| Synthesis and in vitro cytotoxicity of novel 1,4-disubstituted phthalazines |
| 其他题名 | Synthesis and in vitro cytotoxicity of novel 1,4-disubstituted phthalazines
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| Zhai Xin; Li Juan; He Lei; Zheng Su; Bin Zhang Yao; Gong Ping
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| 2008
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| 发表期刊 | CHINESE CHEMICAL LETTERS
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| ISSN | 1001-8417
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| 卷号 | 19期号:1页码:29-32 |
| 摘要 | Eight novel 1,4-disubstituted phthalazines (7-14) were designed and synthesized. The structures of all the synthesized compounds were confirmed by IR, H-1 NMR, C-13 NMR, MS and elemental analysis. Their in vitro cytotoxicity against cancer cell lines (Bel-7402 and HT-1080) were evaluated by standard MTT assay. Among them, compounds 9 and 11 exhibited more potent cytotoxicity than cisplatin. (C) 2007 Ping Gong. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved. |
| 其他摘要 | Eight novel 1,4-disubstituted phthalazines (7-14) were designed and synthesized. The structures of all the synthesizedcompounds were confirmed by IR, 1H NMR,13C NMR, MS and elemental analysis. Their in vitro cytotoxicity against cancercell lines (Bel-7402 and HT-1080) were evaluated by standard MTT assay. Among them, compounds 9 and 11 exhibited more potentcytotoxicity than cisplatin. |
| 关键词 | 6-METHOXY-1,4-DISUBSTITUTED DERIVATIVES
INHIBITORS
phthalazine derivatives
synthesis
cytotoxicity
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| 收录类别 | CSCD
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| 语种 | 英语
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| CSCD记录号 | CSCD:3316587
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| 引用统计 |
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| 文献类型 | 期刊论文
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| 条目标识符 | http://ir.imr.ac.cn/handle/321006/149139
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| 专题 | 中国科学院金属研究所
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| 作者单位 | 中国科学院金属研究所
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推荐引用方式
GB/T 7714 |
Zhai Xin,Li Juan,He Lei,et al. Synthesis and in vitro cytotoxicity of novel 1,4-disubstituted phthalazines[J]. CHINESE CHEMICAL LETTERS,2008,19(1):29-32.
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| APA |
Zhai Xin,Li Juan,He Lei,Zheng Su,Bin Zhang Yao,&Gong Ping.(2008).Synthesis and in vitro cytotoxicity of novel 1,4-disubstituted phthalazines.CHINESE CHEMICAL LETTERS,19(1),29-32.
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| MLA |
Zhai Xin,et al."Synthesis and in vitro cytotoxicity of novel 1,4-disubstituted phthalazines".CHINESE CHEMICAL LETTERS 19.1(2008):29-32.
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