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Conversion Conditions and Influence Factors of Nitrendipine Crystal Polymorphism
Alternative TitleConversion Conditions and Influence Factors of Nitrendipine Crystal Polymorphism
Yuan HengJie1; Chen DaWei3; Ren Yun1; Lou JianShi2
2008
Source PublicationACTA CHIMICA SINICA
ISSN0567-7351
Volume66Issue:21Pages:2429-2433
AbstractTheoretical conversion temperature was calculated between different crystal forms of nitrendipine from melting data. The different conversion conditions were investigated, such as high temperature, high temperature and humidity and high pressure. The theoretical conversion temperature between nitrendipine I and II is 158.88 degrees C, that between nitrendipine I and III is 160.50 degrees C and that between nitrendipine II and III is 159.65 degrees C, indicating nitrendipine polymorphs belong to a monotropic system. At high temperature, nitrendipine II and III both converted to I. Under high pressure, II converted to I. The results indicate that nitrendipine I was a stable form, while II and III were metastable form. The stability ranked as I>II>III. Keywords nitrendipine; crystal polymorph; conversion; X-ray diffraction
Keywordnitrendipine crystal polymorph conversion X-ray diffraction
Indexed ByCSCD
Language英语
CSCD IDCSCD:3459506
Citation statistics
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/148538
Collection中国科学院金属研究所
Affiliation1.Tianjin Med University, Gen Hosp, Dept Pharm, Tianjin 300052, Peoples R China
2.安徽肥东花生原种场
3.中国科学院金属研究所
Recommended Citation
GB/T 7714
Yuan HengJie,Chen DaWei,Ren Yun,et al. Conversion Conditions and Influence Factors of Nitrendipine Crystal Polymorphism[J]. ACTA CHIMICA SINICA,2008,66(21):2429-2433.
APA Yuan HengJie,Chen DaWei,Ren Yun,&Lou JianShi.(2008).Conversion Conditions and Influence Factors of Nitrendipine Crystal Polymorphism.ACTA CHIMICA SINICA,66(21),2429-2433.
MLA Yuan HengJie,et al."Conversion Conditions and Influence Factors of Nitrendipine Crystal Polymorphism".ACTA CHIMICA SINICA 66.21(2008):2429-2433.
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