| Expression of Elk-1 in non-small cell lung cancer detected by western blot and tissue microarray | |
| Alternative Title | Expression of Elk-1 in Non-Small Cell Lung Cancer Detected by Western Blot and Tissue Microarray |
| Zhang Shuguang1; Li Fang2; Li Wenya1; Lu Wei1; Zhang Lin1 | |
| 2007 | |
| Source Publication | CHINESE JOURNAL OF CANCER RESEARCH
 |
| ISSN | 1000-9604 |
| Volume | 19Issue:1Pages:7-11 |
| Abstract | Objective: The aim of this study was to investigate the Elk- 1 ( Ets like transcription factor- 1) expression in non- small cell lung cancer ( NSCLC) and normal lung tissues and the relationship between its expression and clinicopathological characters. Methods: To observe Elk- 1 expression, western blot and immunochemistry ( IHC) on tissue microarray ( TMA) containing 118 lung cancers and their corresponding normal tissues were used. Results: In western blot and IHC on TMA, Elk- 1 was highly expressed in NSCLC, while its expression was almost undetectable in normal lung tissues. Elk- 1 expression in NSCLC had no relationship with the patients' age, gender, smoking status and histological type, but had relationship with the differentiation degree, clinical stages and lymphonode metastasis. The expression was lower in early stage group ( I+ II) than in advanced stage group ( III), and lower in well- moderately differentiated group than in poorly differentiated group. The same trend was seen with lymphonode metastasis. Conclusion: The progression of NSCLC may be related with the increased Elk- 1 expression, and Elk- 1 may be regarded as a prognostic factor for NSCLC tissues. |
| Other Abstract | Objective: The aim of this study was to investigate the Elk-1 (Ets like transcription factor-1) expression in non-small cell lung cancer (NSCLC) and normal lung tissues and the relationship between its expression and clinicopathological characters. Methods: To observe Elk-1 expression, western blot and immunochemistry (IHC) on tissue microarray (TMA) containing 118 lung cancers and their corresponding normal tissues were used. Results: In western blot and IHC on TMA, Elk-1 was highly expressed in NSCLC, while its expression was almost undetectable in normal lung tissues. Elk-1 expression in NSCLC had no relationship with the patients' age, gender, smoking status and histological type, but had relationship with the differentiation degree, clinical stages and lymphonode metastasis. The expression was lower in early stage group (I+II) than in advanced stage group (III), and lower in well-moderately differentiated group than in poorly differentiated group. The same trend was seen with lymphonode metastasis. Conclusion: The progression of NSCLC may be related with the increased Elk-1 expression, and Elk-1 may be regarded as a prognostic factor for NSCLC tissues. |
| Keyword | TERNARY COMPLEX FACTORS TRANSCRIPTION FACTORS ETS Elk-1 non-small cell lung cancer western blot immunohistochemistry tissue microarray |
| Indexed By | CSCD |
| Language | 英语 |
| CSCD ID | CSCD:2920359 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/147431 |
| Collection | 中国科学院金属研究所 |
| Affiliation | 1.中国科学院金属研究所 2.Chinese Acad Med Sci, Dept Thorac Surg, Institute Canc, Beijing 100021, Peoples R China Dept Thorac Surg Institute Canc 3.中国医学科学院 4.Peking Union Med Coll, Beijing 100021, Peoples R China |
| Recommended Citation GB/T 7714 | Zhang Shuguang,Li Fang,Li Wenya,et al. Expression of Elk-1 in non-small cell lung cancer detected by western blot and tissue microarray[J]. CHINESE JOURNAL OF CANCER RESEARCH,2007,19(1):7-11. |
| APA | Zhang Shuguang,Li Fang,Li Wenya,Lu Wei,&Zhang Lin.(2007).Expression of Elk-1 in non-small cell lung cancer detected by western blot and tissue microarray.CHINESE JOURNAL OF CANCER RESEARCH,19(1),7-11. |
| MLA | Zhang Shuguang,et al."Expression of Elk-1 in non-small cell lung cancer detected by western blot and tissue microarray".CHINESE JOURNAL OF CANCER RESEARCH 19.1(2007):7-11. |
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