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Ultra-early treatment of bone marrow-derived mesenchymal stem cells for focal cerebral ischemia/reperfusion injury
Alternative TitleUltra-early treatment of bone marrow-derived mesenchymal stem cells for focal cerebral ischemia/reperfusion injury
Fan Hongjie; Yu Weidong; Wang Zongli; Wang Qian; He Zhiyi
2010
Source PublicationNEURAL REGENERATION RESEARCH
ISSN1673-5374
Volume5Issue:17Pages:1296-1302
AbstractThe time point at which bone marrow-derived mesenchymal stem cells (BMSCs) can be used in transplantation for the treatment of ischemic brain injury remains unclear. In the present study, BMSCs were transplanted to the ischemic site 90 minutes post-ischemia. The results demonstrated that the transplanted BMSCs improved neurological function, reduced infarct volume, increased survivin expression, decreased caspase-3 expression and reduced apoptosis. This suggests that BMSCs transplanted at an ultra-early stage ameliorated brain ischemia by increasing survivin expression, decreasing caspase-3 expression and reducing apoptosis at the ischemia/reperfusion injury site.
Other AbstractThe time point at which bone marrow-derived mesenchymal stem cells (BMSCs) can be used in transplantation for the treatment of ischemic brain injury remains unclear. In the present study, BMSCs were transplanted to the ischemic site 90 minutes post-ischemia. The results demonstrated that the transplanted BMSCs improved neurological function, reduced infarct volume, increased survivin expression, decreased caspase-3 expression and reduced apoptosis. This suggests that BMSCs transplanted at an ultra-early stage ameliorated brain ischemia by increasing survivin expression, decreasing caspase-3 expression and reducing apoptosis at the ischemia/reperfusion injury site
KeywordSTROMAL CELLS ARTERY OCCLUSION RAT MODEL ISCHEMIA BRAIN TRANSPLANTATION STROKE APOPTOSIS DIFFERENTIATION EXPRESSION bone marrow-derived mesenchymal stem cells cerebral ischemia/reperfusion survivin caspase-3 cell apoptosis brain injury neural regeneration
Indexed ByCSCD
Language英语
Funding Project[Cancer of Larynx, Department of Equipment, First Hospital of China Medical University] ; [Liaoning Provincial Education Department]
CSCD IDCSCD:4041464
Citation statistics
Cited Times:2[CSCD]   [CSCD Record]
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/151308
Collection中国科学院金属研究所
Affiliation中国科学院金属研究所
Recommended Citation
GB/T 7714
Fan Hongjie,Yu Weidong,Wang Zongli,et al. Ultra-early treatment of bone marrow-derived mesenchymal stem cells for focal cerebral ischemia/reperfusion injury[J]. NEURAL REGENERATION RESEARCH,2010,5(17):1296-1302.
APA Fan Hongjie,Yu Weidong,Wang Zongli,Wang Qian,&He Zhiyi.(2010).Ultra-early treatment of bone marrow-derived mesenchymal stem cells for focal cerebral ischemia/reperfusion injury.NEURAL REGENERATION RESEARCH,5(17),1296-1302.
MLA Fan Hongjie,et al."Ultra-early treatment of bone marrow-derived mesenchymal stem cells for focal cerebral ischemia/reperfusion injury".NEURAL REGENERATION RESEARCH 5.17(2010):1296-1302.
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