Design, Synthesis and Antiproliferative Activity of Chrysin Derivatives Bearing Triazole Moieties

IMR OpenIR

	Design, Synthesis and Antiproliferative Activity of Chrysin Derivatives Bearing Triazole Moieties
	Luan Tian 1; Quan Zheshan 2; Fang Yingquan 1; Yang Hongjing 1
	2020
发表期刊	CHINESE JOURNAL OF ORGANIC CHEMISTRY
ISSN	0253-2786
卷号	40 期号:2 页码:440-446
摘要	Two series of novel chry sin derivatives were synthesized, and their antiproliferative activity was evaluated against six human cancer cell lines (MGC-803, BEL-7402, HepG2, HeLa, A549, and SGC-7901) using methyl thiazolyl tetrazolium (MTT) assay. Preliminary bioassay results indicated that 7-((1-(3-fluoropheny1)-1H-1,2,3-triazol-4-yl)methoxy)-5-hydroxy-2-phenyl-4H-chromen-4-one (1c) and 7-((1-(2-c hlorophenyl)-1H-1,2,3-triazol-4-yl)methoxy)-5-hydroxy-2-pheny 1-4H-chromen-4-one (1g) exhibited significantly improved antiproliferative activities against the MGC-803 cell line when compared with the parent compound chn'sin and the positive control drug 5-fluorouracil. It demonstrates that compounds lc and lg are potential agents for cancer therapy.
关键词	INHIBITION CELLS chrysin synthesis triazole derivatives antiproliferation
收录类别	CSCD
语种	英语
资助项目	[National Natural Science Foundation of China]
CSCD记录号	CSCD:6677895
引用统计
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/147602
专题	中国科学院金属研究所
作者单位	1.Chongqing Three Gorges Med Coll, Department Pharm, Chongqing 404120, Peoples R China 2.延边大学 3.中国科学院金属研究所
推荐引用方式 GB/T 7714	Luan Tian,Quan Zheshan,Fang Yingquan,et al. Design, Synthesis and Antiproliferative Activity of Chrysin Derivatives Bearing Triazole Moieties[J]. CHINESE JOURNAL OF ORGANIC CHEMISTRY,2020,40(2):440-446.
APA	Luan Tian,Quan Zheshan,Fang Yingquan,&Yang Hongjing.(2020).Design, Synthesis and Antiproliferative Activity of Chrysin Derivatives Bearing Triazole Moieties.CHINESE JOURNAL OF ORGANIC CHEMISTRY,40(2),440-446.
MLA	Luan Tian,et al."Design, Synthesis and Antiproliferative Activity of Chrysin Derivatives Bearing Triazole Moieties".CHINESE JOURNAL OF ORGANIC CHEMISTRY 40.2(2020):440-446.