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Umbilical cord mesenchymal stem cell transplantation for the treatment of Duchenne muscular dystrophy
Alternative TitleUmbilical cord mesenchymal stem cell transplantation for the treatment of Duchenne muscular dystrophy
Yang Xiaofeng; Xu Yifeng; Lue Naiwu; Zhang Yibin; Wang Hongmei; Lue Xin; Cui Jiping; Zhou Jinxu; Shan Hong; Wu Yanxiang; Liu Xinping
2011
Source PublicationNEURAL REGENERATION RESEARCH
ISSN1673-5374
Volume6Issue:10Pages:785-789
AbstractDue to their relative abundance, stable biological properties and excellent reproductive activity, umbilical cord mesenchymal stem cells have previously been utilized for the treatment of Duchenne muscular dystrophy, which is a muscular atrophy disease. Three patients who were clinically and pathologically diagnosed with Duchenne muscular dystrophy were transplanted with umbilical cord mesenchymal stem cells by intravenous infusion, in combination with multi-point intramuscular injection. They were followed up for 12 months after cell transplantation. Results showed that clinical symptoms significantly improved, daily living activity and muscle strength were enhanced, the sero-enzyme, electromyogram, and MRI scans showed improvement, and dystrophin was expressed in the muscle cell membrane. Hematoxylin-eosin staining of a muscle biopsy revealed that muscle fibers were well arranged, fibrous degeneration was alleviated, and fat infiltration was improved. These pieces of evidence suggest that umbilical cord mesenchymal stem cell transplantation can be considered as a new regimen for Duchenne muscular dystrophy.
Other AbstractDue to their relative abundance,stable biological properties and excellent reproductive activity,umbilical cord mesenchymal stem cells have previously been utilized for the treatment of Duchenne muscular dystrophy,which is a muscular atrophy disease.Three patients who were clinically and pathologically diagnosed with Duchenne muscular dystrophy were transplanted with umbilical cord mesenchymal stem cells by intravenous infusion,in combination with multi-point intramuscular injection.They were followed up for 12 months after cell transplantation.Results showed that clinical symptoms significantly improved,daily living activity and muscle strength were enhanced,the sero-enzyme,electromyogram,and MRI scans showed improvement,and dystrophin was expressed in the muscle cell membrane.Hematoxylin-eosin staining of a muscle biopsy revealed that muscle fibers were well arranged,fibrous degeneration was alleviated,and fat infiltration was improved.These pieces of evidence suggest that umbilical cord mesenchymal stem cell transplantation can be considered as a new regimen for Duchenne muscular dystrophy.
KeywordIN-VITRO ENDOTHELIAL-CELLS PROGENITOR CELLS CULTURE VIVO umbilical cord mesenchymal stem cells Duchenne muscular dystrophy case report dystrophin muscular force activities of daily living
Indexed ByCSCD
Language英语
Funding Project[Key Projects of Liaoning Province]
CSCD IDCSCD:4258073
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Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/151818
Collection中国科学院金属研究所
Affiliation中国科学院金属研究所
Recommended Citation
GB/T 7714
Yang Xiaofeng,Xu Yifeng,Lue Naiwu,et al. Umbilical cord mesenchymal stem cell transplantation for the treatment of Duchenne muscular dystrophy[J]. NEURAL REGENERATION RESEARCH,2011,6(10):785-789.
APA Yang Xiaofeng.,Xu Yifeng.,Lue Naiwu.,Zhang Yibin.,Wang Hongmei.,...&Liu Xinping.(2011).Umbilical cord mesenchymal stem cell transplantation for the treatment of Duchenne muscular dystrophy.NEURAL REGENERATION RESEARCH,6(10),785-789.
MLA Yang Xiaofeng,et al."Umbilical cord mesenchymal stem cell transplantation for the treatment of Duchenne muscular dystrophy".NEURAL REGENERATION RESEARCH 6.10(2011):785-789.
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