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Cyclooxygenase 2 polymorphism and colorectal cancer: -765G > C variant modifies risk associated with smoking and body mass index
Alternative TitleCyclooxygenase 2 polymorphism and colorectal cancer: -765G>C variant modifies risk associated with smoking and body mass index
Xing LiLi; Wang ZhenNing; Jiang Li; Zhang Yong; Xu YingYing; Li Juan; Luo Yang; Zhang Xue
2008
Source PublicationWORLD JOURNAL OF GASTROENTEROLOGY
ISSN1007-9327
Volume14Issue:11Pages:1785-1789
AbstractAIM: To explore whether cyclooxygenase 2 (COX-2) -765G > C polymorphism is associated with susceptibility of colorectal cancer (CRC) and to evaluate the risk of colorectal cancer in relation to environmental exposures and polymorphism.
Other AbstractAIM: To explore whether cyclooxygenase 2 (COX-2) -765G>C polymorphism is associated with susceptibility of colorectal cancer (CRC) and to evaluate the risk of colorectal cancer in relation to environmental exposures and polymorphism.METHODS: We conducted a case-control study of 137 patients with colorectal cancer and 199 cancer-free controls in northeast China. Multivariate logistic regression analysis was performed to calculate the adjusted odds ratio (OR) and 95% confidence interval (95% CI).RESULTS: The -765G>C polymorphism was not independently associated with CRC risk. However, risk associated with the polymorphism differed by smoking and body mass index (BMI). Smoking and BMI associated risks were stronger among those with -765GG genotype, showing that smokers had a 2.682-fold greater risk of CRC than nonsmokers (51/43 vs 68/126, P = 0.006). Compared to those with a normal body mass index (BMI 18.5-22.9), those with overweight (BMI 23-24.9) had a 3.909-fold higher risk of CRC (OR = 3.909, 95% CI = 2.081-7.344; P < 0.001), while those with obesity (BMI > 25) had a 2.031- fold higher risk of CRC (OR = 1.107, 95% CI = 1.107-3.726; P = 0.022).CONCLUSION: Although COX-2 -765G>C polymorphism is not associated with an increased risk of CRC, -765GG genotype appears to be related to an increased risk in the presence of smoking and higher BMI.
KeywordINFLAMMATORY-BOWEL-DISEASE SINGAPORE CHINESE HEALTH GENE INHIBITION GROWTH CELLS WOMEN colorectal cancer cyclooxygenase 2 polymorphism smoking body mass index
Indexed ByCSCD
Language英语
CSCD IDCSCD:3317335
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Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/151778
Collection中国科学院金属研究所
Affiliation中国科学院金属研究所
Recommended Citation
GB/T 7714
Xing LiLi,Wang ZhenNing,Jiang Li,et al. Cyclooxygenase 2 polymorphism and colorectal cancer: -765G > C variant modifies risk associated with smoking and body mass index[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2008,14(11):1785-1789.
APA Xing LiLi.,Wang ZhenNing.,Jiang Li.,Zhang Yong.,Xu YingYing.,...&Zhang Xue.(2008).Cyclooxygenase 2 polymorphism and colorectal cancer: -765G > C variant modifies risk associated with smoking and body mass index.WORLD JOURNAL OF GASTROENTEROLOGY,14(11),1785-1789.
MLA Xing LiLi,et al."Cyclooxygenase 2 polymorphism and colorectal cancer: -765G > C variant modifies risk associated with smoking and body mass index".WORLD JOURNAL OF GASTROENTEROLOGY 14.11(2008):1785-1789.
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