| Synthesis and in vitro cytotoxicity of novel 1,4-disubstituted phthalazines | |
| Alternative Title | Synthesis and in vitro cytotoxicity of novel 1,4-disubstituted phthalazines |
| Zhai Xin; Li Juan; He Lei; Zheng Su; Bin Zhang Yao; Gong Ping | |
| 2008 | |
| Source Publication | CHINESE CHEMICAL LETTERS
 |
| ISSN | 1001-8417 |
| Volume | 19Issue:1Pages:29-32 |
| Abstract | Eight novel 1,4-disubstituted phthalazines (7-14) were designed and synthesized. The structures of all the synthesized compounds were confirmed by IR, H-1 NMR, C-13 NMR, MS and elemental analysis. Their in vitro cytotoxicity against cancer cell lines (Bel-7402 and HT-1080) were evaluated by standard MTT assay. Among them, compounds 9 and 11 exhibited more potent cytotoxicity than cisplatin. (C) 2007 Ping Gong. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved. |
| Other Abstract | Eight novel 1,4-disubstituted phthalazines (7-14) were designed and synthesized. The structures of all the synthesizedcompounds were confirmed by IR, 1H NMR,13C NMR, MS and elemental analysis. Their in vitro cytotoxicity against cancercell lines (Bel-7402 and HT-1080) were evaluated by standard MTT assay. Among them, compounds 9 and 11 exhibited more potentcytotoxicity than cisplatin. |
| Keyword | 6-METHOXY-1,4-DISUBSTITUTED DERIVATIVES INHIBITORS phthalazine derivatives synthesis cytotoxicity |
| Indexed By | CSCD |
| Language | 英语 |
| CSCD ID | CSCD:3316587 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/149139 |
| Collection | 中国科学院金属研究所 |
| Affiliation | 中国科学院金属研究所 |
| Recommended Citation GB/T 7714 | Zhai Xin,Li Juan,He Lei,et al. Synthesis and in vitro cytotoxicity of novel 1,4-disubstituted phthalazines[J]. CHINESE CHEMICAL LETTERS,2008,19(1):29-32. |
| APA | Zhai Xin,Li Juan,He Lei,Zheng Su,Bin Zhang Yao,&Gong Ping.(2008).Synthesis and in vitro cytotoxicity of novel 1,4-disubstituted phthalazines.CHINESE CHEMICAL LETTERS,19(1),29-32. |
| MLA | Zhai Xin,et al."Synthesis and in vitro cytotoxicity of novel 1,4-disubstituted phthalazines".CHINESE CHEMICAL LETTERS 19.1(2008):29-32. |
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