Design, Synthesis and Antiproliferative Activity of Chrysin Derivatives Bearing Triazole Moieties | |
Luan Tian1; Quan Zheshan2; Fang Yingquan1; Yang Hongjing1 | |
2020 | |
Source Publication | CHINESE JOURNAL OF ORGANIC CHEMISTRY
![]() |
ISSN | 0253-2786 |
Volume | 40Issue:2Pages:440-446 |
Abstract | Two series of novel chry sin derivatives were synthesized, and their antiproliferative activity was evaluated against six human cancer cell lines (MGC-803, BEL-7402, HepG2, HeLa, A549, and SGC-7901) using methyl thiazolyl tetrazolium (MTT) assay. Preliminary bioassay results indicated that 7-((1-(3-fluoropheny1)-1H-1,2,3-triazol-4-yl)methoxy)-5-hydroxy-2-phenyl-4H-chromen-4-one (1c) and 7-((1-(2-c hlorophenyl)-1H-1,2,3-triazol-4-yl)methoxy)-5-hydroxy-2-pheny 1-4H-chromen-4-one (1g) exhibited significantly improved antiproliferative activities against the MGC-803 cell line when compared with the parent compound chn'sin and the positive control drug 5-fluorouracil. It demonstrates that compounds lc and lg are potential agents for cancer therapy. |
Keyword | INHIBITION CELLS chrysin synthesis triazole derivatives antiproliferation |
Indexed By | CSCD |
Language | 英语 |
Funding Project | [National Natural Science Foundation of China] |
CSCD ID | CSCD:6677895 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.imr.ac.cn/handle/321006/147602 |
Collection | 中国科学院金属研究所 |
Affiliation | 1.Chongqing Three Gorges Med Coll, Department Pharm, Chongqing 404120, Peoples R China 2.延边大学 3.中国科学院金属研究所 |
Recommended Citation GB/T 7714 | Luan Tian,Quan Zheshan,Fang Yingquan,et al. Design, Synthesis and Antiproliferative Activity of Chrysin Derivatives Bearing Triazole Moieties[J]. CHINESE JOURNAL OF ORGANIC CHEMISTRY,2020,40(2):440-446. |
APA | Luan Tian,Quan Zheshan,Fang Yingquan,&Yang Hongjing.(2020).Design, Synthesis and Antiproliferative Activity of Chrysin Derivatives Bearing Triazole Moieties.CHINESE JOURNAL OF ORGANIC CHEMISTRY,40(2),440-446. |
MLA | Luan Tian,et al."Design, Synthesis and Antiproliferative Activity of Chrysin Derivatives Bearing Triazole Moieties".CHINESE JOURNAL OF ORGANIC CHEMISTRY 40.2(2020):440-446. |
Files in This Item: | There are no files associated with this item. |
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment