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A non-opioid pathway for dynorphin-caused spinal cord injury in rats
Alternative TitleA non-opioid pathway for dynorphin-caused spinal cord injury in rats ☆
Chen Yu; Xiang Liangbi; Liu Jun; Zhou Dapeng; Yu Hailong; Wang Qi; Han Wenfeng; Guo Mingming
2012
Source PublicationNEURAL REGENERATION RESEARCH
ISSN1673-5374
Volume7Issue:11Pages:815-820
AbstractIntrathecal injection of dynorphin into rats via subarachnoid catheter induces damage to spinal cord tissue and motor function. Injection of the kappa opioid receptor antagonist nor-binaltorphine, or the excitatory amino acid N-methyl-D-aspartate receptor antagonist MK-801 into rats alleviated the pathological changes of dynorphin-caused spinal cord tissue injury and reduced the acid phosphatase activity in the spinal cord. The experimental findings indicate that there are opioid and non-opioid pathways for dynorphin-induced spinal cord injury, and that the non-opioid receptor pathway may be mediated by the excitatory amino acid N-methyl-D-aspartate receptor.
Other AbstractIntrathecal injection of dynorphin into rats via subarachnoid catheter induces damage to spinal cord tissue and motor function. Injection of the kappa opioid receptor antagonist nor-binaltorphine, or the excitatory amino acid N-methyl-D-aspartate receptor antagonist MK-801 into rats alleviated the pathological changes of dynorphin-caused spinal cord tissue injury and reduced the acid phosphatase activity in the spinal cord. The experimental findings indicate that there are opioid and non-opioid pathways for dynorphin-induced spinal cord injury, and that the non-opioid receptor pathway may be mediated by the excitatory amino acid N-methyl-D-aspartate receptor.
KeywordPROSTATIC ACID-PHOSPHATASE RECEPTOR ANTAGONIST PAIN SENSITIZATION NEURONS MK-801 NMDA INHIBITION TRAUMA spinal cord injury dynorphin kappa opioid receptor antagonist N-methyl-D-aspartate receptor antagonist motor function acid phosphatase
Indexed ByCSCD
Language英语
Funding Project[Science and Key Technology Research and Development Program of Liaoning Province]
CSCD IDCSCD:4530874
Citation statistics
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/149389
Collection中国科学院金属研究所
Affiliation中国科学院金属研究所
Recommended Citation
GB/T 7714
Chen Yu,Xiang Liangbi,Liu Jun,et al. A non-opioid pathway for dynorphin-caused spinal cord injury in rats[J]. NEURAL REGENERATION RESEARCH,2012,7(11):815-820.
APA Chen Yu.,Xiang Liangbi.,Liu Jun.,Zhou Dapeng.,Yu Hailong.,...&Guo Mingming.(2012).A non-opioid pathway for dynorphin-caused spinal cord injury in rats.NEURAL REGENERATION RESEARCH,7(11),815-820.
MLA Chen Yu,et al."A non-opioid pathway for dynorphin-caused spinal cord injury in rats".NEURAL REGENERATION RESEARCH 7.11(2012):815-820.
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