IMR OpenIR
Expressions of Livin and Smac proteins in non-small cell lung cancer
Alternative TitleExpressions of Livin and Smac proteins in non-small cell lung cancer
Yang Chunlu1; Chen Xiao1; Zhao Jun1; Lan Xingang1; Xu Sun1; Zhang Huan2; Han Libo1; Zhang Lin1
2008
Source PublicationCHINESE JOURNAL OF CANCER RESEARCH
ISSN1000-9604
Volume20Issue:2Pages:144-149
AbstractObjective: To investigate the expression characteristics of Livin and second mitochondrial activator of Caspase (Smac) proteins in non-small cell lung cancer (NSCLC), and analyze their effect on patients' prognosis. Methods: The expressions of Livin and Smac proteins were detected in 89 NSCLC tissue samples and 25 normal lung tissue samples by immunohistochemical technique. Results: The positive expression rates of Livin and Smac proteins in NSCLC tissues were 53.9%, and 58.4% respectively, higher than that in normal lung tissues (P 0.05). The expression level of Smac protein was closely related to lymph node metastasis, TNM stage (P 0.05). Kaplan-Meier analysis revealed a significant impact on survival by Livin protein in NSCLC (P 0.05). Conclusions: Overexpression of Livin protein may play a promoting role in the occurrence and progression of NSCLC. Moreover, it may bring an adverse effect on patients' prognosis. Although overexpression of Smac protein affects the occurrence and progression of NSCLC, it has no relationship with the prognosis. Livin protein may be helpful to evaluate the progression of NSCLC, and to predict the prognosis.
Other AbstractObjective:To investigate the expression characteristics of Livin and second mitochondrial activator of Caspase(Smac) proteins in non-small cell lung cancer(NSCLC),and analyze their effect on patients'prognosis.Methods:The expressions of Livin and Smac proteins were detected in 89 NSCLC tissue samples and 25 normal lung tissue samples by immunohistochemical technique.Results:The positive expression rates of Livin and Smac proteins in NSCLC tissues were 53.9%,and 58.4% respectively,higher than that in normal lung tissues(P 0.05).The expression level of Smac protein was closely related to lymph node metastasis,TNM stage(P 0.05).Kaplan-Meier analysis revealed a significant impact on survival by Livin protein in NSCLC (P 0.05).Conclusion:Overexpression of Livin protein may play a promoting role in the occurrence and progression of NSCLC.Moreover,it may bring an adverse effect on patients'prognosis.Although overexpression of Smac protein affects the occurrence and progression of NSCLC,it has no relationship with the prognosis. Livin protein may be helpful to evaluate the progression of NSCLC,and to predict the prognosis.
KeywordML-IAP APOPTOSIS INHIBITOR FAMILY GENE SURVIVIN MEMBER TARGET non-small cell lung cancer Livin Smac lymph node metastasis prognosis immunohistochemistry
Indexed ByCSCD
Language英语
CSCD IDCSCD:3299657
Citation statistics
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/150340
Collection中国科学院金属研究所
Affiliation1.中国科学院金属研究所
2.MCH Hosp Tanggu Dist, Ctr Ultrasound, Tianjin 300451, Peoples R China
Recommended Citation
GB/T 7714
Yang Chunlu,Chen Xiao,Zhao Jun,et al. Expressions of Livin and Smac proteins in non-small cell lung cancer[J]. CHINESE JOURNAL OF CANCER RESEARCH,2008,20(2):144-149.
APA Yang Chunlu.,Chen Xiao.,Zhao Jun.,Lan Xingang.,Xu Sun.,...&Zhang Lin.(2008).Expressions of Livin and Smac proteins in non-small cell lung cancer.CHINESE JOURNAL OF CANCER RESEARCH,20(2),144-149.
MLA Yang Chunlu,et al."Expressions of Livin and Smac proteins in non-small cell lung cancer".CHINESE JOURNAL OF CANCER RESEARCH 20.2(2008):144-149.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Yang Chunlu]'s Articles
[Chen Xiao]'s Articles
[Zhao Jun]'s Articles
Baidu academic
Similar articles in Baidu academic
[Yang Chunlu]'s Articles
[Chen Xiao]'s Articles
[Zhao Jun]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Yang Chunlu]'s Articles
[Chen Xiao]'s Articles
[Zhao Jun]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.