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Danshen (Radix Salviae Miltiorrhizae) reverses renal injury induced by myocardial infarction
Alternative TitleDanshen (Radix Salviae Miltiorrhizae) reverses renal injury induced by myocardial infarction
Lu Xiaomei; Jin Yunan; Ma Ling; Du Lili
2015
Source PublicationJOURNAL OF TRADITIONAL CHINESE MEDICINE
ISSN0255-2922
Volume35Issue:3Pages:306-311
AbstractOBJECTIVE: To evaluate the protection of Danshen (Radix Salviae Miltiorrhizae) (SM) injection in myocardial infarction (MI) induced renal damage.
Other AbstractOBJECTIVE: To evaluate the protection of Danshen (Radix Solvioe Miltiorrhizae) (SM) injection in myocardial infarction (Ml) induced renal damage. METHODS: Forty male C57 mice were divided into control group, Ml group and SM group. In Ml group, the left coronary artery was occluded for 8 weeks; the same procedure was used for the SM group, with the additional step of SM (0.2 mL) administered intraperitoneally for 56 days. Before surgery and 8 weeks later, transthoracic echocardiography was performed and urine protein and albumin was measured. At the end of the time, all mice were killed and kidneys removed for reactive oxygen species (ROS) and fibrosis analysis, plasma was collected for blood urea nitrogen and serum creatinine determination. RESULTS: Ml slightly decreased renal function and increased production of ROS, accompanied with renal fibrosis. Administration of SM reduced production of ROS and increased renal function, it also re duced renal fibrosis. CONCLUSION: Ml plays a causal role in renal injury and SM exerts renal-protective effects, probably by its antioxidant activities.
KeywordHEART-FAILURE ISCHEMIA KIDNEY INJECTION MEDICINE DISEASE RATS Salvia Miltiorrhiza Myocardial infarction Reactive oxygen species
Indexed ByCSCD
Language英语
Funding Project[National Natural Science Foundation of China]
CSCD IDCSCD:5449519
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Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/151594
Collection中国科学院金属研究所
Affiliation中国科学院金属研究所
Recommended Citation
GB/T 7714
Lu Xiaomei,Jin Yunan,Ma Ling,et al. Danshen (Radix Salviae Miltiorrhizae) reverses renal injury induced by myocardial infarction[J]. JOURNAL OF TRADITIONAL CHINESE MEDICINE,2015,35(3):306-311.
APA Lu Xiaomei,Jin Yunan,Ma Ling,&Du Lili.(2015).Danshen (Radix Salviae Miltiorrhizae) reverses renal injury induced by myocardial infarction.JOURNAL OF TRADITIONAL CHINESE MEDICINE,35(3),306-311.
MLA Lu Xiaomei,et al."Danshen (Radix Salviae Miltiorrhizae) reverses renal injury induced by myocardial infarction".JOURNAL OF TRADITIONAL CHINESE MEDICINE 35.3(2015):306-311.
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