Danshen (Radix Salviae Miltiorrhizae) reverses renal injury induced by myocardial infarction

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	Danshen (Radix Salviae Miltiorrhizae) reverses renal injury induced by myocardial infarction
其他题名	Danshen (Radix Salviae Miltiorrhizae) reverses renal injury induced by myocardial infarction
	Lu Xiaomei; Jin Yunan; Ma Ling; Du Lili
	2015
发表期刊	JOURNAL OF TRADITIONAL CHINESE MEDICINE
ISSN	0255-2922
卷号	35 期号:3 页码:306-311
摘要	OBJECTIVE: To evaluate the protection of Danshen (Radix Salviae Miltiorrhizae) (SM) injection in myocardial infarction (MI) induced renal damage.
其他摘要	OBJECTIVE: To evaluate the protection of Danshen (Radix Solvioe Miltiorrhizae) (SM) injection in myocardial infarction (Ml) induced renal damage. METHODS: Forty male C57 mice were divided into control group, Ml group and SM group. In Ml group, the left coronary artery was occluded for 8 weeks; the same procedure was used for the SM group, with the additional step of SM (0.2 mL) administered intraperitoneally for 56 days. Before surgery and 8 weeks later, transthoracic echocardiography was performed and urine protein and albumin was measured. At the end of the time, all mice were killed and kidneys removed for reactive oxygen species (ROS) and fibrosis analysis, plasma was collected for blood urea nitrogen and serum creatinine determination. RESULTS: Ml slightly decreased renal function and increased production of ROS, accompanied with renal fibrosis. Administration of SM reduced production of ROS and increased renal function, it also re duced renal fibrosis. CONCLUSION: Ml plays a causal role in renal injury and SM exerts renal-protective effects, probably by its antioxidant activities.
关键词	HEART-FAILURE ISCHEMIA KIDNEY INJECTION MEDICINE DISEASE RATS Salvia Miltiorrhiza Myocardial infarction Reactive oxygen species
收录类别	CSCD
语种	英语
资助项目	[National Natural Science Foundation of China]
CSCD记录号	CSCD:5449519
引用统计	被引频次：1[CSCD] [CSCD记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/151594
专题	中国科学院金属研究所
作者单位	中国科学院金属研究所
推荐引用方式 GB/T 7714	Lu Xiaomei,Jin Yunan,Ma Ling,et al. Danshen (Radix Salviae Miltiorrhizae) reverses renal injury induced by myocardial infarction[J]. JOURNAL OF TRADITIONAL CHINESE MEDICINE,2015,35(3):306-311.
APA	Lu Xiaomei,Jin Yunan,Ma Ling,&Du Lili.(2015).Danshen (Radix Salviae Miltiorrhizae) reverses renal injury induced by myocardial infarction.JOURNAL OF TRADITIONAL CHINESE MEDICINE,35(3),306-311.
MLA	Lu Xiaomei,et al."Danshen (Radix Salviae Miltiorrhizae) reverses renal injury induced by myocardial infarction".JOURNAL OF TRADITIONAL CHINESE MEDICINE 35.3(2015):306-311.