Fluoxetine inhibited extracellular matrix of pulmonary artery and inflammation of lungs in monocrotaline-treated rats

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	Fluoxetine inhibited extracellular matrix of pulmonary artery and inflammation of lungs in monocrotaline-treated rats
其他题名	Fluoxetine inhibited extracellular matrix of pulmonary artery and inflammation of lungs in monocrotaline-treated rats
	Li Xueqin 1; Wang Hanming 1; Yang Chunguang 1; Zhang Xinhua 1; Han Dandan 1; Wang Huailiang 1
	2011
发表期刊	ACTA PHARMACOLOGICA SINICA
ISSN	1671-4083
卷号	32 期号:2 页码:217-222
摘要	Aim: To investigate the effects of the selective serotonin reuptake inhibitor (SSRI) fluoxetine on extracellular matrix (ECM) remodeling of the pulmonary artery and inflammation of the lungs in pulmonary arterial hypertension (PAH) induced by monocrotaline in rats.
其他摘要	Aim: To investigate the effects of the selective serotonin reuptake inhibitor (SSRI) fluoxetine on extracellular matrix (ECM) remodeling of the pulmonary artery and inflammation of the lungs in pulmonary arterial hypertension (PAH) induced by monocrotaline in rats. Methods: MCT-induced chronic PAH was established in Wistar rats. After treatment with fluoxetine for 3 weeks, pulmonary hemodynamic measurement and morphological investigation of lung tissues were undertaken. The main components of the ECM, elastin and collagen, were detected using Van Gieson stain and Orcein stain, respectively, or using Victoria-ponceau's double stain. The ECM proteolytic enzymes matrix metalloproteinase (MMP)-2 and MMP-9, and the tissue inhibitors of metalloproteinase (TIMP)-1 and TIMP-2, were detected by Western blot. Inflammation of lung tissue was assayed using lung morphology and inflammatory cytokine expression. Results: Fluoxetine (2 and 10 mg Conclusion: Fluoxetine inhibited MCT-induced ECM remodeling of the pulmonary artery and inflammation of lung tissue. These effects were related to its inhibition on MMPs
关键词	SMOOTH-MUSCLE-CELLS SEROTONIN TRANSPORTER HYPERTENSION METALLOPROTEINASES COLLAGENASE EXPRESSION PROTECTS extracellular matrix inflammation pulmonary arterial hypertension selective serotonin reuptake inhibitor
收录类别	CSCD
语种	英语
资助项目	[National Natural Science Foundation of China]
CSCD记录号	CSCD:4124334
引用统计	被引频次：3[CSCD] [CSCD记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/148872
专题	中国科学院金属研究所
作者单位	1.中国科学院金属研究所 2.Zhongshan City Peoples Hosp, Department Pharm, Zhongshan 528403, Peoples R China
推荐引用方式 GB/T 7714	Li Xueqin,Wang Hanming,Yang Chunguang,et al. Fluoxetine inhibited extracellular matrix of pulmonary artery and inflammation of lungs in monocrotaline-treated rats[J]. ACTA PHARMACOLOGICA SINICA,2011,32(2):217-222.
APA	Li Xueqin,Wang Hanming,Yang Chunguang,Zhang Xinhua,Han Dandan,&Wang Huailiang.(2011).Fluoxetine inhibited extracellular matrix of pulmonary artery and inflammation of lungs in monocrotaline-treated rats.ACTA PHARMACOLOGICA SINICA,32(2),217-222.
MLA	Li Xueqin,et al."Fluoxetine inhibited extracellular matrix of pulmonary artery and inflammation of lungs in monocrotaline-treated rats".ACTA PHARMACOLOGICA SINICA 32.2(2011):217-222.