Synthesis, Crystal Structure and Antiproliferative Activity of Ethyl 1-(Phenylcarbamoyl)-2-3,4,5-trimethoxyphenyl)cyclopropanecarboxylae

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	Synthesis, Crystal Structure and Antiproliferative Activity of Ethyl 1-(Phenylcarbamoyl)-2-3,4,5-trimethoxyphenyl)cyclopropanecarboxylae
其他题名	Synthesis, Crystal Structure and Antiproliferative Activity of Ethyl 1-(Phenylcarbamoyl)-2-3,4,5-trimethoxyphenyl)cyclopropanecarboxylae
	Zhang JingYi; Zhong HanYu; Shi GuoBing
	2014
发表期刊	CHINESE JOURNAL OF STRUCTURAL CHEMISTRY
ISSN	0254-5861
卷号	33 期号:6 页码:876-880
摘要	Many small-molecule compounds have been evaluated with potential antiproliferative activities. Ethyl 1-(phenylcarbamoyl)-2-(3,4,5-trimethoxyphenyl)cyclopropanecarboxylate, one novel cyclopropylamide analogue of combretastatin-A4 (CA-4), has been synthesized and its crystal structure was characterized by X-ray single-crystal diffraction. The crystal belongs to monoclinic, space group P2(1)/n, with a = 15.0263(3), b = 7.6574(2), c = 19.4117(4) angstrom, beta = 111.9010(10), V= 2072.36(8) angstrom(3), Z = 4, C22H24NO6, M-r = 398.42, D-c, = 1.277 Mg/cm(3), F(000) = 844, lambda(MoK alpha) = 1.54178 angstrom, mu = 0.770 mm(-1), R= 0.0546 and wR = 0.1889 for 3319 observed -reflections (I> 2 sigma(I)). Meanwhile, the compound revealed potential antiproliferative activities in several cancer cells in vitro.
其他摘要	Many small-molecule compounds have been evaluated with potential antiproliferative activities. Ethyl 1-(phenylcarbamoyl)-2-(3,4,5-trimethoxyphenyl)cyclopropanecarboxylate, one novel cyclopropylamide analogue of combretastatin-A4 (CA-4), has been synthesized and its crystal structure was characterized by X-ray single-crystal diffraction. The crystal belongs to monoclinic, space group P2_1/n, with a = 15.0263(3), b = 7.6574(2), c = 19.4117(4) A, β = 111.9010(10)°, V = 2072.36(8) A~3, Z = 4, C_(22)H_(24)NO_6, Mr = 398.42, D_c = 1.277 Mg/cm~3, F(000) = 844, A(MoKa) = 1.54178 A, μ = 0.770 mm~(-1), R = 0.0546 and wR = 0.1889 for 3319 observed reflections (I > 2σ(I)). Meanwhile, the compound revealed potential antiproliferative activities- in several cancer cells in vitro.
关键词	ANTITUMOR-ACTIVITY DERIVATIVES 3,4,5-trimethoxyphenyl synthesis crystal structure antiproliferative activities
收录类别	CSCD
语种	英语
CSCD记录号	CSCD:5169669
引用统计
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/148812
专题	中国科学院金属研究所
作者单位	中国科学院金属研究所
推荐引用方式 GB/T 7714	Zhang JingYi,Zhong HanYu,Shi GuoBing. Synthesis, Crystal Structure and Antiproliferative Activity of Ethyl 1-(Phenylcarbamoyl)-2-3,4,5-trimethoxyphenyl)cyclopropanecarboxylae[J]. CHINESE JOURNAL OF STRUCTURAL CHEMISTRY,2014,33(6):876-880.
APA	Zhang JingYi,Zhong HanYu,&Shi GuoBing.(2014).Synthesis, Crystal Structure and Antiproliferative Activity of Ethyl 1-(Phenylcarbamoyl)-2-3,4,5-trimethoxyphenyl)cyclopropanecarboxylae.CHINESE JOURNAL OF STRUCTURAL CHEMISTRY,33(6),876-880.
MLA	Zhang JingYi,et al."Synthesis, Crystal Structure and Antiproliferative Activity of Ethyl 1-(Phenylcarbamoyl)-2-3,4,5-trimethoxyphenyl)cyclopropanecarboxylae".CHINESE JOURNAL OF STRUCTURAL CHEMISTRY 33.6(2014):876-880.