| Characterization of a novel toxin-antitoxin module, VapBC, encoded by Leptospira interrogans chromosome | |
| Alternative Title | Characterization of a novel toxin-antitoxin module, VapBC, encoded by Leptospira interrogans chromosome |
| Zhang YX1; Guo XK1; Wu C1; Bi B1; Ren SX1; Wu CF1; Zhao GP1 | |
| 2004 | |
| Source Publication | CELL RESEARCH
 |
| ISSN | 1001-0602 |
| Volume | 14Issue:3Pages:208-216 |
| Abstract | Comparative genomic analysis of the coding sequences (CDSs) of Leptospira interrogans revealed a pair of closely linked genes homologous to the vapBC loci of many other bacteria with respect to both deduced amino acid sequences and operon organizations. Expression of single vapC gene in Escherichia coli resulted in inhibition of bacterial growth, whereas co-expression of vapBC restored the growth effectively. This phenotype is typical for three other characterized toxin-antitoxin systems of bacteria, i.e., mazEFl |
| Other Abstract | Comparative genomic analysis of the coding sequences (CDSs) of Leptospira interrogans revealed a pair of closely linked genes homologous to the vapBC loci of many other bacteria with respect to both deduced amino acid sequences and operon organizations. Expression of single vapC gene in Escherichia coli resulted in inhibition of bacterial growth,whereas co-expression of vapBC restored the growth effectively. This phenotype is typical for three other characterized toxin-antitoxin systems of bacteria, i.e., mazEF1 |
| Keyword | STABILITY SYSTEM PLASMID R1 CELL-DEATH PARD GENE REPLICATION COMPLEX IDENTIFICATION RECOMBINATION MAINTENANCE Leptospria toxin-antitoxin system VapBC co-evolution speciation |
| Indexed By | CSCD |
| Language | 英语 |
| CSCD ID | CSCD:1843650 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/151412 |
| Collection | 中国科学院金属研究所 |
| Affiliation | 1.中国科学院 2.中国科学院金属研究所 3.Shanghai Med University 2 4.中国科学院青岛生物能源与过程研究所 |
| Recommended Citation GB/T 7714 | Zhang YX,Guo XK,Wu C,et al. Characterization of a novel toxin-antitoxin module, VapBC, encoded by Leptospira interrogans chromosome[J]. CELL RESEARCH,2004,14(3):208-216. |
| APA | Zhang YX.,Guo XK.,Wu C.,Bi B.,Ren SX.,...&Zhao GP.(2004).Characterization of a novel toxin-antitoxin module, VapBC, encoded by Leptospira interrogans chromosome.CELL RESEARCH,14(3),208-216. |
| MLA | Zhang YX,et al."Characterization of a novel toxin-antitoxin module, VapBC, encoded by Leptospira interrogans chromosome".CELL RESEARCH 14.3(2004):208-216. |
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