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Synthesis and in vitro cytotoxicity of novel 1,4-disubstituted phthalazines
Alternative TitleSynthesis and in vitro cytotoxicity of novel 1,4-disubstituted phthalazines
Zhai Xin; Li Juan; He Lei; Zheng Su; Bin Zhang Yao; Gong Ping
2008
Source PublicationCHINESE CHEMICAL LETTERS
ISSN1001-8417
Volume19Issue:1Pages:29-32
AbstractEight novel 1,4-disubstituted phthalazines (7-14) were designed and synthesized. The structures of all the synthesized compounds were confirmed by IR, H-1 NMR, C-13 NMR, MS and elemental analysis. Their in vitro cytotoxicity against cancer cell lines (Bel-7402 and HT-1080) were evaluated by standard MTT assay. Among them, compounds 9 and 11 exhibited more potent cytotoxicity than cisplatin. (C) 2007 Ping Gong. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
Other AbstractEight novel 1,4-disubstituted phthalazines (7-14) were designed and synthesized. The structures of all the synthesizedcompounds were confirmed by IR, 1H NMR,13C NMR, MS and elemental analysis. Their in vitro cytotoxicity against cancercell lines (Bel-7402 and HT-1080) were evaluated by standard MTT assay. Among them, compounds 9 and 11 exhibited more potentcytotoxicity than cisplatin.
Keyword6-METHOXY-1,4-DISUBSTITUTED DERIVATIVES INHIBITORS phthalazine derivatives synthesis cytotoxicity
Indexed ByCSCD
Language英语
CSCD IDCSCD:3316587
Citation statistics
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/149142
Collection中国科学院金属研究所
Affiliation中国科学院金属研究所
Recommended Citation
GB/T 7714
Zhai Xin,Li Juan,He Lei,et al. Synthesis and in vitro cytotoxicity of novel 1,4-disubstituted phthalazines[J]. CHINESE CHEMICAL LETTERS,2008,19(1):29-32.
APA Zhai Xin,Li Juan,He Lei,Zheng Su,Bin Zhang Yao,&Gong Ping.(2008).Synthesis and in vitro cytotoxicity of novel 1,4-disubstituted phthalazines.CHINESE CHEMICAL LETTERS,19(1),29-32.
MLA Zhai Xin,et al."Synthesis and in vitro cytotoxicity of novel 1,4-disubstituted phthalazines".CHINESE CHEMICAL LETTERS 19.1(2008):29-32.
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