| Sleeve gastrectomy prevents lipoprotein receptor-1 expression in aortas of obese rats | |
| Alternative Title | Sleeve gastrectomy prevents lipoprotein receptor-1expression in aortas of obese rats |
| Bai Jie; Wang Yong; Liu Yuan; Geng DongHua; Liu JinGang | |
| 2011 | |
| Source Publication | WORLD JOURNAL OF GASTROENTEROLOGY
 |
| ISSN | 1007-9327 |
| Volume | 17Issue:32Pages:3739-3744 |
| Abstract | AIM: To investigate the effects of sleeve gastrectomy on adipose tissue infiltration and lectin-like oxidized low density lipoprotein receptor-1 (LOX-1) expression in rat aortas. |
| Other Abstract | AIM:To investigate the effects of sleeve gastrectomy on adipose tissue infiltration and lectin-like oxidized low density lipoprotein receptor-1(LOX-1)expression in rat aortas. METHODS:Twenty-four rats were randomized into three groups:normal chow(control),high fat diet(HD) and high fat diet with sleeve gastrectomy(SG).After surgery,the HD and SG groups were fed a high fat diet.Animals were sacrificed and plasma high density lipoprotein(HDL)and low density lipoprotein(LDL)levels were determined.LOX-1 protein and LOX-1 mRNA expression was also measured.Aortas were stained with Nile red to visualize adipose tissue. RESULT:Body weights were higher in the HD group compared to the other groups.HDL levels in control, HD,and SG groups were 32.9±6.2 mg/dL,43.4±4.0 mg/dL and 37.5±4.3 mg/dL,respectively.LDL levels in control,HD,and SG groups were 31.8±4.5 mg/dL, 53.3±5.1 mg/dL and 40.5±3.7 mg/dL,respectively. LOX-1 protein and LOX-1 mRNA expression was greater in the HD group versus the other groups.Staining for adipose tissue in aortas was greater in the HD group in comparison to the other groups.Thus,a high fat diet elevates LOX-1 protein and mRNA expression in aorta. CONCLUSION:Sleeve gastrectomy decreases plasma LDL levels,and downregulates LOX-1 protein and mRNA expression. |
| Keyword | LOW-DENSITY-LIPOPROTEIN OXIDIZED LDL RECEPTOR-1 VASCULAR ENDOTHELIAL-CELLS WEIGHT-LOSS BLOOD-PRESSURE GASTRIC BYPASS LONG-TERM HYPERTENSION LOX-1 WOMEN Sleeve gastrectomy Morbid obesity High fat diet Aorta Lipoprotein receptor-1 expression |
| Indexed By | CSCD |
| Language | 英语 |
| Funding Project | [National Natural Science Foundation of China] ; [Special Fund for Technology of Liaoning Province] |
| CSCD ID | CSCD:4334543 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/151704 |
| Collection | 中国科学院金属研究所 |
| Affiliation | 中国科学院金属研究所 |
| Recommended Citation GB/T 7714 | Bai Jie,Wang Yong,Liu Yuan,et al. Sleeve gastrectomy prevents lipoprotein receptor-1 expression in aortas of obese rats[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2011,17(32):3739-3744. |
| APA | Bai Jie,Wang Yong,Liu Yuan,Geng DongHua,&Liu JinGang.(2011).Sleeve gastrectomy prevents lipoprotein receptor-1 expression in aortas of obese rats.WORLD JOURNAL OF GASTROENTEROLOGY,17(32),3739-3744. |
| MLA | Bai Jie,et al."Sleeve gastrectomy prevents lipoprotein receptor-1 expression in aortas of obese rats".WORLD JOURNAL OF GASTROENTEROLOGY 17.32(2011):3739-3744. |
| Files in This Item: | There are no files associated with this item. | |||||
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment