IMR OpenIR
Transplantation of placenta-derived mesenchymal stem cell-induced neural stem cells to treat spinal cord injury
Alternative TitleTransplantation of placenta-derived mesenchymal stem cell-induced neural stem cells to treat spinal cord injury
Li Zhi1; Zhao Wei1; Liu Wei1; Zhou Ye1; Jia Jingqiao2; Yang Lifeng1
2014
Source PublicationNEURAL REGENERATION RESEARCH
ISSN1673-5374
Volume9Issue:24Pages:2197-2204
AbstractBecause of their strong proliferative capacity and multi-potency, placenta-derived mesenchymal stem cells have gained interest as a cell source in the field of nerve damage repair. In the present study, human placenta-derived mesenchymal stem cells were induced to differentiate into neural stem cells, which were then transplanted into the spinal cord after local spinal cord injury in rats. The motor functional recovery and pathological changes in the injured spinal cord were observed for 3 successive weeks. The results showed that human placenta-derived mesenchymal stem cells can differentiate into neuron-like cells and that induced neural stem cells contribute to the restoration of injured spinal cord without causing transplant rejection. Thus, these cells promote the recovery of motor and sensory functions in a rat model of spinal cord injury. Therefore, human placenta-derived mesenchymal stem cells may be useful as seed cells during the repair of spinal cord injury.
Other AbstractBecause of their strong proliferative capacity and multi-potency, placenta-derived mesenchymal stem cells have gained interest as a cell source in the field of nerve damage repair. In the present study, human placenta-derived mesenchymal stem cells were induced to differentiate into neural stem cells, which were then transplanted into the spinal cord after local spinal cord injury in rats. The motor functional recovery and pathological changes in the injured spinal cord were observed for 3 successive weeks. The results showed that human placenta-derived mesenchymal stem cells can differentiate into neuron-like cells and that induced neural stem cells contribute to the restoration of injured spinal cord without causing transplant rejection. Thus, these cells promote the recovery of motor and sensory functions in a rat model of spinal cord injury. Therefore, human placenta-derived mesenchymal stem cells may be useful as seed cells during the repair of spinal cord injury.
KeywordAMNIOTIC MEMBRANE REPAIR nerve regeneration stem cells placenta-derived mesenchymal stem cells spinal cord injury neural stem cells nerve-like cells motor function sensory function neural regeneration
Indexed ByCSCD
Language英语
Funding Project[Scientific Research Program of Liaoning Provincial Science and Technology Ministry in China]
CSCD IDCSCD:5325092
Citation statistics
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/149604
Collection中国科学院金属研究所
Affiliation1.中国科学院金属研究所
2.Liaoning Prov Wellcare Stem Cells Biotechnology Co L, Benxi, Liaoning, Peoples R China
Recommended Citation
GB/T 7714
Li Zhi,Zhao Wei,Liu Wei,et al. Transplantation of placenta-derived mesenchymal stem cell-induced neural stem cells to treat spinal cord injury[J]. NEURAL REGENERATION RESEARCH,2014,9(24):2197-2204.
APA Li Zhi,Zhao Wei,Liu Wei,Zhou Ye,Jia Jingqiao,&Yang Lifeng.(2014).Transplantation of placenta-derived mesenchymal stem cell-induced neural stem cells to treat spinal cord injury.NEURAL REGENERATION RESEARCH,9(24),2197-2204.
MLA Li Zhi,et al."Transplantation of placenta-derived mesenchymal stem cell-induced neural stem cells to treat spinal cord injury".NEURAL REGENERATION RESEARCH 9.24(2014):2197-2204.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Li Zhi]'s Articles
[Zhao Wei]'s Articles
[Liu Wei]'s Articles
Baidu academic
Similar articles in Baidu academic
[Li Zhi]'s Articles
[Zhao Wei]'s Articles
[Liu Wei]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Li Zhi]'s Articles
[Zhao Wei]'s Articles
[Liu Wei]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.