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Characterization of a novel toxin-antitoxin module, VapBC, encoded by Leptospira interrogans chromosome
Alternative TitleCharacterization of a novel toxin-antitoxin module, VapBC, encoded by Leptospira interrogans chromosome
Zhang YX1; Guo XK1; Wu C1; Bi B1; Ren SX1; Wu CF1; Zhao GP1
2004
Source PublicationCELL RESEARCH
ISSN1001-0602
Volume14Issue:3Pages:208-216
AbstractComparative genomic analysis of the coding sequences (CDSs) of Leptospira interrogans revealed a pair of closely linked genes homologous to the vapBC loci of many other bacteria with respect to both deduced amino acid sequences and operon organizations. Expression of single vapC gene in Escherichia coli resulted in inhibition of bacterial growth, whereas co-expression of vapBC restored the growth effectively. This phenotype is typical for three other characterized toxin-antitoxin systems of bacteria, i.e., mazEFl
Other AbstractComparative genomic analysis of the coding sequences (CDSs) of Leptospira interrogans revealed a pair of closely linked genes homologous to the vapBC loci of many other bacteria with respect to both deduced amino acid sequences and operon organizations. Expression of single vapC gene in Escherichia coli resulted in inhibition of bacterial growth,whereas co-expression of vapBC restored the growth effectively. This phenotype is typical for three other characterized toxin-antitoxin systems of bacteria, i.e., mazEF1
KeywordSTABILITY SYSTEM PLASMID R1 CELL-DEATH PARD GENE REPLICATION COMPLEX IDENTIFICATION RECOMBINATION MAINTENANCE Leptospria toxin-antitoxin system VapBC co-evolution speciation
Indexed ByCSCD
Language英语
CSCD IDCSCD:1843650
Citation statistics
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/151412
Collection中国科学院金属研究所
Affiliation1.中国科学院
2.中国科学院金属研究所
3.Shanghai Med University 2
4.中国科学院青岛生物能源与过程研究所
Recommended Citation
GB/T 7714
Zhang YX,Guo XK,Wu C,et al. Characterization of a novel toxin-antitoxin module, VapBC, encoded by Leptospira interrogans chromosome[J]. CELL RESEARCH,2004,14(3):208-216.
APA Zhang YX.,Guo XK.,Wu C.,Bi B.,Ren SX.,...&Zhao GP.(2004).Characterization of a novel toxin-antitoxin module, VapBC, encoded by Leptospira interrogans chromosome.CELL RESEARCH,14(3),208-216.
MLA Zhang YX,et al."Characterization of a novel toxin-antitoxin module, VapBC, encoded by Leptospira interrogans chromosome".CELL RESEARCH 14.3(2004):208-216.
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