Alternative TitleDegradation of Mg-1.5Sr alloy during bone repair in rats
王梁1; 张睿1; 彭远来1; 马新硕1; 危紫翼1; 姚杰1; 高浩源1; 张英泽2; 谭丽丽3; 郑诚功1
Source Publication中华创伤骨科杂志
Other AbstractObjective To explore the effect of degrading process of Mg-Sr alloy (containing 1.5 wt% Sr) on bone growth in rats. Methods Twelve male SD rats of 8 weeks old were randomly divided into 2 even groups ( n = 6). In the experimental group, a stent made of Mg-1.5Sr alloy was put into the left femoral condyle of each rat while a pure Mg stand was used in the control group. The 2 groups were subjected to Micro-CT scanning at 4, 8, and 12 weeks after surgery. Cross-sectional images were generated for clear observation of the degrading process of the stands and the skeletal growth in the rats. Next, 3D models were made to compare changes in stand volume to calculate their degrading rates. The skeletal growth in the rats were also analyzed by measuring a series of indexes, including bone mineral density (BMD), bone volume fraction (BV/TV), trabeeular thickness (Tb. Th) and trabeeular number (Tb. N. ). Results The cross-sectional images at 4, 8 and 12 weeks showed that the Mg-1.5Sr stands degraded more slowly than the pure Mg ones and more new bone grew out around the Mg-1.5St stands than around the pure Mg ones. The degrading rates of Mg-1.5Sr alloy inside the rats at 4, 8 and 12 weeks were respectively 0.34 ±0.04 ram/y, 0. 28 ± 0. 09 mm/y and 0. 31 ± 0.05 ram/y, significantly lower than those of pure Mg (0. 51 ± 0. 01 ram/y, 0. 37 ± 0. 08 mm/y and 0. 39 ± 0. 06 mm/y) (P 〈0.05). The BMD, BV/TV, Tb. ThandTb. Nat12 weeks in the experimental group (0. 62 ±0.08 g/mm^3, 53% ± 11%, 298 ±50 μm, 0. 0027 ±0. 0002/μm) were significantly greater than those in the control group (0.56 ± 0.08 g/mm^3, 48% ± 8%, 220 ± 40 μm, 0. 0023 ± 0. 0002/μm) ( P 〈 0. 05 ). Conehmion Mg-1.5Sr alloy may be a promising orthopedic im- plant material with great bioeompatibility due to its relatively low degrading rate and good bone formation performance.
Keyword 合金 降解 骨修复
Indexed ByCSCD
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GB/T 7714
王梁,张睿,彭远来,等. Mg-1.5Sr合金在大鼠骨修复过程中降解的实验研究[J]. 中华创伤骨科杂志,2016,18.0(011):988-993.
APA 王梁.,张睿.,彭远来.,马新硕.,危紫翼.,...&郑诚功.(2016).Mg-1.5Sr合金在大鼠骨修复过程中降解的实验研究.中华创伤骨科杂志,18.0(011),988-993.
MLA 王梁,et al."Mg-1.5Sr合金在大鼠骨修复过程中降解的实验研究".中华创伤骨科杂志 18.0.011(2016):988-993.
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