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Synthesis, Structures, and Helicobacter Pylori Urease Inhibition of Oxovanadium(V) Complexes with Hydrazones
Alternative TitleSynthesis,Structures,and Helicobacter Pylori Urease Inhibition of Oxovanadium(V) Complexes with Hydrazones
Zhao Yue1; Han Xiao2; Zhou XiaoXia1; Li HaiHua1; You ZhongLu1
2013
Source PublicationCHINESE JOURNAL OF INORGANIC CHEMISTRY
ISSN1001-4861
Volume29Issue:4Pages:867-874
AbstractIn order to explore new and efficient urease inhibitors, two new oxovanadium (V) complexes, VOL1 (OCH3)(CH3OH) (1) and VOL2(mu-OCH3)(2) (2) (H2L1=N'-(5-chloro-2-hydroxybenzylidene)-3-nitrobenzohydrazide; H2L2=N'-(5-chloro-2-hydroxybenzylidene)-4-chlorobenzohydrazide), have been synthesized and characterized by physico-chemical methods and single-crystal X-ray diffraction. Compound 1 is a mononuclear complex, and compound 2 is a bis-methanolato bridged centrosymmetric dinuclear complex. The V atom in each complex adopts an octahedral coordination. Thermal stability and urease inhibitory activities of the complexes were studied. The percent inhibition at the concentration of 100 mu mol . L-1 on Helicobacter pylori urease is 71.4% for 1 and 73.3% for 2. The IC50 values for 1 and 2 are 63.6 and 37.7 mu mol . L-1, respectively. CCDC: 858857, 1; and 858858, 2.
Other AbstractIn order to explore new and efficient urease inhibitors, two new oxovanadium(Ⅴ)complexes, VOL~1 (OCH_3)(CH_3OH) (1) and VOL~2 (μ-OCH_3)_2 (2) (H_2L~1=N′-(5-chloro-2-hydroxybenzylidene)-3-nitrobenzohydrazide; H_2L~2=N′-(5-chloro-2-hydroxybenzylidene)-4-chlorobenzohydrazide), have been synthesized and characterized by physico-chemical methods and single-crystal X-ray diffraction. Compound 1 is a mononuclear complex, and compound 2 is a bis-methanolato bridged centrosymmetric dinuclear complex. The V atom in each complex adopts an octahedral coordination. Thermal stability and urease inhibitory activities of the complexes were studied. The percent inhibition at the concentration of 100 μmol·L~(-1) on Helicobacter pylori urease is 71.4% for 1 and 73.3% for 2. The IC_(50) values for 1 and 2 are 63.6 and 37.7 μmol·L~(-1), respectively.
KeywordCRYSTAL-STRUCTURE COORDINATION CHEMISTRY METAL-COMPLEXES IN-VITRO LIGANDS DERIVATIVES CHELATORS AMMONIA SOIL hydrazone oxovanadium(V) complex crystal structure urease inhibitor
Indexed ByCSCD
Language英语
CSCD IDCSCD:4833328
Citation statistics
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/149826
Collection中国科学院金属研究所
Affiliation1.辽宁师范大学
2.中国科学院金属研究所
Recommended Citation
GB/T 7714
Zhao Yue,Han Xiao,Zhou XiaoXia,et al. Synthesis, Structures, and Helicobacter Pylori Urease Inhibition of Oxovanadium(V) Complexes with Hydrazones[J]. CHINESE JOURNAL OF INORGANIC CHEMISTRY,2013,29(4):867-874.
APA Zhao Yue,Han Xiao,Zhou XiaoXia,Li HaiHua,&You ZhongLu.(2013).Synthesis, Structures, and Helicobacter Pylori Urease Inhibition of Oxovanadium(V) Complexes with Hydrazones.CHINESE JOURNAL OF INORGANIC CHEMISTRY,29(4),867-874.
MLA Zhao Yue,et al."Synthesis, Structures, and Helicobacter Pylori Urease Inhibition of Oxovanadium(V) Complexes with Hydrazones".CHINESE JOURNAL OF INORGANIC CHEMISTRY 29.4(2013):867-874.
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