Evaluation of entropy for monitoring the depth of anesthesia compared with bispectral index: a multicenter clinical trial

IMR OpenIR

	Evaluation of entropy for monitoring the depth of anesthesia compared with bispectral index: a multicenter clinical trial
其他题名	Evaluation of entropy for monitoring the depth of anesthesia compared with bispectral index: a multicenter clinical trial
	Gao Jiandong 1; Zhao Yujie 1; Xu Chenshi 1; Zhao Jing 2; Huang Yuguang 2; Wang Tianlong 4; Pei Ling 5; Wang Jian 5; Yao Linong 6; Ding Qian 6; Tan Zhiming 7; Zhu Zhirong 8; Yue Yun 1
	2012
发表期刊	CHINESE MEDICAL JOURNAL
ISSN	0366-6999
卷号	125 期号:8 页码:1389-1392
摘要	Background As a new electroencephalogram (EEG) signal processing technique for monitoring the depth of anesthesia, entropy consists of two indices: reaction entropy (RE) and state entropy (SE). Our study compared entropy with classical bispectral index (BIS) in reduction of myoelectrical interference and noxious stimuli with EEG signals.
其他摘要	Background As a new electroencephalogram (EEG) signal processing technique for monitoring the depth of anesthesia, entropy consists of two indices: reaction entropy (RE) and state entropy (SE). Our study compared entropy with classical bispectral index (BIS) in reduction of myoelectrical interference and noxious stimuli with EEG signals. Methods Two hundred and eighty patients (ASA I–II, 18–60 years old) undergoing scheduled surgeries from seven medical centers were enrolled. Anesthesia induction was managed with propofol via the target-controlled infusion (TCI) system. The results of BIS, RE, SE, mean arterial pressure (MAP) and heart rate (HR) were recorded before anesthesia induction, at the moment of unconsciousness, before and 2 minutes after administration of muscle relaxant, and before and one and three minutes after the tracheal intubation. Results The values of half maximum effective concentrations (EC50), 5% effective concentrations (EC05) and 95% effective concentrations (EC95) of propofol effect-site concentration at the onset of unconsciousness were 1.2 (1.1–1.3 μg/ml), 2.5 (2.4–2.5 μg/ml) and 3.7 (3.7–3.8 μg/ml), while those of the predicted plasma propofol concentration were 2.8 (2.7–2.9 μg/ml), 3.9 (3.8–3.9 μg/ml) and 4.9 (4.8–5.0 μg/ml), respectively. The values of BIS, SE and RE were 62, 59 and 63 when 50% of patients lost consciousness, and 79, 80, 85 and 42, 37, 44, respectively, when 5% and 95% of patients were unconscious. The values of BIS, RE and SE dropped two minutes after the injection of muscle relaxant, but there were no significant differences between RE and SE. MAP and HR increased visibly, which indicated a reaction to tracheal intubation; the values of BIS, RE and SE, however, did not display any significant changes. Conclusions This large-sample multicentric study confirmed the values of RE and SE as approximating BIS value, at the onset of unconsciousness during propofol TCI anesthesia. After elimination of myoelectrical activation, all values of RE, SE and BIS decreased significantly and the three indices were less sensitive to noxious stimuli than cardiovascular responses.
关键词	SPECTRAL ENTROPY NEUROMUSCULAR BLOCK MUSCLE-RELAXANT FREQUENCY PANCURONIUM PERFORMANCE SEVOFLURANE HALOTHANE PROPOFOL VALUES propofol target-controlled infusion unconsciousness bispectral index entropy dose-response relationship
收录类别	CSCD
语种	英语
CSCD记录号	CSCD:4498353
引用统计	被引频次：1[CSCD] [CSCD记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/150700
专题	中国科学院金属研究所
作者单位	1.Capital Med University, Beijing Chaoyang Hosp, Dept Anesthesiol, Beijing 100020, Peoples R China 2.Chinese Acad Med Sci, Department Anesthesiol, Beijing 100730, Peoples R China Department Anesthesiol 3.Beijing Union Med Coll Hosp, Beijing 100730, Peoples R China 4.Capital Med University, Xuanwu Hosp, Dept Anesthesiol, Beijing 100053, Peoples R China 5.中国科学院金属研究所 6.中国科学院地球环境研究所 7.复旦大学 8.中国科学院广州地球化学研究所
推荐引用方式 GB/T 7714	Gao Jiandong,Zhao Yujie,Xu Chenshi,et al. Evaluation of entropy for monitoring the depth of anesthesia compared with bispectral index: a multicenter clinical trial[J]. CHINESE MEDICAL JOURNAL,2012,125(8):1389-1392.
APA	Gao Jiandong.,Zhao Yujie.,Xu Chenshi.,Zhao Jing.,Huang Yuguang.,...&Yue Yun.(2012).Evaluation of entropy for monitoring the depth of anesthesia compared with bispectral index: a multicenter clinical trial.CHINESE MEDICAL JOURNAL,125(8),1389-1392.
MLA	Gao Jiandong,et al."Evaluation of entropy for monitoring the depth of anesthesia compared with bispectral index: a multicenter clinical trial".CHINESE MEDICAL JOURNAL 125.8(2012):1389-1392.