| Ultra-early treatment of bone marrow-derived mesenchymal stem cells for focal cerebral ischemia/reperfusion injury | |
| Alternative Title | Ultra-early treatment of bone marrow-derived mesenchymal stem cells for focal cerebral ischemia/reperfusion injury |
| Fan Hongjie; Yu Weidong; Wang Zongli; Wang Qian; He Zhiyi | |
| 2010 | |
| Source Publication | NEURAL REGENERATION RESEARCH
 |
| ISSN | 1673-5374 |
| Volume | 5Issue:17Pages:1296-1302 |
| Abstract | The time point at which bone marrow-derived mesenchymal stem cells (BMSCs) can be used in transplantation for the treatment of ischemic brain injury remains unclear. In the present study, BMSCs were transplanted to the ischemic site 90 minutes post-ischemia. The results demonstrated that the transplanted BMSCs improved neurological function, reduced infarct volume, increased survivin expression, decreased caspase-3 expression and reduced apoptosis. This suggests that BMSCs transplanted at an ultra-early stage ameliorated brain ischemia by increasing survivin expression, decreasing caspase-3 expression and reducing apoptosis at the ischemia/reperfusion injury site. |
| Other Abstract | The time point at which bone marrow-derived mesenchymal stem cells (BMSCs) can be used in transplantation for the treatment of ischemic brain injury remains unclear. In the present study, BMSCs were transplanted to the ischemic site 90 minutes post-ischemia. The results demonstrated that the transplanted BMSCs improved neurological function, reduced infarct volume, increased survivin expression, decreased caspase-3 expression and reduced apoptosis. This suggests that BMSCs transplanted at an ultra-early stage ameliorated brain ischemia by increasing survivin expression, decreasing caspase-3 expression and reducing apoptosis at the ischemia/reperfusion injury site |
| Keyword | STROMAL CELLS ARTERY OCCLUSION RAT MODEL ISCHEMIA BRAIN TRANSPLANTATION STROKE APOPTOSIS DIFFERENTIATION EXPRESSION bone marrow-derived mesenchymal stem cells cerebral ischemia/reperfusion survivin caspase-3 cell apoptosis brain injury neural regeneration |
| Indexed By | CSCD |
| Language | 英语 |
| Funding Project | [Cancer of Larynx, Department of Equipment, First Hospital of China Medical University] ; [Liaoning Provincial Education Department] |
| CSCD ID | CSCD:4041464 |
| Citation statistics |
Cited Times:2[CSCD]
[CSCD Record]
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| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/151308 |
| Collection | 中国科学院金属研究所 |
| Affiliation | 中国科学院金属研究所 |
| Recommended Citation GB/T 7714 | Fan Hongjie,Yu Weidong,Wang Zongli,et al. Ultra-early treatment of bone marrow-derived mesenchymal stem cells for focal cerebral ischemia/reperfusion injury[J]. NEURAL REGENERATION RESEARCH,2010,5(17):1296-1302. |
| APA | Fan Hongjie,Yu Weidong,Wang Zongli,Wang Qian,&He Zhiyi.(2010).Ultra-early treatment of bone marrow-derived mesenchymal stem cells for focal cerebral ischemia/reperfusion injury.NEURAL REGENERATION RESEARCH,5(17),1296-1302. |
| MLA | Fan Hongjie,et al."Ultra-early treatment of bone marrow-derived mesenchymal stem cells for focal cerebral ischemia/reperfusion injury".NEURAL REGENERATION RESEARCH 5.17(2010):1296-1302. |
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