IMR OpenIR
Design, Synthesis and Antiproliferative Activity of Chrysin Derivatives Bearing Triazole Moieties
Luan Tian1; Quan Zheshan2; Fang Yingquan1; Yang Hongjing1
2020
Source PublicationCHINESE JOURNAL OF ORGANIC CHEMISTRY
ISSN0253-2786
Volume40Issue:2Pages:440-446
AbstractTwo series of novel chry sin derivatives were synthesized, and their antiproliferative activity was evaluated against six human cancer cell lines (MGC-803, BEL-7402, HepG2, HeLa, A549, and SGC-7901) using methyl thiazolyl tetrazolium (MTT) assay. Preliminary bioassay results indicated that 7-((1-(3-fluoropheny1)-1H-1,2,3-triazol-4-yl)methoxy)-5-hydroxy-2-phenyl-4H-chromen-4-one (1c) and 7-((1-(2-c hlorophenyl)-1H-1,2,3-triazol-4-yl)methoxy)-5-hydroxy-2-pheny 1-4H-chromen-4-one (1g) exhibited significantly improved antiproliferative activities against the MGC-803 cell line when compared with the parent compound chn'sin and the positive control drug 5-fluorouracil. It demonstrates that compounds lc and lg are potential agents for cancer therapy.
KeywordINHIBITION CELLS chrysin synthesis triazole derivatives antiproliferation
Indexed ByCSCD
Language英语
Funding Project[National Natural Science Foundation of China]
CSCD IDCSCD:6677895
Citation statistics
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/147602
Collection中国科学院金属研究所
Affiliation1.Chongqing Three Gorges Med Coll, Department Pharm, Chongqing 404120, Peoples R China
2.延边大学
3.中国科学院金属研究所
Recommended Citation
GB/T 7714
Luan Tian,Quan Zheshan,Fang Yingquan,et al. Design, Synthesis and Antiproliferative Activity of Chrysin Derivatives Bearing Triazole Moieties[J]. CHINESE JOURNAL OF ORGANIC CHEMISTRY,2020,40(2):440-446.
APA Luan Tian,Quan Zheshan,Fang Yingquan,&Yang Hongjing.(2020).Design, Synthesis and Antiproliferative Activity of Chrysin Derivatives Bearing Triazole Moieties.CHINESE JOURNAL OF ORGANIC CHEMISTRY,40(2),440-446.
MLA Luan Tian,et al."Design, Synthesis and Antiproliferative Activity of Chrysin Derivatives Bearing Triazole Moieties".CHINESE JOURNAL OF ORGANIC CHEMISTRY 40.2(2020):440-446.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Luan Tian]'s Articles
[Quan Zheshan]'s Articles
[Fang Yingquan]'s Articles
Baidu academic
Similar articles in Baidu academic
[Luan Tian]'s Articles
[Quan Zheshan]'s Articles
[Fang Yingquan]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Luan Tian]'s Articles
[Quan Zheshan]'s Articles
[Fang Yingquan]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.