The progression of NSCLC may be related with the increased Elk-1 expression, and Elk-1 may be regarded as a prognostic factor for NSCLC tissues.
KeywordTERNARY COMPLEX FACTORS TRANSCRIPTION FACTORS ETS Elk-1 non-small cell lung cancer western blot immunohistochemistry tissue microarray
Indexed ByCSCD
Language英语
CSCD IDCSCD:2920359
Citation statistics
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/147428
Collection中国科学院金属研究所
Affiliation1.中国科学院金属研究所
2.Chinese Acad Med Sci, Dept Thorac Surg, Institute Canc, Beijing 100021, Peoples R China Dept Thorac Surg Institute Canc
3.中国医学科学院
4.Peking Union Med Coll, Beijing 100021, Peoples R China
Recommended Citation
GB/T 7714
Zhang Shuguang,Li Fang,Li Wenya,et al. Expression of Elk-1 in non-small cell lung cancer detected by western blot and tissue microarray[J]. CHINESE JOURNAL OF CANCER RESEARCH,2007,19(1):7-11.
APA Zhang Shuguang,Li Fang,Li Wenya,Lu Wei,&Zhang Lin.(2007).Expression of Elk-1 in non-small cell lung cancer detected by western blot and tissue microarray.CHINESE JOURNAL OF CANCER RESEARCH,19(1),7-11.
MLA Zhang Shuguang,et al."Expression of Elk-1 in non-small cell lung cancer detected by western blot and tissue microarray".CHINESE JOURNAL OF CANCER RESEARCH 19.1(2007):7-11.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Zhang Shuguang]'s Articles
[Li Fang]'s Articles
[Li Wenya]'s Articles
Baidu academic
Similar articles in Baidu academic
[Zhang Shuguang]'s Articles
[Li Fang]'s Articles
[Li Wenya]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Zhang Shuguang]'s Articles
[Li Fang]'s Articles
[Li Wenya]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.