Design, Synthesis and Antiproliferative Activity of Chrysin Derivatives Bearing Triazole Moieties

IMR OpenIR

	Design, Synthesis and Antiproliferative Activity of Chrysin Derivatives Bearing Triazole Moieties
	Luan Tian 1; Quan Zheshan 2; Fang Yingquan 1; Yang Hongjing 1
	2020
Source Publication	CHINESE JOURNAL OF ORGANIC CHEMISTRY
ISSN	0253-2786
Volume	40 Issue:2 Pages:440-446
Abstract	Two series of novel chry sin derivatives were synthesized, and their antiproliferative activity was evaluated against six human cancer cell lines (MGC-803, BEL-7402, HepG2, HeLa, A549, and SGC-7901) using methyl thiazolyl tetrazolium (MTT) assay. Preliminary bioassay results indicated that 7-((1-(3-fluoropheny1)-1H-1,2,3-triazol-4-yl)methoxy)-5-hydroxy-2-phenyl-4H-chromen-4-one (1c) and 7-((1-(2-c hlorophenyl)-1H-1,2,3-triazol-4-yl)methoxy)-5-hydroxy-2-pheny 1-4H-chromen-4-one (1g) exhibited significantly improved antiproliferative activities against the MGC-803 cell line when compared with the parent compound chn'sin and the positive control drug 5-fluorouracil. It demonstrates that compounds lc and lg are potential agents for cancer therapy.
Keyword	INHIBITION CELLS chrysin synthesis triazole derivatives antiproliferation
Indexed By	CSCD
Language	英语
Funding Project	[National Natural Science Foundation of China]
CSCD ID	CSCD:6677895
Citation statistics
Document Type	期刊论文
Identifier	http://ir.imr.ac.cn/handle/321006/147602
Collection	中国科学院金属研究所
Affiliation	1.Chongqing Three Gorges Med Coll, Department Pharm, Chongqing 404120, Peoples R China 2.延边大学 3.中国科学院金属研究所
Recommended Citation GB/T 7714	Luan Tian,Quan Zheshan,Fang Yingquan,et al. Design, Synthesis and Antiproliferative Activity of Chrysin Derivatives Bearing Triazole Moieties[J]. CHINESE JOURNAL OF ORGANIC CHEMISTRY,2020,40(2):440-446.
APA	Luan Tian,Quan Zheshan,Fang Yingquan,&Yang Hongjing.(2020).Design, Synthesis and Antiproliferative Activity of Chrysin Derivatives Bearing Triazole Moieties.CHINESE JOURNAL OF ORGANIC CHEMISTRY,40(2),440-446.
MLA	Luan Tian,et al."Design, Synthesis and Antiproliferative Activity of Chrysin Derivatives Bearing Triazole Moieties".CHINESE JOURNAL OF ORGANIC CHEMISTRY 40.2(2020):440-446.

Files in This Item:
There are no files associated with this item.

If you have any objections to this item, please fill out the form below and the administrator will contact you as soon as possible.
Content:
Email：	*
Institution:
Verification Code:	Refresh

Any comments and suggestions are welcomed.
Title:	*
Content:
Email：	*
Verification Code:	Refresh

中国科学院金属研究所机构知识库