| Umbilical cord mesenchymal stem cell transplantation for the treatment of Duchenne muscular dystrophy | |
| Alternative Title | Umbilical cord mesenchymal stem cell transplantation for the treatment of Duchenne muscular dystrophy |
| Yang Xiaofeng; Xu Yifeng; Lue Naiwu; Zhang Yibin; Wang Hongmei; Lue Xin; Cui Jiping; Zhou Jinxu; Shan Hong; Wu Yanxiang; Liu Xinping | |
| 2011 | |
| Source Publication | NEURAL REGENERATION RESEARCH
 |
| ISSN | 1673-5374 |
| Volume | 6Issue:10Pages:785-789 |
| Abstract | Due to their relative abundance, stable biological properties and excellent reproductive activity, umbilical cord mesenchymal stem cells have previously been utilized for the treatment of Duchenne muscular dystrophy, which is a muscular atrophy disease. Three patients who were clinically and pathologically diagnosed with Duchenne muscular dystrophy were transplanted with umbilical cord mesenchymal stem cells by intravenous infusion, in combination with multi-point intramuscular injection. They were followed up for 12 months after cell transplantation. Results showed that clinical symptoms significantly improved, daily living activity and muscle strength were enhanced, the sero-enzyme, electromyogram, and MRI scans showed improvement, and dystrophin was expressed in the muscle cell membrane. Hematoxylin-eosin staining of a muscle biopsy revealed that muscle fibers were well arranged, fibrous degeneration was alleviated, and fat infiltration was improved. These pieces of evidence suggest that umbilical cord mesenchymal stem cell transplantation can be considered as a new regimen for Duchenne muscular dystrophy. |
| Other Abstract | Due to their relative abundance,stable biological properties and excellent reproductive activity,umbilical cord mesenchymal stem cells have previously been utilized for the treatment of Duchenne muscular dystrophy,which is a muscular atrophy disease.Three patients who were clinically and pathologically diagnosed with Duchenne muscular dystrophy were transplanted with umbilical cord mesenchymal stem cells by intravenous infusion,in combination with multi-point intramuscular injection.They were followed up for 12 months after cell transplantation.Results showed that clinical symptoms significantly improved,daily living activity and muscle strength were enhanced,the sero-enzyme,electromyogram,and MRI scans showed improvement,and dystrophin was expressed in the muscle cell membrane.Hematoxylin-eosin staining of a muscle biopsy revealed that muscle fibers were well arranged,fibrous degeneration was alleviated,and fat infiltration was improved.These pieces of evidence suggest that umbilical cord mesenchymal stem cell transplantation can be considered as a new regimen for Duchenne muscular dystrophy. |
| Keyword | IN-VITRO ENDOTHELIAL-CELLS PROGENITOR CELLS CULTURE VIVO umbilical cord mesenchymal stem cells Duchenne muscular dystrophy case report dystrophin muscular force activities of daily living |
| Indexed By | CSCD |
| Language | 英语 |
| Funding Project | [Key Projects of Liaoning Province] |
| CSCD ID | CSCD:4258073 |
| Citation statistics |
Cited Times:4[CSCD]
[CSCD Record]
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| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/151818 |
| Collection | 中国科学院金属研究所 |
| Affiliation | 中国科学院金属研究所 |
| Recommended Citation GB/T 7714 | Yang Xiaofeng,Xu Yifeng,Lue Naiwu,et al. Umbilical cord mesenchymal stem cell transplantation for the treatment of Duchenne muscular dystrophy[J]. NEURAL REGENERATION RESEARCH,2011,6(10):785-789. |
| APA | Yang Xiaofeng.,Xu Yifeng.,Lue Naiwu.,Zhang Yibin.,Wang Hongmei.,...&Liu Xinping.(2011).Umbilical cord mesenchymal stem cell transplantation for the treatment of Duchenne muscular dystrophy.NEURAL REGENERATION RESEARCH,6(10),785-789. |
| MLA | Yang Xiaofeng,et al."Umbilical cord mesenchymal stem cell transplantation for the treatment of Duchenne muscular dystrophy".NEURAL REGENERATION RESEARCH 6.10(2011):785-789. |
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