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Synthesis and in vitro anti-hepatitis B virus activity of 1H-benzimidazol-5-ol derivatives
Alternative TitleSynthesis and in vitro anti-hepatitis B virus activity of 1 H-benzimidazol-5-ol derivatives
Chen Dong; Zhai Xin; Yuan Qiu Hui; Luo Jian; Xie Si Chang; Gong Ping
2010
Source PublicationCHINESE CHEMICAL LETTERS
ISSN1001-8417
Volume21Issue:11Pages:1326-1329
AbstractA series of 1H-benzimidazol-5-ol derivatives were synthesized and evaluated for their anti-hepatitis B virus (HBV) activity and cytotoxicity in HepG2.2.15 cells. Half of the tested compounds were found to be potent against HBsAg secretion with IC50 values less than 100 mu mol/L. Compounds 14c, 14d, and 14e showed significant inhibitory activity to the viral antigen HBeAg. (C) 2010 Ping Gong. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
Other AbstractA series of 1H-benzimidazol-5-ol derivatives were synthesized and evaluated for their anti-hepatitis B virus (HBV) activity and cytotoxicity in HepG2.2.15 cells. Half of the tested compounds were found to be potent against HBsAg secretion with IC_(50) values less than 100 μmol/L. Compounds 14c, 14d, and 14e showed significant inhibitory activity to the viral antigen HBeAg
Keyword1H-benzimidazol-5-ol Synthesis Anti-HBV activity
Indexed ByCSCD
Language英语
CSCD IDCSCD:4076121
Citation statistics
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/151671
Collection中国科学院金属研究所
Affiliation中国科学院金属研究所
Recommended Citation
GB/T 7714
Chen Dong,Zhai Xin,Yuan Qiu Hui,et al. Synthesis and in vitro anti-hepatitis B virus activity of 1H-benzimidazol-5-ol derivatives[J]. CHINESE CHEMICAL LETTERS,2010,21(11):1326-1329.
APA Chen Dong,Zhai Xin,Yuan Qiu Hui,Luo Jian,Xie Si Chang,&Gong Ping.(2010).Synthesis and in vitro anti-hepatitis B virus activity of 1H-benzimidazol-5-ol derivatives.CHINESE CHEMICAL LETTERS,21(11),1326-1329.
MLA Chen Dong,et al."Synthesis and in vitro anti-hepatitis B virus activity of 1H-benzimidazol-5-ol derivatives".CHINESE CHEMICAL LETTERS 21.11(2010):1326-1329.
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