Ultra-early treatment of bone marrow-derived mesenchymal stem cells for focal cerebral ischemia/reperfusion injury

IMR OpenIR

	Ultra-early treatment of bone marrow-derived mesenchymal stem cells for focal cerebral ischemia/reperfusion injury
其他题名	Ultra-early treatment of bone marrow-derived mesenchymal stem cells for focal cerebral ischemia/reperfusion injury
	Fan Hongjie; Yu Weidong; Wang Zongli; Wang Qian; He Zhiyi
	2010
发表期刊	NEURAL REGENERATION RESEARCH
ISSN	1673-5374
卷号	5 期号:17 页码:1296-1302
摘要	The time point at which bone marrow-derived mesenchymal stem cells (BMSCs) can be used in transplantation for the treatment of ischemic brain injury remains unclear. In the present study, BMSCs were transplanted to the ischemic site 90 minutes post-ischemia. The results demonstrated that the transplanted BMSCs improved neurological function, reduced infarct volume, increased survivin expression, decreased caspase-3 expression and reduced apoptosis. This suggests that BMSCs transplanted at an ultra-early stage ameliorated brain ischemia by increasing survivin expression, decreasing caspase-3 expression and reducing apoptosis at the ischemia/reperfusion injury site.
其他摘要	The time point at which bone marrow-derived mesenchymal stem cells (BMSCs) can be used in transplantation for the treatment of ischemic brain injury remains unclear. In the present study, BMSCs were transplanted to the ischemic site 90 minutes post-ischemia. The results demonstrated that the transplanted BMSCs improved neurological function, reduced infarct volume, increased survivin expression, decreased caspase-3 expression and reduced apoptosis. This suggests that BMSCs transplanted at an ultra-early stage ameliorated brain ischemia by increasing survivin expression, decreasing caspase-3 expression and reducing apoptosis at the ischemia/reperfusion injury site
关键词	STROMAL CELLS ARTERY OCCLUSION RAT MODEL ISCHEMIA BRAIN TRANSPLANTATION STROKE APOPTOSIS DIFFERENTIATION EXPRESSION bone marrow-derived mesenchymal stem cells cerebral ischemia/reperfusion survivin caspase-3 cell apoptosis brain injury neural regeneration
收录类别	CSCD
语种	英语
资助项目	[Cancer of Larynx, Department of Equipment, First Hospital of China Medical University] ; [Liaoning Provincial Education Department]
CSCD记录号	CSCD:4041464
引用统计	被引频次：2[CSCD] [CSCD记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/151305
专题	中国科学院金属研究所
作者单位	中国科学院金属研究所
推荐引用方式 GB/T 7714	Fan Hongjie,Yu Weidong,Wang Zongli,et al. Ultra-early treatment of bone marrow-derived mesenchymal stem cells for focal cerebral ischemia/reperfusion injury[J]. NEURAL REGENERATION RESEARCH,2010,5(17):1296-1302.
APA	Fan Hongjie,Yu Weidong,Wang Zongli,Wang Qian,&He Zhiyi.(2010).Ultra-early treatment of bone marrow-derived mesenchymal stem cells for focal cerebral ischemia/reperfusion injury.NEURAL REGENERATION RESEARCH,5(17),1296-1302.
MLA	Fan Hongjie,et al."Ultra-early treatment of bone marrow-derived mesenchymal stem cells for focal cerebral ischemia/reperfusion injury".NEURAL REGENERATION RESEARCH 5.17(2010):1296-1302.