| Design, synthesis and biological evaluation of novel glucokinase activators | |
| Alternative Title | Design, synthesis and biological evaluation of novel glucokinase activators |
| Li Yong Qiang1; Zhang Yu Liang3; Hu Sheng Quan3; Wang Yu Ling3; Song Hong Rui3; Feng Zhi Qiang1; Lei Lei1; Liu Quan1; Shen Zhu Fang1 | |
| 2011 | |
| Source Publication | CHINESE CHEMICAL LETTERS
 |
| ISSN | 1001-8417 |
| Volume | 22Issue:1Pages:73-76 |
| Abstract | A new series of benzamide derivatives as glucokinase activators (GKAs) were designed and synthesized, and their activation for glucokinase were evaluated by the preliminary glucokinase activity assay. The structure activity relationship (SAR) is discussed. The result shows that compound 12d and 12h have potent activity reference drug RO-28-1675. (C) 2010 Zhi Qiang Feng. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved. |
| Other Abstract | A new series of benzamide derivatives as glucokinase activators (GKAs) were designed and synthesized, and their activation for glucokinase were evaluated by the preliminary glucokinase activity assay. The structure-activity relationship (SAR) is discussed. The result shows that compound 12d and 12h have potent activity reference drug RO-28-1675 |
| Keyword | DISCOVERY POTENT Diabetes Glucokinase activators Benzamide derivatives |
| Indexed By | CSCD |
| Language | 英语 |
| Funding Project | [National Nature Science Foundation of China] |
| CSCD ID | CSCD:4122342 |
| Citation statistics |
Cited Times:1[CSCD]
[CSCD Record]
|
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/148338 |
| Collection | 中国科学院金属研究所 |
| Affiliation | 1.Chinese Acad Med Sci, Institute Mat Med, Beijing 100050, Peoples R China Institute Mat Med 2.Peking Union Med Coll, Beijing 100050, Peoples R China 3.中国科学院金属研究所 |
| Recommended Citation GB/T 7714 | Li Yong Qiang,Zhang Yu Liang,Hu Sheng Quan,et al. Design, synthesis and biological evaluation of novel glucokinase activators[J]. CHINESE CHEMICAL LETTERS,2011,22(1):73-76. |
| APA | Li Yong Qiang.,Zhang Yu Liang.,Hu Sheng Quan.,Wang Yu Ling.,Song Hong Rui.,...&Shen Zhu Fang.(2011).Design, synthesis and biological evaluation of novel glucokinase activators.CHINESE CHEMICAL LETTERS,22(1),73-76. |
| MLA | Li Yong Qiang,et al."Design, synthesis and biological evaluation of novel glucokinase activators".CHINESE CHEMICAL LETTERS 22.1(2011):73-76. |
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